Objective To investigate the genetic features of fulminant type 1 diabetes mellitus in the northern populations of *** Analyzed the clinical features of two cases of fulmi nant type 1 diabetes from the Second hospital...
Objective To investigate the genetic features of fulminant type 1 diabetes mellitus in the northern populations of *** Analyzed the clinical features of two cases of fulmi nant type 1 diabetes from the Second hospital of Dalian Medical University underwent gene polymorphism *** 'di rect sequencingr'method to locate and observe following polymorphism:rs1800610 in TNF gene.
Diabetic foot ulcers (DFU) take a long time to heal,seriously affect the quality of life of patients and has a heavy burden on social *** 1998,a multicenter epidemiological study on inpatients with chronic wounds indi...
Diabetic foot ulcers (DFU) take a long time to heal,seriously affect the quality of life of patients and has a heavy burden on social *** 1998,a multicenter epidemiological study on inpatients with chronic wounds indicated that the leading causes of chron ic cutaneous wounds were trauma (67％),with low frequency of DFU (＜5％).Ten years later,the leading causes of chronic cutaneous wounds were DFU (32.6％),trauma/burns (23.8％),iatrogenic factors (10.6％) and pressure ulcer (10.5％).DFU is the leading cause of amputation in patients with diabetes,also big burden for patients' family and society.
Objectives To determine whether intracerebroventricular injec tion of GalR1 agonist M617 would elevate GLUT4 expression in the cardiac muscle of type 2 diabetic *** The rats tested were divided into four groups:rats f...
Objectives To determine whether intracerebroventricular injec tion of GalR1 agonist M617 would elevate GLUT4 expression in the cardiac muscle of type 2 diabetic *** The rats tested were divided into four groups:rats from healthy and type 2 diabetic drug groupswere injected with 10 nM/kg/d M617 in5 μ *** muscle was processed for determi nation of GLUT4 mRNA expression and GLUT4 protein levels.
随着新一代测序技术的建立,人类对肿瘤的治疗进入一个新的时代。2015年年初美国总统奥巴马在今年的国情咨文中启动了"精准医学计划",在随后的讲话中他进一步阐述了精准医学计划的内容。早在2012年新英格兰杂志曾发表一篇文章标题为"Preparing for Precision Medicine",文中对精准医学进行了定义,即用最先进的分子特征谱,结合临床病理资料量体裁衣,设计针对每个病人的诊断、预后、治疗方案。精准医学主要由两项重要技术驱动—DNA测序和基因组技术。力争把根据基因匹配肿瘤用药变得像输血配血型那样标准化,把找出正确的用药剂量变得像测体温那样简单。而实现精准医学必须具备5个要素:1,完善的生物信息学分析,包括临床病理资料和基因组数据等;2,先进的检测技术及方法学;3,疾病特异性分子标记物的发现及功能研究;4,高特异性靶向药物的开发;5,政策和法规的支持。我国的医疗水平与美国比较尚存在一定的差距,实现精准医学的道路更加漫长。但是国内学者及医疗机构已经开始关注并进行了有益尝试。复旦大学附属中山医院成立了精准医学中心,从心脏疾病,糖尿病和恶性肿瘤的个体化治疗和预防以及基因体检等方面,进行了精准医学的探索和实践,取得一些进展并积累了经验,为进一步推广及实现精准医学打下了基础。
Animal models have contributed enormously to study in the field of type 1 diabetes(T1D).Discovered in the late 1970s,NOD mouse has become necessary in the study of T1D and provided researchers important tools to condu...
Animal models have contributed enormously to study in the field of type 1 diabetes(T1D).Discovered in the late 1970s,NOD mouse has become necessary in the study of T1D and provided researchers important tools to conduct studies that could not otherwise be performed in ***'s genome predisposes this strain of female mice to spontaneously developing T1D,sharing several crucial features with the human T1D,such as the disease is characterized by the specific destruction of insulin producing β cells,is primarily mediated by T lymphocytes,and is under complex polygenic *** mice are closely related to T1D-prone NOD mice.
In eukaryotic cells,accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) lumen triggers ER stress,activating the cellular unfolded protein response (UPR).IRE1 (inositol-requiring enzyme 1),an ...
In eukaryotic cells,accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) lumen triggers ER stress,activating the cellular unfolded protein response (UPR).IRE1 (inositol-requiring enzyme 1),an ER-localized transmembrane signal transducer,is ancient ER stress sensor that is conserved from yeast to ***1 possesses both protein Ser/Thr kinase and endoribonu clease (RNase) activities,and initiates a key signaling branch of the *** ER stress,IRE1 is activated through trans-autophosphoryla tion and dimerization/oligomerization,resulting in the non-conventional splicing of XBP1 (X-box binding protein 1) mRNA to yield an active form of this transcription *** spliced form of XBP1 induces a major transcriptional program of the UPR.
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