Cannabinoid receptor 1（CB）is the principal target of D9-tetrahydrocannabinol（THC）,a psychoactive chemical from Cannabis sativa with a wide range of therapeutic applications and a long history of recreational ***1 ...
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Cannabinoid receptor 1（CB）is the principal target of D9-tetrahydrocannabinol（THC）,a psychoactive chemical from Cannabis sativa with a wide range of therapeutic applications and a long history of recreational ***1 is activated by endocannabinoids and is a promising
Nuclear receptors are essential regulators in the higher eukaryotic *** multi-functional transcription factors are typically regulated by physiological ligands,such as *** for those so-called orphan nuclear receptors,...
Nuclear receptors are essential regulators in the higher eukaryotic *** multi-functional transcription factors are typically regulated by physiological ligands,such as *** for those so-called orphan nuclear receptors,not only there is no physiological ligands identified up to date,their pockets for binding the ligands were non-existent.A better understanding on the physiological roles of orphan nuclear receptors would be attained by deciphering the molecular
The successful crystallisation of proteins is important because their molecular three dimensional structures can be obtained through X-ray diffraction when in their crystalline form[1].Investigation of the crystallisa...
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The successful crystallisation of proteins is important because their molecular three dimensional structures can be obtained through X-ray diffraction when in their crystalline form[1].Investigation of the crystallisation process is beneficial for this *** have reported that protein crystallisation is sensitive to audible sound,which is commonly present but is often ignored.
Caerulomycin A(CRM A)belongs to a family of natural products containing a 2,2’-bipyridyl ring core structure,and is currently under development as a potent novel immunosuppressive *** aminotransferase Crm G was confi...
Caerulomycin A(CRM A)belongs to a family of natural products containing a 2,2’-bipyridyl ring core structure,and is currently under development as a potent novel immunosuppressive *** aminotransferase Crm G was confirmed to catalyze a key transamination reaction to convert an aldehyde group to an amino group in CRM A biosynthetic pathway,preferring L-glutamate and
In humans,GPCRs signal in response to a diverse array of stimuli including light molecules,hormones,and lipids,where these signals affect downstream cascades to impact both health and disease ***,despite their importa...
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In humans,GPCRs signal in response to a diverse array of stimuli including light molecules,hormones,and lipids,where these signals affect downstream cascades to impact both health and disease ***,despite their importance as therapeutic targets,detailed molecular structures of only0 unique GPCRs have been determined to date.A key challenge to their structure
Mycobacterium tuberculosis(Mtb),the etiological agent of human tuberculosis,caused about 1.7 milliin deaths *** has compact and impermeable cell envelop which can protect itself from chemotherapeutic *** genome encode...
Mycobacterium tuberculosis(Mtb),the etiological agent of human tuberculosis,caused about 1.7 milliin deaths *** has compact and impermeable cell envelop which can protect itself from chemotherapeutic *** genome encodes five unique secretion systems,be named after ESX-1 to ESX-5,which involved in invasion of host ***-1 is functioned in
Modern microfocus X-ray sources define the state-of-the-art for most applications in X-ray *** sources are usually combined with multilayer X-ray mirrors which are excellent X-ray optical devices for beam shaping and ...
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Modern microfocus X-ray sources define the state-of-the-art for most applications in X-ray *** sources are usually combined with multilayer X-ray mirrors which are excellent X-ray optical devices for beam shaping and preserving the brightness of the *** performance of the newest generation comes close to the performance of modern microfocus
Turnover of focal adhesions allows cell retraction,which is essential for cell *** mammalian spectraplakin protein,ACF7(Actin-Crosslinking Factor 7),promotes focal adhesion dynamics by targeting of microtubule plus en...
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Turnover of focal adhesions allows cell retraction,which is essential for cell *** mammalian spectraplakin protein,ACF7(Actin-Crosslinking Factor 7),promotes focal adhesion dynamics by targeting of microtubule plus ends towards focal ***,it remains unclear how the activity of ACF7 is regulated spatiotemporally to achieve focal
Jasmonate(JA)is an essential plant hormone that plays important roles in the regulation of plant growth,adjustment against environmental stresses,*** the JA signaling response pathway,the core transcription factors(TF...
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Jasmonate(JA)is an essential plant hormone that plays important roles in the regulation of plant growth,adjustment against environmental stresses,*** the JA signaling response pathway,the core transcription factors(TFs)are a class of basic helix-loop-helix(b HLH)proteins,so-called MYC proteins,especially *** report the 2.7?crystal structure of the MYC2 b HLH
Human cytomegalovirus(h CMV)immediate early 1(IE1)protein associates with condensed chromatin of the host cell during *** have determined the structure of the chromatin-tethering domain(CTD)of IE1 bound to the nucleos...
Human cytomegalovirus(h CMV)immediate early 1(IE1)protein associates with condensed chromatin of the host cell during *** have determined the structure of the chromatin-tethering domain(CTD)of IE1 bound to the nucleosome core particle,and discovered that IE1-CTD specifically interacts with the H2A-H2B acidic patch and impairs the compaction of
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