Oxidation and amination of a sp3 C-H bond can quickly install an oxygen atom or an amino group on a carbon atom,and thus have attracted considerable attention,since most of the known drugs and natural products are oxy...
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Oxidation and amination of a sp3 C-H bond can quickly install an oxygen atom or an amino group on a carbon atom,and thus have attracted considerable attention,since most of the known drugs and natural products are oxygenand nitrogen-containing *** the best of our knowledge,there have been few reports on sp3 C-H bond activation reaction under the catalysis of high-valence rhenium *** now,only a few examples of C-H bond oxidation and none of the amination reaction catalyzed by rhenium(V)complexes have been reported.1,2 In our effort,we found intramolecular amination catalyzed by another rhenium complex[Re Cl2(Phen)(PPh3)2]+Re O4-.Selected examples are ***,when Ag Sb F6 was added,the time and temperature of the reaction obviously ***,the reaction will not go on catalyzed by only Ag Sb F6 without rhenium complex.
A novel selective fluorescent chemosensor based on a 2, 2'-Bisbenzimidazole derivative(L) was synthesized and characterized. Once combined with Fe3+, it displayed high specificity for fluoride anion. It can displa...
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A novel selective fluorescent chemosensor based on a 2, 2'-Bisbenzimidazole derivative(L) was synthesized and characterized. Once combined with Fe3+, it displayed high specificity for fluoride anion. It can display on-off-type fluorescence charged with high selectivity toward Fe3+ among 12 metal ions in H2O/DMSO(1:1, v/v) solutions. Furthermore, in the situ generated L-Fe3+ ensemble could recover the quenched fluorescence upon the addition of fluoride anion resulting in an off-on-type sensing with a detection limit of 1.0×10-9 mol/L in the same medium. Notably, the sensor was retrievable to indicate fluoride anions with Fe3+, and F-, in turn, increased.
It is reported that introduction of aromatic group into steroids has led to new physiological activities[1-3]. As continuation of our study on the synthesis of steroidal derivatives[4], some novel steroidal 4′-acylam...
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It is reported that introduction of aromatic group into steroids has led to new physiological activities[1-3]. As continuation of our study on the synthesis of steroidal derivatives[4], some novel steroidal 4′-acylaminobenzylidene analogues(6a-v) derived from progesterone(1) were prepared by a facile aminoacylation between the corresponding 4′-aminobenzylidene derivative 4 and various acyl chloride. Their cytotoxicity against brine shrimp(Artemia salina) and two human cancer cell lines(HeL a and MCF-7) were investigated. It was found that introduction of benzylidene groups at 21-position of pregn-1,4-diene-3,20-dione(2) was favorable for the cytotoxicity and the nature of acylamino moiety and their conformation in the benzylidene structure had a significant influence on cytotoxic activity.
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