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检索条件"任意字段=中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会"

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A recombinant multi-epitope vaccine induced T follicular helper cells for the enhancement of humoral immunity against Trichinella spiralis

A recombinant multi-epitope vaccine induced T follicular hel...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Yuan Gu Bo Li Ximeng Sun Xinping Zhu Department of Medical Microbiology and Parasitology School of Basic Medical SciencesCapital Medical University

Background: As one of the most popular parasitic zoonoses,Trichinellosis is eliminated through humoral immunity in a great deal.T follicular helper cells（Tfh） are a newly identified CD4 T cells subset which plays an important role in providing of cognate B cell *** cells are critical for humoral immunity,including the generation of long-lived and high affinity plasma cells and memory cells which are crucial for long-term protection against *** previous studies have identified that mice immunized with a recombinant multi-epitope vaccine（r MEP） with Th2 epitope and B cell epitope in series produced long-term antibody responses and protective immunity against Trichinella spiralis *** is speculated that Tfh cells may play an important role in supporting B cell responses and the aim of this study is to explore the mechanism of Tfh in humoral responses induced by r ***: Female BALB/c mice were subcutaneously immunized with r MEP emulsified with ISA 50 V2 adjuvant.r MEP-specific IgG,IgG1 and IgG2 a antibody responses were assessed by *** cells of spleen and inguinal lymph nodes,GC B cells and memory B cells of splenocytes were analysed by flow ***: r MEP induced high levels of anti-r MEP specific IgG and subclass IgG1 and IgG2 a,with IgG1 *** to the control,Tfh cells of spleen and inguinal lymph nodes,GC B cells and memory B cells of splenocytes,as well as the IL-4,IFN-γ and IL-21 Tfh cells,increased in r MEP immunized group,as analysed by flow ***: r MEP induced a mixed Th1/Th2 immune response in mice,with Th2 *** cells,GC B cells as well as memory B cells induced by r MEP played an important role in generating long-lasting and effective humoral immune responses.

关键词： Trichinella spiralis humoral immunity T follicular helper cells multi-epitope vaccine

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Identification and characterization of Eimeria tenella autophagy marker protein ATG8

Identification and characterization of Eimeria tenella autop...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Qi Nanshan Liao Shenquan Li Juan Lv Minna Wu Caiyan Lin Xuhui Hu Junjing Yu Linzeng Liu Baozhen Xiao Wenwan Sun Mingfei Li Guoqing College of Veterinary Medicine South China Agricultural University Institute of Animal Health Guangdong Academy of Agricultural Sciences

Autophagy is a "self-eating" process in eukaryotic cells involved in the targeted degradation of damaged or senescent cells,organelles,denatured proteins,nucleic acids and other biological macromolecules to maintain the cell *** now,about 35 conserved autophagy-related genes have been identified in yeast and mammalian study,but there were no reports about autophagy study in Eimeria *** our early study,about 11 orthologs of autophagy genes were found in the *** genome database,including the autophagy marker atg8,which is conserved from apicomplexan to *** this study,Etatg8,a 375 bp open reading frame encoding a protein of 124 amino acids was identified from ***,which was highly conserved from Eimeria to *** q RT-PCR and western blotting results revealed the Etatg8 gene was expressed in all four developmental stages(unsporulated oocysts,sporulated oocysts,sporozoites and second-generation merozoites),but the transcript level was significant higher at unsporulated oocyst stage than other three *** immunofluorescence assay(IFA) showed that the Et ATG8 was generally distributed throughout the cytosol of sporozoites and merozoites in complete Dulbecco's modified Eagle medium(DMEM).After incubation in Hank's balanced salt solution(HBSS) or DMEM with autophagy inducer of rapamycin or monencin,the sporozoites and merozoites displayed one and more punctuate Et ATG8 positive signal in the apical ***,our results suggest that Et ATG8 was an autophagy marker protein,which might play an important role in the autophagy of ***.

