Antigen-specific T cells occur in low frequencies in peripheral blood. This holds particularly true for chronic infections, including hepatitis B and C, HIV or tuberculosis, autoimmune diseases, as well as states afte...
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Antigen-specific T cells occur in low frequencies in peripheral blood. This holds particularly true for chronic infections, including hepatitis B and C, HIV or tuberculosis, autoimmune diseases, as well as states after DNA-or subunit vaccinations. Cytokine ELJSPOT assays have become the forerunners for T cell monitoring in vivo because they have detection limits around 1:100,000 cells and lower, exceeding by far the detection limit of flow cytometry-
p38 plays a central role in inflammation primarily through mediating the expression of inflammatory molecules, therefore p38 is an obvious target for therapy of inflammatory diseases. p38 inhibitors have been shown to...
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p38 plays a central role in inflammation primarily through mediating the expression of inflammatory molecules, therefore p38 is an obvious target for therapy of inflammatory diseases. p38 inhibitors have been shown to have anti-inflammatory effects in preclinical disease models. Several promising compounds have also progressed to clinical tri-
Recently several reports have shown that L-ficolin can activate the lectin complement pathway and is a pattern recognition molecule that specifically binds to clinically important microorganism, including Salmonella t...
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Recently several reports have shown that L-ficolin can activate the lectin complement pathway and is a pattern recognition molecule that specifically binds to clinically important microorganism, including Salmonella typhimuri-um, Streptococcus pneumoniae and Staphylococcus aureus in vitro. However, little is known about the roles and mechanisms of L-ficolin in protection against microorganisms infection in vivo. In this study. human L-ficolin cDNA
Myc/Max/Mad often play pivotal roles in the proliferation, apoptosis,differentiation and cell cycle progress of leukemia cells. Myc and Mad are known to be unstable proteins and their expression is tightly regulated t...
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Myc/Max/Mad often play pivotal roles in the proliferation, apoptosis,differentiation and cell cycle progress of leukemia cells. Myc and Mad are known to be unstable proteins and their expression is tightly regulated throughout cell cycle progression and differentiation. Usually, c-Myc expression is implicated in cell growth and proliferation, and the deregulated expression of c-Myc in both myeloid leukemia cells and normal myeloid cells not only blocks
Mesangioproliferative glomerulonephritis ( MPGN) is a disease of high incidence in humans. Rat Thy-1 nephritis (Thy-1 N) , namely, anti-thymocyte serum ( ATS)-induced nephritis is usually considerated to be an animal ...
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Mesangioproliferative glomerulonephritis ( MPGN) is a disease of high incidence in humans. Rat Thy-1 nephritis (Thy-1 N) , namely, anti-thymocyte serum ( ATS)-induced nephritis is usually considerated to be an animal model for studying MPGN. Although previous studies demonstrated that the glomerular mesangial cells (GMCs) injury was thought to be a feature of Thy-1 N, the mechanism of the disease (i. e. GMCs apoptosis) remains unclear.
T-bet, a Th1-specific transcription factor, can promote the production of IFN-γ. IFN-γis the principal Th1 effector cytokine and it has a crucial role in Th1 differentiation, which can drive the differentiation of n...
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T-bet, a Th1-specific transcription factor, can promote the production of IFN-γ. IFN-γis the principal Th1 effector cytokine and it has a crucial role in Th1 differentiation, which can drive the differentiation of naive CD4+ T cells into T-helper 1 (Th1) cells. Based on gene transfer, the safety problem and how to efficiently control the tar-
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