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检索条件"任意字段=中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会"

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Identification of basal body proteins and functional analysis via RNAi in Trypanosoma brucei

Identification of basal body proteins and functional analysi...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Xiao-Kun Hong Zhao-Rong Lun De-Hua Lai Center for Parasitic Organisms State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-Sen university

Trypanosoma brucei is a unicellular eukaryote and the causative agent of human sleeping sickness and Nagana disease in *** genome of *** is organized into a disc-like structure,called *** kinetoplast is attached to the basal body of flagellum,via a set of filaments across mitochondrial *** body is a microtubule organizing center,which plays a crucial role in cell development and pathogenicity of trypanosomes in hosts,and is corresponding to centrosome of *** the essential function of basal body in trypanosomes,few basal body proteins has been identified and characterized,so *** this study,we aim to identify novel basal body proteins and dissect their biological *** on our lab previous work,we identified three potential basal body proteins(P620,P1400,P5420) through in-situ tagging,immunofluorescence and western blot.N-terminus YFP and C-terminus YFP recombinant proteins were localized to the basal body in both bloodstream(SMOX B4 background) and procyclic(SMOX P9 background) cell *** also performed RNAi experiments in SMOX P9 to analyze growth *** of P620 resulted in growth inhibition within 2 days post tetracycline induction,while growth inhibition was observed in RNAi of P1400 on day *** significant inhibition was observed in P5420 knockdown,*** plan to assess RNAi effect on basal body replication and separation,using western blot and ***,we have acquired sufficient amount of these protein through prokaryotic expression,which will be used for monoclonal antibody generation to confirm localization in near future.

关键词： Trypanosoma brucei basal body protein RNAi

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A novel potential oral trypanocide

A novel potential oral trypanocide

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Xiao-Li Cai Xuan Zhang Li-Ping Duan De-Hua Lai Zhao-Rong Lun Center for Parasitic Organisms School of Life SciencesSun Yat-sen University Chinese Center for Disease Control and Prevention

Trypanosoma brucei is a zoonotic haemoflagellate protozoan,causing both human African trypanosomiasis(HAT,caused by *** and ***) and animal Nagana disease(caused ***).African trypanosomiasis(HAT and Nagana disease) is one of the major tropical diseases which is committed by WHO and OIE to control and *** there are few approved drugs available for the treatment of HAT,these drugs not only must be delivered in hospital,but also cause severe side *** addition,most trypanocides can’t pass the blood brain barrier,thus can’t be used for the late stage of *** two drugs are recognized by WHO to treat the late stage of *** one of them cause up to 10% mortality(Melcy),and the other one(DFMO) must be taken at least two weeks for clinic treatment by IV in ***,development of oral administration trypanocides is urgently *** on the previous study on the effect of carbazole on trypanosomes,52 compounds were designed and *** of them,H1402 showed significant anti-trypansosomal activity on *** Lister 427 strain with a IC50 value at 17.2-20.2 μM in *** damage to mammalian cell(rat embryo fibroblasts) with the IC50 was not *** from in vivo experiments with mouse model by oral administration at 200 mg and 100 mg/kg/day for five days respectively,no parasite was detected within 30 days after *** control group of mouse,they died within 3-5 days after infection with this trypanosome without ***,we found that this compound(H1402) could also kill other animals tryanosomes such as ***,*** and *** both in vitro and in *** conclusion,compound H1402 showed a strong ability to kill *** and animal trypanosomes with the oral administration and may be a great potential compound to develop an oral trypanocide.

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The involvement of vacuolar ATPase to normal human serum APOL-1 mediated trypanolysis in Trypanosoma brucei

The involvement of vacuolar ATPase to normal human serum APO...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Zhi-Shen Xu De-Hua Lai Zhao-Rong Lun Center for Parasitic Organisms School of Life SciencesSun Yat-Sen University

