Enzymatic kinetic resolution is a superior approach in terms of enantioselectivity and mild reaction conditions and widely applied in the production of pharmaceuticals and natural products *** by a practical accumulat...
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Enzymatic kinetic resolution is a superior approach in terms of enantioselectivity and mild reaction conditions and widely applied in the production of pharmaceuticals and natural products *** by a practical accumulation of chiral pent-2-enol derivatives in our ongoing natural product syntheses,we embarked on an enzymatic kinetic resolution of 2-alkylated cyclopent-2-enol and excellent enantioselectivities(up to 99%ee)were achieved on several interesting substrates after extensive screening on commercially available biocatalysts(see the following scheme).This practical and environmentally friendly approach is complementary to conventional metallo-and organocatalysis in chemical *** exciting progress on this topic in this laboratory would be presented.
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