Objective:To explore the effect of arsenic trioxide( As2O3) in inhibition of proliferation and induction of apop-tosis of gastric cancer cell FU-97. we also investigated the relationship between AFP expression and VEG...
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Objective:To explore the effect of arsenic trioxide( As2O3) in inhibition of proliferation and induction of apop-tosis of gastric cancer cell FU-97. we also investigated the relationship between AFP expression and VEGF and STAT3 in gastric cancer cell FU-97.
Interleukin 24 (IL-24) is a new member of the IL-10 family of cytokines with cancer specific growth suppressing and cytokine properties. It remains unclear that whether IL-24 plays important roles in resistance to the...
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Interleukin 24 (IL-24) is a new member of the IL-10 family of cytokines with cancer specific growth suppressing and cytokine properties. It remains unclear that whether IL-24 plays important roles in resistance to the infection of pathogens. In this study, a human IL-24 cDNA with 621-bp in full length was cloned into the eukaryotic expression plasmids pCDNA3. 1 (-)/Myc-His A and pEGFP-C1, respectively. The plasmid encoding hIL-24 mutant was
Mice homozygous for a mutation in a single tyrosine residue (Y136) of the LAT adaptor showed impeded T cell development. However, later in life they accumulated polyclonal Th2 CD4 + effector T cells, which resulted in...
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Mice homozygous for a mutation in a single tyrosine residue (Y136) of the LAT adaptor showed impeded T cell development. However, later in life they accumulated polyclonal Th2 CD4 + effector T cells, which resulted in tissue eosinophilia and massive maturation of B cells into plasma cells secreting high level IgG1 and IgE. Little is known on the molecular mechanism leading to this unusual phenotype.
Mesangioproliferative glomerulonephritis ( MPGN) is a disease of high incidence in humans. Rat Thy-1 nephritis (Thy-1 N) , namely, anti-thymocyte serum ( ATS)-induced nephritis is usually considerated to be an animal ...
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Mesangioproliferative glomerulonephritis ( MPGN) is a disease of high incidence in humans. Rat Thy-1 nephritis (Thy-1 N) , namely, anti-thymocyte serum ( ATS)-induced nephritis is usually considerated to be an animal model for studying MPGN. Although previous studies demonstrated that the glomerular mesangial cells (GMCs) injury was thought to be a feature of Thy-1 N, the mechanism of the disease (i. e. GMCs apoptosis) remains unclear.
T-bet, a Th1-specific transcription factor, can promote the production of IFN-γ. IFN-γis the principal Th1 effector cytokine and it has a crucial role in Th1 differentiation, which can drive the differentiation of n...
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T-bet, a Th1-specific transcription factor, can promote the production of IFN-γ. IFN-γis the principal Th1 effector cytokine and it has a crucial role in Th1 differentiation, which can drive the differentiation of naive CD4+ T cells into T-helper 1 (Th1) cells. Based on gene transfer, the safety problem and how to efficiently control the tar-
Recently several reports have shown that L-ficolin can activate the lectin complement pathway and is a pattern recognition molecule that specifically binds to clinically important microorganism, including Salmonella t...
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Recently several reports have shown that L-ficolin can activate the lectin complement pathway and is a pattern recognition molecule that specifically binds to clinically important microorganism, including Salmonella typhimuri-um, Streptococcus pneumoniae and Staphylococcus aureus in vitro. However, little is known about the roles and mechanisms of L-ficolin in protection against microorganisms infection in vivo. In this study. human L-ficolin cDNA
Like anti-Fas monoclonal antibodies, some monoclonal antibodies against tumor necrosis factor-related apopto-sis-inducing ligand (TRAIL) receptors have tumoricidal activity too. Here we report a novel mouse anti-human...
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Like anti-Fas monoclonal antibodies, some monoclonal antibodies against tumor necrosis factor-related apopto-sis-inducing ligand (TRAIL) receptors have tumoricidal activity too. Here we report a novel mouse anti-human DR5 monoclonal antibody, AD5-10, that induces apoptosis of various tumor cell lines in the absence of second cross-linking in vitro and showed strong tumoricidal activity in vivo. AD5-10 does not compete with TRAIL for bind-
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