Trypanosoma brucei is the unicellular causative agent of African sleeping sickness in humans and nagana in cattle.70 million African inhabitants of 36 sub-Saharan countries are exposed to infection in epidemic *** are three subspecies of Trypanosoma brucei,the human-infective pathogens *** and ***,which causes chronic form trypanosomiasis and acute form trypanosomiasis,respectively,and *** causes only *** is sensitive to the trypanolytic factor apolipoprotein L1(APOL1) in normal human *** previous studies showed the trypanolysis was caused by cytoplasmic swelling subsequent to the insertion of APOL1 into endosomal membranes,the exact mechanism of APOL1 function remains not ***,vacuolar ATPase has been linked to trypanolysis in a genome-scale RNA interference *** ATPase is an important physiological functioning complex,which is responsible for osmoregulation and organelle p H adjusting in *** found that V-ATPase displays a peculiar dual subcellular localization in acidocalcisomes and early *** behaviors arises in V-ATPase subunit B gene knockout bloodstream form trypanosomes,which results in reduced pathogen virulence: alkalization in acidocalcisomes,cells arrest at pre-cytokinesis stage,oxygen consumption rate diminished by 35%,defects in endocytosis and differentiation capability *** also found the decreased ingestion of APOL1 was companied with the endocytosis defect,which is potential key for the parasites’ resistance to normal human serum *** all,our comprehensive study uncovered the biological functions of V-ATPase and the involvement of V-ATPase during the APOL1-mediated trypanolysis in Trypanosoma brucei.

关键词： Trypanosoma brucei V-ATPase APOL-1 endocytosis acidocalcisome

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The study of immunogencity of transgenic Eimeria necatrix expressing the interleukin-2-Fc fusion proteins

The study of immunogencity of transgenic Eimeria necatrix ex...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Chunhui Duan Jingxia Suo Xinming Tang Si Wang Xianyong Liu Xun Suo National Animal Protozoal laboratory & College of Veterinary Medicine China Agricultural University

Eimeria *** the most common protozoan pathogens of *** coccidiosis could be controlled by vaccination,some low immunogenic Eimeria *** provide partial protection,especially *** recent study,some researchers find the interleukin-2-Fc fusion proteins have a potential effect to enhance host immune response to ***,we assumed that interleukin-2-Fc fusion proteins would show similar activity in Eimeria,And we obtained a transgenic *** expressing the interleukin-2-Fc fusion proteins by 4 generations of *** this study,two groups of chikens were immunized with 100 oocysts of En IL2 Fc(group 1) and En WT(group 2),*** found the oocyst output of En IL2 Fc was 2.6 x10～6,which was lower than that of the wild-type(4.85 x10～6).But when chickens were challenged with 1000 wild-type oocysts,the oocyst output of group 1 was higher than that of group 2,which was 6 x10～6 and 2 x10～6,***,we detected the expression level of three cytokine by q *** we find the expression level of IL-4,IL-2 and IFN-γ of birds in group 1 was slightly higher than those of birds in group 2 after *** together,our study indicated that the transgenic *** expressing the interleukin-2-Fc fusion proteins stimulated a slight different immune response,compared with the wild-type *** the study of immunogencity transgenic *** constitutes a basis for developing novel vaccines.

关键词： transgenic immunogencity interleukin-2 fusion Fc

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De novo transcriptome sequencing and transcript profile of the Thelazia callipaeda vector

De novo transcriptome sequencing and transcript profile of t...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Minghui Zheng Lingjun Wang Xiaohong Ren Lufei Zhang Fangli He Jianping Cao Hui Liu Yujuan Shen Zunyi Medical University National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention Qiannan Medical College For Nationalities

Background: Thelazia callipaeda(***),also called the oriental eyeworm,is common in Asia and *** Amiota(Phortica) okadai is the major *** vector of China and Southeast *** control is one of the most effective measures to prevent *** ***,there is little transcriptome information available for the *** vector in the public ***: Herein,we performed comprehensive and complete transcriptome sequencing of pooled c DNA prepared from eggs,larvae,male adults and female adults,and assembled into *** their functional annotation,homology,codon usage bias and simple sequence repeats(SSRs) were then ***: Approximately 77,375,066 million clean reads were obtained,after trimmed and assembled,38,504 unigenes with an average length of 571 bp,an N50 of 711 bp,and an average GC content 51.26%,were *** them,76.5% of unigenes could be mapped onto the reference genome,and 69% of unigenes could be annotated with known biological *** analysis identified certain numbers of Phortica okadaiunigenes that showed homology or being putative 1:1 orthologues with genomes of other Dipteran *** usage bias was analyzed and 1,904 SSRs were detected,which will provide effective molecular markers for the population genetics of this ***: Our data not only serve as most comprehensive transcriptomic resources for future functional genomics studies to understand the molecular aspects of Phortica okadai,but also will facilitate genetic,genomic studies,and further vector control of Thelazia callipaeda.

