Resveratrol(RES) is a natural polyphenolic compound commonly found in grapes, berries, peanuts and other traditional medicines that reported to be useful as treatment for a wide range of ***, whether resveratrol preve...
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Resveratrol(RES) is a natural polyphenolic compound commonly found in grapes, berries, peanuts and other traditional medicines that reported to be useful as treatment for a wide range of ***, whether resveratrol prevents Cd-induced Osteoporosis and the specific mechanism of anabolic action of RES remains largely ***, our present study indicated that cadmium chloride could inhibit MC3 T3-E1 cell proliferation and differentiation associated with decreased mRNA and protein levels of the differentiation markers alkaline phosphatase(ALP), collagen 1( COL1),bone morphogenetic protein-2(BMP-2) and runt-related transcription factor 2(RUNX2). On the contrary,we found that RES could promote MC3 T3-E1 cell proliferation and induce osteogenic differentiation. Interestingly, we demonstrated that RES significantly protected cadmiuminduced apoptosis of MC3 T3-E1 cells and attenuated cadmium-chloride inhibition of osteogenic differentiation via activation of the ERK1/2 signaling pathway.
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