Objective: The effect of Rhizoma typhonii, a traditional Chinese medicine herb, on human lymphocytes and tumors were studied in vitro. Methods: The effect of Rhizoma typhonii extract on the proliferation of human lymp...
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Objective: The effect of Rhizoma typhonii, a traditional Chinese medicine herb, on human lymphocytes and tumors were studied in vitro. Methods: The effect of Rhizoma typhonii extract on the proliferation of human lymphocytes and tumor cells were studied using [3H]-TdR incorporated method and MTT colorimetric method. The killer cell activity, natural
CKLFSF is a novel family of proteins linking chemokines and TM4SF (Transmembrane 4 Super Family). In human, they are encoded by nine genes, CKLF and CKLFSF1-8. Each CKLFSF member has a MARVEL domain, therefore, CKLFSF...
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CKLFSF is a novel family of proteins linking chemokines and TM4SF (Transmembrane 4 Super Family). In human, they are encoded by nine genes, CKLF and CKLFSF1-8. Each CKLFSF member has a MARVEL domain, therefore, CKLFSF1-8 were renamed CMTM1-8 ( CKLF-like MARVEL transmembrane domain containing member
T-Cell Receptor (TCR) binding to peptide-Human-Leukocyte-Antigens ( pHLAs) instigates T cell recognition. Here, we have expressed and refolded a panel of TCR molecules originating from human T cells that respond to na...
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T-Cell Receptor (TCR) binding to peptide-Human-Leukocyte-Antigens ( pHLAs) instigates T cell recognition. Here, we have expressed and refolded a panel of TCR molecules originating from human T cells that respond to naturally occurring disease epitopes, and their cognate pHLAs. We compare the binding of eight cytotoxic T lymphocyte (CTL) derived TCRs to pHLA-I with six T-helper cell (Th-cell) derived TCRs to pHLA-II using surface
Acute promyelocytic leukemia (APL) is the most malignant form of acute leukemia, associated with expression of the PML-RARα (promyelocytic leukemia-retinoic acid receptor-a) fusion protein. This fusion protein is tar...
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Acute promyelocytic leukemia (APL) is the most malignant form of acute leukemia, associated with expression of the PML-RARα (promyelocytic leukemia-retinoic acid receptor-a) fusion protein. This fusion protein is targeted by the differentiating agents all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3). Together with conven-
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