Mitofusins are dynamin-related GTPases essential for mitochondrial *** are embedded in the mitochondrial outer membrane(OMM)and thought to fuse adjacent mitochondria via concerted oligomerization and GTP ***,the molec...
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Mitofusins are dynamin-related GTPases essential for mitochondrial *** are embedded in the mitochondrial outer membrane(OMM)and thought to fuse adjacent mitochondria via concerted oligomerization and GTP ***,the molecular mechanisms of mitofusin-mediated OMM fusion are still *** determined crystal structures of engineered
Chromatin remodelers,including Snf2,ISWI,Chd1 and Swr1 subfamilies proteins,control a myriad of nucleic acid transactions by sliding,removing and reconstructing nucleosomes in eukaryotic *** share two Rec A-like core ...
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Chromatin remodelers,including Snf2,ISWI,Chd1 and Swr1 subfamilies proteins,control a myriad of nucleic acid transactions by sliding,removing and reconstructing nucleosomes in eukaryotic *** share two Rec A-like core domains,which couple ATP hydrolysis and DNA translocation to chromatin *** activity of the catalytic core is regulated by different
Dihydrofolate reductase(DHFR)catalyzes the NADPH-dependent reduction of dihydrofolate(DHF)to tetrahydrofolate(THF).The first step in the mechanism involves proton donation to the N5 atom of *** inability to determine ...
Dihydrofolate reductase(DHFR)catalyzes the NADPH-dependent reduction of dihydrofolate(DHF)to tetrahydrofolate(THF).The first step in the mechanism involves proton donation to the N5 atom of *** inability to determine the protonation states of active site residues and substrate has led to a lack of consensus regarding the catalytic mechanism *** resolve this
Surface treatment by oxidizing the plates is a modification of the crystallization plates for protein crystallization screening to promote protein crystallization ***,further experiments proved that the amount of oxid...
Surface treatment by oxidizing the plates is a modification of the crystallization plates for protein crystallization screening to promote protein crystallization ***,further experiments proved that the amount of oxidants and treatment process are necessary for the effect of surface treatment that lead to the consequence of protein crystallization *** order to
Ethylene is an important *** its diverse functions,ethylene promotes the ripening of fruits and senescence of flowers thereby reducing their shelf lives.A specific ethylene biosynthesis inhibitor would help decrease p...
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Ethylene is an important *** its diverse functions,ethylene promotes the ripening of fruits and senescence of flowers thereby reducing their shelf lives.A specific ethylene biosynthesis inhibitor would help decrease postharvest loss.1-Aminocyclopropatie-1-carboxylate(ACC)oxidase(ACO)catalyzed the last step in the ethylene biosynthesis process.
The 2-carboxy-6-hydroxyoctahydroindole(Choi)moiety is an essential residue for the antithrombotic activity of aeruginosins,which are a class of cyanobacterial derived bioactive linear *** biosynthetic pathway of Choi ...
The 2-carboxy-6-hydroxyoctahydroindole(Choi)moiety is an essential residue for the antithrombotic activity of aeruginosins,which are a class of cyanobacterial derived bioactive linear *** biosynthetic pathway of Choi moiety has not been *** F is a putative reductase,which was indicated to be involved in the biosynthesis of Choi ***,
Antibiotic resistance is becoming one of the most catastrophic threats to human health worldwide and this problem is particularly acute in China because of antibiotic *** to Antimicrobial Resistance Global Report(WHO,...
Antibiotic resistance is becoming one of the most catastrophic threats to human health worldwide and this problem is particularly acute in China because of antibiotic *** to Antimicrobial Resistance Global Report(WHO,2014),five of the top seven most prevalent drug-resistant bacterial strains are *** uniqueness of Gram-negative bacteria lies in
Angiotensin II type 1 receptor(AT1R)is a G protein-coupled receptor that serves as a primary regulator for blood pressure *** several anti-hypertensive drugs have been developed as AT1R blockers(ARBs),the structural b...
Angiotensin II type 1 receptor(AT1R)is a G protein-coupled receptor that serves as a primary regulator for blood pressure *** several anti-hypertensive drugs have been developed as AT1R blockers(ARBs),the structural basis for AT1R ligand-binding and regulation has remained elusive,mostly due to the difficulties of growing high quality crystals for structure
X-ray Crystallography is commonly used to study the drug-protein interactions,which not only reveals the drug’s functional mechanism but also provides the clues for pharmaceutical *** proteases have been proved as th...
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X-ray Crystallography is commonly used to study the drug-protein interactions,which not only reveals the drug’s functional mechanism but also provides the clues for pharmaceutical *** proteases have been proved as the therapeutic targets of many important ***
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