关键词： Eimeria tenella Autophagy related gene atg8 Cloning and expression qRT-PCR and western blotting Immunofluorescence assay

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Deltamethrin exposure induced alteration of amino acids level in the wild deltamethrin-resistant strain of Aedes albopictus

Deltamethrin exposure induced alteration of amino acids leve...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Ruili Xie Lianfen Huang Lilan Peng Xiaoguang Chen Hua Li Department of Pathogen Biology & Experimental teaching center of preventive medicine School of Public HealthSouthern Medical University

Objective Observe the level alteration of amino acids in aedes albopictus larvae undergoing deltamethrin exposure in oder to explore the biomarkers related to deltamethrin toxic ***: The Aedes albopictus larvae were collected from the Yuexiu district of Guangzhou city where was reported that the mosquitoesare highly resistant to *** F1 generation larvae were determined deltamethrin resistance according to WHO recommended detection method and were treated with 0.035 ppm deltamethrin(dissolved in acetone) and acetone respectively(10 larvae in each group).The amino acids level in the larvae before and after deltamethrinand acetone exposure were detected by LC-MS/MS,and 6 times repeated detection were completed for each ***: The LC50 of the F1 generation larvae of the wild strain aedes albopictus was 0.064806 ppm,which reached 10.249 times of that of the sensitive strain(LC50=0.006323 ppm).It can be identified as resistant strain according to WHO criteria(more than 5 times).There were 11 of the 17 common amino acids showed differences in level post drug exposure(p<0.05) in the larvae by LC-MS/MS test,in which,the level of 10 amino acids(alanine,citrulline,glutamate,glycine,leucine,ornithine,phenylalanine,proline,serine,threonine) reduced and the level of histidineelevated after exposure(p<0.05).The level alteration of 7 amino acids( glutamate,glycine,ornithine,proline,serine,threonine and histidine) were related to acetone exposure(p<0.05) and the level reduction of 4 amino acids(alanine,citrulline,leucine and phenylalanine) were attributed to deltamethrin exposure(p<0.05) eliminated the effect of ***: Both deltamethrin and acetone may act the effect factors of the level alteration of amino acids in the Aedes albopictus larvae,and deltamethrin exposure could result in the level alteration of alanine,leucine,phenylalanine and citrulline in the *** 4 amino acids might become thecandidate biomarkers for deltamethri

关键词： deltamethrin Aedes albopictus resistance amino acids

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miRNA profiling of Protoscoleces in Echinococcus granulosus

miRNA profiling of Protoscoleces in Echinococcus granulosus

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： WANG Zheng-rong BO Xin-Wen ZHANG Yan-Yan Ma Xun Wang Zhi-Xin Lu Ping-Ping Meng Ji-meng State Key Labaratory of Sheep Genetic Improvement and Healthy Production/Institute of Animal Husbandry and Veterinary Xinjiang Academy of Agricultural and Reclamation Sciences College of Animal Science and Technology Shehezi University College of Veterinary Medicine China Agricultural University

A peculiar feature of the biology of *** is that the protoscolex has the potential to develop in either of two *** ingested by a dog will develop in a sexual direction to form adult tapeworms in the definitive host *** contrast,if a hydatid cyst ruptures within the intermediate or human host,each released PSC is capable of differentiating asexually into a new hydatid *** unique developmental phenomenon has been well known,but up to date,the regulation mechanism behind the phenomenon is little *** RNAs are endogenous small non encoding RNA molecules,which plays a pivitol role in the animal's post transcriptional regulation *** order to explore the role of mi RNA in the PSC development process,the present study analyzed the mi RNA profiling of *** PSC by RNA *** results showed that there are 109 known mi RNAs and 189 novel mi RNA hairpin precursors detected in the PSC of the *** target genes prediction of these mi RNAs suggested that they are widely involved in the growth of the PSC related Key signaling pathways,such as Wnt,c AMP,Hedgehog,NF-κB,Notch,and bile acids signaling *** further research,the expression and distribution of mi RNAs and thier canidated target genes,which are association with the key genes of classic wnt signaling ***,our findings suggested that there maybe a potential regulatory relationship between HG328413.16258 vs β-catenin,HG328414.16364* vs Dsh and HG328399.15846 vs *** summary,the results of the present study suggest that mi RNAs may participate in a wide range of developmental process in PSC,which needs a further verified.

