RNA 3D structure and stability is essential for the biological functions of RNAs,and the ion condition is critical for RNA 3D structure and stability due to the polyanionic ***,there is still lack of a unified model f...
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RNA 3D structure and stability is essential for the biological functions of RNAs,and the ion condition is critical for RNA 3D structure and stability due to the polyanionic ***,there is still lack of a unified model for predicting RNA3D structure,stability and salt *** the work,we proposed a coarse-grained model for predicting 3D structure and stability of small RNAs,including RNA
＜正＞Self-assembly processes play a key role in the fabrication of functional nano-structures with widespread application in drug delivery and *** addition to the thermodynamics,the kinetics of the self-assembled nan...
＜正＞Self-assembly processes play a key role in the fabrication of functional nano-structures with widespread application in drug delivery and *** addition to the thermodynamics,the kinetics of the self-assembled nano-structures also play an important role in determining the formed ***,as the self-assembly process is often highly heterogeneous,systematic elucidation of the dominant kinetic pathways of self-assembly is
由于在选择性溶剂中能够形成胶束,两亲性嵌段共聚物受到了人们的广泛关注。两亲性嵌段共聚物的自组装表现出独特的性能,如对pH和温度响应,因此在很多领域具有潜在的应用前景。更好地理解胶束形成过程受环境因素的影响(比如浓度和温度)对于相关应用有重要意义。在两亲性对称三嵌段嵌段共聚物(中间为疏水嵌段)溶液体系中,类似于胶束化,单体/胶束转变可以细分为三阶段:第一阶段,在临界胶束温度(与单体间输水作用χ的临界值χc成反比)以下,聚合物以单体形式存在;第二阶段,胶束开始出现,随着温度的升高胶束聚集程度和胶束总体积显著增加,当胶束总体积趋于不变时标志着第二阶段的结束;第三阶段,胶束的聚集程度随温度降低进一步增加,直到趋于不变。研究发现,在温度降低过程中,两亲性三嵌段嵌段共聚物的聚集与破碎和融合机制(mechanism of fragmentation and fusion)有关,且在高浓度体系中小聚集体(submicelles)破碎为大小明显不同的聚集体参与胶束形成。上述结果有助于更好地理解两亲性嵌段共聚物在平衡态下的聚集过程。
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