Myc/Max/Mad often play pivotal roles in the proliferation, apoptosis,differentiation and cell cycle progress of leukemia cells. Myc and Mad are known to be unstable proteins and their expression is tightly regulated t...
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Myc/Max/Mad often play pivotal roles in the proliferation, apoptosis,differentiation and cell cycle progress of leukemia cells. Myc and Mad are known to be unstable proteins and their expression is tightly regulated throughout cell cycle progression and differentiation. Usually, c-Myc expression is implicated in cell growth and proliferation, and the deregulated expression of c-Myc in both myeloid leukemia cells and normal myeloid cells not only blocks
Mesangioproliferative glomerulonephritis ( MPGN) is a disease of high incidence in humans. Rat Thy-1 nephritis (Thy-1 N) , namely, anti-thymocyte serum ( ATS)-induced nephritis is usually considerated to be an animal ...
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Mesangioproliferative glomerulonephritis ( MPGN) is a disease of high incidence in humans. Rat Thy-1 nephritis (Thy-1 N) , namely, anti-thymocyte serum ( ATS)-induced nephritis is usually considerated to be an animal model for studying MPGN. Although previous studies demonstrated that the glomerular mesangial cells (GMCs) injury was thought to be a feature of Thy-1 N, the mechanism of the disease (i. e. GMCs apoptosis) remains unclear.
T-bet, a Th1-specific transcription factor, can promote the production of IFN-γ. IFN-γis the principal Th1 effector cytokine and it has a crucial role in Th1 differentiation, which can drive the differentiation of n...
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T-bet, a Th1-specific transcription factor, can promote the production of IFN-γ. IFN-γis the principal Th1 effector cytokine and it has a crucial role in Th1 differentiation, which can drive the differentiation of naive CD4+ T cells into T-helper 1 (Th1) cells. Based on gene transfer, the safety problem and how to efficiently control the tar-
Like anti-Fas monoclonal antibodies, some monoclonal antibodies against tumor necrosis factor-related apopto-sis-inducing ligand (TRAIL) receptors have tumoricidal activity too. Here we report a novel mouse anti-human...
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Like anti-Fas monoclonal antibodies, some monoclonal antibodies against tumor necrosis factor-related apopto-sis-inducing ligand (TRAIL) receptors have tumoricidal activity too. Here we report a novel mouse anti-human DR5 monoclonal antibody, AD5-10, that induces apoptosis of various tumor cell lines in the absence of second cross-linking in vitro and showed strong tumoricidal activity in vivo. AD5-10 does not compete with TRAIL for bind-
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