关键词： miRNA Echinococcus granulosus protoscoleces expression profile target gene

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Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China

Seroprevalence of Toxoplasma gondii infection in arthritis p...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Ai-Ling Tian Yuan-Lin Gu Na Zhou Wei Cong Guang-Xing Li Hany M.Elsheikha Xing-Quan Zhu State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Veterinary Parasitology of Gansu ProvinceLanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences Weihaiwei People’s Hospital Affilliated Hospital of Medical College Qingdao University School of Basic Medicine Dali University Faculty of Medicine and Health Sciences School of Veterinary Medicine and ScienceUniversity of NottinghamSutton Bonington Campus

Background: There is accumulating evidence for an increased susceptibility to infection in patients with *** sought to understand the epidemiology of Toxoplasma gondii infection in arthritis patients in eastern China,given the paucity of data on the magnitude of *** infection in these ***: Seroprevalence of *** infection in 820 arthritic patients and an equal number of healthy controls,from Qingdao and Weihai cities,eastern China,was assessed by enzyme-linked immunosorbent assay using a crude antigen of the *** on sociodemographic,clinical and lifestyle characteristics of the study participants was also ***: The prevalence of *** Ig G was significantly higher in arthritic patients(18.8%) compared with 12% in healthy controls(P < 0.001).12 patients with arthritis had *** Ig M antibodies comparable with 10 of the controls(1.5% vs 1.2%).Demographic characteristics did not significantly influence these seroprevalence *** highest seropositivity rate of *** infection was detected in patients with rheumatoid arthritis(24.8%),followed by reactive arthritis(23.8%),osteoarthritis(19%),infectious arthritis(18.4%) and gouty arthritis(14.8%).Seroprevalence rates of rheumatoid arthritis and reactive arthritis were significantly higher when compared with controls(P < 0.00 and P < 0.05,respectively).A significant association was detected between the presence of cats in the home and *** infection in arthritic patients(odds ratio [OR],1.68;95% confidence interval [CI],1.24 to 2.28;P = 0.001).Conclusions: These findings are consistent with and extend previous results by providing more evidence to support the link between contact with cats and an increased risk of *** *** study also confirmed an association between *** infection and arthritis patients in China for the first *** for better prevention and control of *** infection in arthritis pati

关键词： Toxoplasma gondii Autoimmunity Arthritis Seroprevalence Risk factors

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Comparative transcriptome analysis of Eimeria necatrix third-generation merozoites and gametocytes reveals genes involved in sexual differentiation and gametocyte development

Comparative transcriptome analysis of Eimeria necatrix third...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Shijie Su Zhaofeng Hou Dandan Liu Chuanli Jia Lele Wang Jinjun Xu Jianping Tao College of Veterinary Medicine Yangzhou Universityand Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosesand Jiangsu Key Laboratory of Zoonosis

Eimeria necatrix is one of the most pathogenic parasites since it is associated with high mortality in chickens older than 8 *** life cycle of the parasite includes merogony(producing merozoites) and gametogony(sexual differentiation and producing gametocytes) and sporogony(forming sporulated oocysts).The resilient oocysts are transmitted between hosts in the ***-Seq transcriptome profiling offers insights into the mechanisms governing the sexual development of *** and the potential to identify targets for blocking parasite *** this study,we employ transcriptome analysis between third-generation merozoits(MZ-3) and gametocytes(GAM) of *** to identify gene with functions related to sexual differentiation and gametocyte development.A total of 7617 and 8091 unigenes were obtained from MZ-3 and GAM,*** 4267 genes were differentially expressed genes(DEGs) between MZ-3 and *** with MZ-3,2789 genes were upregulated and 1478 genes were downregulated in *** 329 genes in MZ-3 and 1289 genes in GAM were further identified to have stage-specific *** ontology category and KEGG analysis suggested that 542 upregulated genes in MZ-3 were annotated by 77 GO assignments,246 upregulated genes were associated with 174 signal pathways,while 953 upregulated genes in GAM were annotated by 170 GO assignments,405 upregulated genes were associated with 231 signal *** molecular functions of upregulated genes in GAM were mainly enriched for starch and sucrose metabolism,regulation of autophagy,fatty acid elongation,and fat digestion and *** also predicted 86 gametocyte upregulated genes,of which 53 involved in the biosynthesis of the oocyst wall,and 33 involved in microgametocyte *** the best of our knowledge,this is the first RNA-seq data study of the MZ-3 and GAM stages of *** study forms a basis for deciphering the molecular mechanisms underlying th

关键词： Eimeria necatrix Gametocytes Merozoites RNA-seq Comparative transriptomes Genes Sexual differentiation and development

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Studies on the Biological Characteristics and Fermentation