关键词： Transcriptome RNA-Seq Phortica okadai Codon usage bias Simple sequence repeat Vector control

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Genetic and biological similarity of Cyclospora cayetanensis to cecum-infecting Eimeria *** revealed by comparative genomic analysis

Genetic and biological similarity of Cyclospora cayetanensis...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Shiyou Liu Yaqiong Guo Kevin Tang Dawn M.Roellig Yaoyu Feng Lihua Xiao School of Veterinary Medicine South China Agricultural University

Cyclospora cayetanensis is an emerging foodborne parasite that has received high attentions because of the massive foodborne outbreaks they caused in recent *** investigation of foodborne outbreaks of cyclosporiasis has been hampered by a lack of genetic data and poor understanding of pathogen *** sequenced the whole genome of *** from a patient in China using Illumina 100-bp paired-end *** apicoplast and mitochondrial genomes of *** are highly similar to those of cecum-infecting avian Eimeria *** both gene organization and sequences.A comparative analysis of the nuclear genomes has confirmed the similarities in genome organization,metabolic capabilities and potential invasion mechanism between *** and Eimeria ***-Co A degradation,GPI anchor biosynthesis,and N-glycosylation are some apparent metabolic differences between *** and *** similar repertoire of host cell invasion-related proteins possessed by all coccidia suggests that *** has an invasion process similar to the one in *** and ***,the significant reduction in the number of identifiable rhoptry protein kinases,phosphatases and serine protease inhibitors indicates that monoxenous coccidia,especially ***,have limited capabilities or use a different system to regulate host cell nuclear *** does not possess any cluster of genes encoding the TA4-type SAG surface antigens seen in ***,and may use a different family of surface antigens in initial host cell *** on the whole genome sequence data,a multilocus sequence typing tool was developed,with 2 to 10 geographically segregated sequence types at each of 5 selected *** new tool could be useful in case linkage and infection/contamination source tracking.

关键词： Cyclospora whole genome sequence genotyping tools outbreak investigation

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Dynamic transcriptomes identify biogenic amines and insect-like hormonal regulation for mediating reproduction in Schistosoma japonicum

Dynamic transcriptomes identify biogenic amines and insect-l...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Jipeng Wang Ying Yu Haimo Shen Tao Qing Yuanting Zheng Qing Li Xiaojin Mo Shuqi Wang Nana Li Riyi Chai Bin Xu Mu Liu Paul J.Brindley Donald P.McManus Zheng Feng Leming Shi Wei Hu State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology Collaborative Innovation Center for Genetics and DevelopmentSchool of Life SciencesFudan University National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionKey Laboratory of Parasite and Vector Biology of the Chinese Ministry of HealthWHO Collaborating Center for MalariaSchistosomiasis and Filariasis Department of Microbiology Immunology & Tropical Medicineand Research Center for the Neglected Diseases of PovertySchool of Medicine & Health SciencesGeorge Washington University

Eggs produced by the mature female parasite are responsible for the pathogenesis and transmission of *** schistosomes rely on a unique male-induced strategy to accomplish reproductive development,a process that is incompletely *** we map detailed transcriptomic profiles of male and female Schistosoma japonicum across eight time points throughout the sexual developmental process from pairing to *** dynamic gene expression pattern data reveal clear sex-related characteristics,indicative of an unambiguous functional division between males and females during their *** analysis,in situ hybridization and RNAi assays indicate that males likely use biogenic amine neurotransmitters through the nervous system to control and maintain pairing with *** addition,the analyses indicate that reproductive development of females involves an insect-like hormonal *** datasets and analyses serve as a foundation for deeper study of sexual development in this pathogen and identification of novel anti-schistosomal interventions.

关键词： Dynamic transcriptomes identify biogenic amines and insect-like hormonal regulation for mediating reproduction in Schistosoma japonicum

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Combined immunization with Eimeria intestinalis precocious line and Eimeria magna protects rabbits against challenge infection

Combined immunization with Eimeria intestinalis precocious l...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： LI Chao WANG Yunzhou TAO Geru GU Xiaolong SUO Xun LIU Xianyong College of Veterinary Medicine China Agricultural University

