Like anti-Fas monoclonal antibodies, some monoclonal antibodies against tumor necrosis factor-related apopto-sis-inducing ligand (TRAIL) receptors have tumoricidal activity too. Here we report a novel mouse anti-human...
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Like anti-Fas monoclonal antibodies, some monoclonal antibodies against tumor necrosis factor-related apopto-sis-inducing ligand (TRAIL) receptors have tumoricidal activity too. Here we report a novel mouse anti-human DR5 monoclonal antibody, AD5-10, that induces apoptosis of various tumor cell lines in the absence of second cross-linking in vitro and showed strong tumoricidal activity in vivo. AD5-10 does not compete with TRAIL for bind-
The molecular mechanisms of hepatocellular carcinoma (HCC) with a striking higher prevalence in male remain to be fully elucidated. We here report the differentially expression of androgen receptor (AR) in different H...
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The molecular mechanisms of hepatocellular carcinoma (HCC) with a striking higher prevalence in male remain to be fully elucidated. We here report the differentially expression of androgen receptor (AR) in different HCC cells and normal hepatocytes. AR agonist dihydrotestosterone (DHT) can promote HCC cell growth and apop-totic resistance, whereas AR antagonist can significantly block the effects of DHT on the HCC cells. Paternally Ex-
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