Studies on the Biological Characteristics and Fermentation

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Xiaorui Zhu Meng Liang Xinfang Wang Wenrui Wang Xiaoping Luo Lianru Yang Xiaoye Yang Rui Wang College of Veterinary Medicine Inner Mongolia Agricultural University Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences

Pochonia chlamydosporia is an important biocontrol *** fungus can be used to control not only plant parasitic nematodes but also animal parasitic *** has great potential to control parasitic *** order to obtain more information about *** *** morphological characteristics,fermentation broth and it’s effect on animal parasitic nematodes were *** results are listed as follows: The colony morphology growth rate of the fungus grew on the 0.4 g/L corn-meal-agar medium was slightly different with that grew on Savary-gilliard glucose agar *** colony radius was 2.4 cm on CMA and 3.0 cm on SDA,*** hyphae on the two medium were both radial,thick,and *** were single or verticillate born in *** conidiophore had 4 branches,and there was an oval or round transparent conidium on the top of each *** with thick wall was formed in the aged hyphae and each was brick lattice shape and *** Caenorhabditis elegans and eggs,Strongylus larvae and eggs,Ascaris suum eggs were put on the CMA medium surface with the *** results showed that the infection rate of the fungus to *** eggs and Strongylus eggs was only 2%;The fungus can break the eggshell and infect the eggs,and the infection rate was 29.6% after one *** different liquid medium were used to obtain fermentation broth of *** *** fermentation broth filtrations were collected,and the protein content,enzyme activity,phosphatase activity and so on were *** results showed that the indicators of the fermentation broth were also different in different *** protein content and enzyme activity of LMZ medium,which also had the highest inhibition rate to the tested nematodes,was the highest among the four and the corn was the lowest *** the study,the morphological characteristics,the effect on animal parasitic nematodes and growth in four different li

关键词： Pochonia chlamydosporia Conidiophore Chlamydospore Liquid Fermentation

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Metabolomic profiling of Eimeria tenella life cycle stages using liquid chromatography-mass spectrometry

Metabolomic profiling of Eimeria tenella life cycle stages u...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Shenquan Liao Nanshan Qi Caiyan Wu Juan Li Minna Lv Xuhui Lin Linzeng Yu Jianfei Zhang Mingfei Sun Institute of Animal Health Guangdong Academy of Agricultural SciencesOpen Laboratory of Veterinary Public Health and Key Laboratory of Livestock Disease Prevention of Guangdong Province

Purpose: The protozoan parasite Eimeria tenella,is considered one of the most pathogenic species and causes great economic loss to the poultry *** has a complex developmental life cycle including an exogenous phase in the environment and an endogenous phase in the *** the life cycle parasites need to adapt to different circumstances and undergo metabolism ***,little is known about the metabolic pathways in ***,especially the metabolite changes during the invasive *** conducted untargeted metabolomic analysis of four life cycle stages of ***(unsporulated oocyst,sporulated oocyst,sporozoite,and second-generation merozoite).Methods: Unsporulated oocysts of ***(Guangdong strain) were harvested from *** oocysts were sporulated in vitro for 48 *** were obtained from cleaned oocysts by in vitro excystation and purified over ***-generation merozoites were recovered from the caecal mucosa of chickens 120 h after *** purified samples were collected by centrifugation and frozen at-80 °C *** methanolic extracts were prepared and analyzed by Liquid Chromatography-Mass Spectrometry(LC-MS).Results: The metabolomics analysis detected approximately 933 metabolite *** partial least squares discriminant analysis(PLS-DA),a total of 20,56 and 74 differential metabolites were identified in the positive ion(ESI+) mode,34,33 and 46 differential metabolites were detected in the negative ion(ESI-) mode in sporulated oocyst,sporozoite and second-generation merozoite compared to unsporulated oocyst,*** these metabolites,41 were shared between sporozoite and second-generation merozoite compared to unsporulated oocyst in the ESI+ mode,and 17 were shared in the *** 58 differential metabolites were involved in carbohydrate metabolism,lipid metabolism,amino acid metabolism,cofactor and vitamin *** results showed the metabolic chan

关键词： Eimeria tenella metabolomic profiling liquid chromatography mass spectrometry

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Development of decoquinate-resistant coccidia