Eimeria intestinalis and *** are two of the most pathogenic species of coccidia which causes coccidiosis in *** develop live oocyst vaccines against rabbit coccidiosis,these two species should be in the *** this study,we immunized New Zealand white rabbits with oocysts of a precocious line of ***(Ei P) and a wild-type strain of ***(Em WT).The dose for group 1 is 500 Ei P and 100 Em WT;while the dose for group 2 is 1000 Ei P and 100 Em *** rabbits were challenged with 1×10～4 *** wild-type oocysts and 1×10～4 *** wild-type oocysts on day 12 post *** days 7 and 12 PI,mean body weight gain(BWG) of groups 1 and 2 were less than that of the non-infected control(P<0.05).BWG in group 2 was higher than that in group 1 on day 12(P<0.05),indicating that immunization with higher dose of Ei P may alleviate the impairment by Em *** challenge,BWG of rabbits in groups 1 and 2 were similar with that of the control ***,oocyst output of the two species in groups 1 and 2 was less than 4.0×105,significantly less than that of the unimmunized and challenged group(1.5×10～8)(P<0.01).These results demonstrate that immunization with *** and *** could provide protection against homologous *** study for selecting precocious line of *** may reduce the untoward effect of wild-type *** study encourages the development of attenuated live vaccines for rabbit coccidiosis.

关键词： Eimeria intestinalis E magna combined immunization precocious line

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Diclazuril-resistant Eimeria isolated from chicken farms in China

Diclazuril-resistant Eimeria isolated from chicken farms in ...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Zhenyan Han Feifei Bi Zhenkai Hao Sixin Zhang Xiaoli Tang Jingxia Suo Chao Li Chaoyue Wang Dandan Hu Chunhui Duan Guangping Huang Xun Suo Yonglan Yu Xianyong Liu College of Veterinary Medicine China Agricultural University

Chicken coccidiosis,which is caused by the infection of Eimeria species,is a severe diseases in poultry *** present,the prevention of chicken coccidiosis largely depends on anticoccidial *** is widely used in the field for a long time and thus raised the heavy problem of drug *** the drug-resistant strains isolated from the field are valuable for studying the molecular mechanisms of drug resistance,we carried out the collection and isolation of diclazuril-resistant strains in this *** fecal samples were collected from 60 chicken farms in Guangdong,Shandong and Henan *** fecal samples were tested by Mac Master *** the test of the diclazuril resistance,the control group(infected and non-medicated) and the experimental group(infected and medicated with 1 mg/kg diclazuril) were set *** was added 48 h before infection and until the end of the *** fecal samples were collected from each group from day 5 to day 9 post *** relative oocyst production(ROP) was used as the drug resistance *** 40 samples were coccidia oocyst *** ROPs of 9 samples were greater than 15% when compared to a sensitive coccidia population,indicating they were resistant or partial resistant to *** them,3 are from Henan Province and 6 from Guangdong ***-resistant *** and *** were isolated by single-oocyst *** diclazuril resistant strains are valuable for the further study on the mechanism of chicken coccidiosis resistance,especially to diclazuril.

关键词： Eimeria chicken coccidia diclazuril drug resistance

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Analysis of gene expression profiles of sheep PBMCs stimulated with Haemonchus contortus extracts

Analysis of gene expression profiles of sheep PBMCs stimulat...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Si Wang Dandan Hu Chaoyue Wang Jingxia Suo Xun Suo Xianyong Liu National Animal Protozoa Laboratory & College of Veterinary Medicine China Agricultural University

Haemonchus contortus,the blood-feeding gastrointestinal parasite,is a major constraint on ruminant health and production *** occurrences of antiparasitic-resistant strains exacerbate the control of ***,the development of vaccines against *** is an alternative *** order to gain further understanding of host immune responses to ***,we examined the gene expression profiles of sheep PBMCs stimulated with *** extracts(Hc Ag).Differential expression analysis revealed that the expression of a substantial number of genes changed significantly after *** analysis of the genes concerning germline-encoded receptors revealed increased transcription of CLEC2 L and NLRP3 after Hc Ag *** for the genes involved in signaling cascades,we found that ATF3,a negative regulatory transcription factor in TLR and CLR pathways,increased significantly,which may account for the mild expression profile of inflammatory ***,we examined which component of *** extracts may play a key role in regulating the expression of immune-related genes of sheep *** found that stimulation with proteinase K-treated Hc Ag could also increase the expression of CLEC2 L,NLRP3,ATF3 and most effector molecules of sheep PBMCs,but not by the stimulation with periodate-treated Hc *** real-time PCR also confirmed this expression ***,we proposed that carbohydrate-containing molecules in *** extracts could stimulate sheep PBMCs to upregulate CLEC2 L and NLRP3,then signaling through ATF3 to regulate the expression of cytokines and *** research may give a hint to identify vaccine candidates against *** infection.

关键词： Haemonchus contortus sheep PBMCs CLEC2L NLRP3 ATF3

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