4-1BB, a member of the TNFR superfamily, is a costimulatory receptor primarily expressed on activated T cells and professional antigen presenting cell (APC). It has been shown that the administration of agonistic anti...
详细信息
4-1BB, a member of the TNFR superfamily, is a costimulatory receptor primarily expressed on activated T cells and professional antigen presenting cell (APC). It has been shown that the administration of agonistic anti-4-1BB Abs enhances tumor immunity and allogenic immune responses. Using two novel anti-4-1BB monoclonal antibodies (mAb, 6F9 and 7D6 named after here) prepared in our laboratory, we showed the time-course model of 4-
Myc/Max/Mad often play pivotal roles in the proliferation, apoptosis,differentiation and cell cycle progress of leukemia cells. Myc and Mad are known to be unstable proteins and their expression is tightly regulated t...
详细信息
Myc/Max/Mad often play pivotal roles in the proliferation, apoptosis,differentiation and cell cycle progress of leukemia cells. Myc and Mad are known to be unstable proteins and their expression is tightly regulated throughout cell cycle progression and differentiation. Usually, c-Myc expression is implicated in cell growth and proliferation, and the deregulated expression of c-Myc in both myeloid leukemia cells and normal myeloid cells not only blocks
Interleukin -24 (IL-24) belongs to the IL-10 cytokine family. Delivery of human IL-24 gene into a variety of cancer cells can suppress their growth and trigger apoptosis. It remains unclear that whether human IL-24 ca...
详细信息
Interleukin -24 (IL-24) belongs to the IL-10 cytokine family. Delivery of human IL-24 gene into a variety of cancer cells can suppress their growth and trigger apoptosis. It remains unclear that whether human IL-24 can protect host against intracellular bacteria infection. In this study, a human IL-24 cDNA with 621-bp in full length was
Object: Sublytic C5b-9 has been described as a pro-inflammatory mediator that triggers cell activation rather than inducing cell death. Dendritic cells (DCs) play a critical role in controlling antigen specific immune...
详细信息
Object: Sublytic C5b-9 has been described as a pro-inflammatory mediator that triggers cell activation rather than inducing cell death. Dendritic cells (DCs) play a critical role in controlling antigen specific immune responses. Although DC maturation induced by various stimuli has been characterized, the role of C5b-9 on DC function has not been described.
p38 plays a central role in inflammation primarily through mediating the expression of inflammatory molecules, therefore p38 is an obvious target for therapy of inflammatory diseases. p38 inhibitors have been shown to...
详细信息
p38 plays a central role in inflammation primarily through mediating the expression of inflammatory molecules, therefore p38 is an obvious target for therapy of inflammatory diseases. p38 inhibitors have been shown to have anti-inflammatory effects in preclinical disease models. Several promising compounds have also progressed to clinical tri-
暂无评论