Development of decoquinate-resistant coccidia

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Feifei Bi Zhenyan Han Zhenkai Hao Sixin Zhang Xiaoli Tang Jingxia Suo Chao Li Chaoyue Wang Dandan Hu Chunhui Duan Guangping Huang Xun Suo Yonglan Yu Xianyong Liu College of Veterinary Medicine China Agricultural University

Coccidiosis,caused by the infection of Eimeria species,is one of the most common diseases in poultry industries *** application of anticoccidial drugs results in the development of drug resistance in chicken ***,study of the drug resistance of parasites isolated from field is necessary for the control of *** determine the initial concentration of decoquinate applied for the induction of resistance,we detected the oocyst output of chickens infected with 10/bird oocysts of an isolate from Shandong Province and fed with 1,5 and 25 mg/kg decoquinate,*** relative oocyst output of 1,5 and 25 mg/kg of decoquinate was 84%,42% and 0.2%,respectively,when compared to that of the non-medicated *** the initial concentration of decoquinate was 5 mg/*** 7-day-old SPF chickens were randomly assigned to 4 *** 1 were fed with decoquinate,while group 2 with double *** groups(infected without medication,non-infected without medication) were also set *** concentration increased from 5 mg/kg(1 st generation) to 10 mg/kg(2 generation),20 mg/kg(3 generation),30 mg/kg(4 and 5 generations),40 mg/kg(6 generation),50 mg/kg(7 generation) and 60 mg/kg(8 generation).In addition,we isolated ***,***,*** and *** decoquinate-resistant strains from oocysts of 8 generation by single-oocyst technique with plastic *** success of the isolation was conferred by polymerase chain reaction(PCR) amplification of the internal transcribed spacer 1(ITS-1) region of ribosomal DNA of *** decoquinate resistant strains obtained in this study is important for exploring the mechanism of coccidiosis resistance to decoquinate,for establishing the drug detection technology of coccidiosis,and for preventing and controlling the emergence of drug resistance.

关键词： Eimeria Decoquinate Drug-resistance

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Transgenic Eimeria tenella expressing profilin of *** elicits enhanced protective immunity against *** and alters gut microbiome of chickens

Transgenic Eimeria tenella expressing profilin of *** elicit...

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中国动物学会寄生虫学专业委员会第十六次全国学术会议暨第七次国际寄生虫学学术研讨会

作者： Xinming Tang Jingxia Suo Chao Li Mengze Du Chaoyue Wang Dandan Hu Chunhui Duan Yanli Lv Xianyong Liu Xun Suo College of Veterinary Medicine China Agricultural University

Coccidiosis,caused by apicomplexan parasites of the genus Eimeria,is one of the most serious diseases of livestock and poultry in the *** vaccination with live anti-coccidial vaccines is successful worldwide,vaccines formulated with genetically manipulated strains would improve the immunogenicity of the vaccine strains and thus be the best strategy for controlling coccidiosis in breeder and layer stocks even in fast growing *** from apicomplexan parasites is the well defined ligand for Toll-like receptor 11(TLR11) and TLR12,helps to propagate a host immune response through the activation of Interleukin 12,Interferon-alpha(IFN-α) and IFN-γ responses and is a potential molecular ***,we constructed a transgenic Eimeria tenella line(Et-Em Pro) expressing the profilin of ***,the most immunogenic species of chicken coccidia,and evaluated the adjuvant effects of Em Pro on the immunogenicity of *** found that immunization with Et-Em Pro,compared with the wild type,elicited greater specific cell-mediated immunity,characterized by more IFN-γ-secreting ***-Em Pro also induced better protective immunity against *** challenge,as shown by lower oocyst output,more body weight gains and lower scores of cecum lesion than the wild *** addition,we analyzed the community of fecal microbiota to study the interactions of Eimeria with gut microbiome of *** diversity of the fecal microbiome of the birds immunized with the transgenic parasite differed from birds immunized with wild type *** results of enhanced immunogenicity of *** by Em Pro as a molecular adjuvant derived from the most immunogenic affinis species are a big step forward in the development of the next generation coccidiosis vaccines using Eimeria as a vaccine platform expressing molecular adjuvants and potentially other pathogen antigens against not only coccidiosis but also other infectious diseases.

关键词： Transgenic Eimeria Adjuvants Immunogenicity Profilin Eimeria maxima Protective immunity Microbial community

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