Objective:To investigate a possible association of specific polymorphisms of interleukin 1 (IL-1) receptor antagonist (IL-1ra) genes with susceptibility for BD with uveitis. Methods: A total of 27 BD patients and 71 h...
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Objective:To investigate a possible association of specific polymorphisms of interleukin 1 (IL-1) receptor antagonist (IL-1ra) genes with susceptibility for BD with uveitis. Methods: A total of 27 BD patients and 71 healthy controls were genotyped for IL-1ra variable number of tandem repeat polymorphisms (for five different alleles) by PCR. X2-analysis was used to compare the allele and geno-
Antigen-specific T cells occur in low frequencies in peripheral blood. This holds particularly true for chronic infections, including hepatitis B and C, HIV or tuberculosis, autoimmune diseases, as well as states afte...
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Antigen-specific T cells occur in low frequencies in peripheral blood. This holds particularly true for chronic infections, including hepatitis B and C, HIV or tuberculosis, autoimmune diseases, as well as states after DNA-or subunit vaccinations. Cytokine ELJSPOT assays have become the forerunners for T cell monitoring in vivo because they have detection limits around 1:100,000 cells and lower, exceeding by far the detection limit of flow cytometry-
Object: Sublytic C5b-9 has been described as a pro-inflammatory mediator that triggers cell activation rather than inducing cell death. Dendritic cells (DCs) play a critical role in controlling antigen specific immune...
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Object: Sublytic C5b-9 has been described as a pro-inflammatory mediator that triggers cell activation rather than inducing cell death. Dendritic cells (DCs) play a critical role in controlling antigen specific immune responses. Although DC maturation induced by various stimuli has been characterized, the role of C5b-9 on DC function has not been described.
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