Jasmonate(JA)is an essential plant hormone that plays important roles in the regulation of plant growth,adjustment against environmental stresses,*** the JA signaling response pathway,the core transcription factors(TF...
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Jasmonate(JA)is an essential plant hormone that plays important roles in the regulation of plant growth,adjustment against environmental stresses,*** the JA signaling response pathway,the core transcription factors(TFs)are a class of basic helix-loop-helix(b HLH)proteins,so-called MYC proteins,especially *** report the 2.7?crystal structure of the MYC2 b HLH
Human cytomegalovirus(h CMV)immediate early 1(IE1)protein associates with condensed chromatin of the host cell during *** have determined the structure of the chromatin-tethering domain(CTD)of IE1 bound to the nucleos...
Human cytomegalovirus(h CMV)immediate early 1(IE1)protein associates with condensed chromatin of the host cell during *** have determined the structure of the chromatin-tethering domain(CTD)of IE1 bound to the nucleosome core particle,and discovered that IE1-CTD specifically interacts with the H2A-H2B acidic patch and impairs the compaction of
Release of Ca from sarcoplasma/endoplasma reticulum（SR/ER）is a key step during the intracellular Ca-handling processes,and underlies various fundamental cellular *** Intracellular Cation（TRIC）channels provide coun...
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Release of Ca from sarcoplasma/endoplasma reticulum（SR/ER）is a key step during the intracellular Ca-handling processes,and underlies various fundamental cellular *** Intracellular Cation（TRIC）channels provide counteracting ionic flux so as to support the release of Ca from SR/ER lumen through ryanodine receptor（RyR）or inositol triphosphate
Equine infectious anemia virus(EIAV)has a life cycle similar to other lentiviruses,including *** glycoprotein gp45,analogous to gp41 in HIV,mediates membrane fusion during EIAV infection.A Val/Ile505 to Thr mutation(c...
Equine infectious anemia virus(EIAV)has a life cycle similar to other lentiviruses,including *** glycoprotein gp45,analogous to gp41 in HIV,mediates membrane fusion during EIAV infection.A Val/Ile505 to Thr mutation(corresponding to Q562 in HIV)in EIAV within gp45 is highly correlated with the vaccine strain,used successfully in equine *** crystal
Modern microfocus X-ray sources define the state-of-the-art for a broad spectrum of applications in home laboratories,such as protein and small molecule crystallography,and small-angle *** sources are combined with mu...
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Modern microfocus X-ray sources define the state-of-the-art for a broad spectrum of applications in home laboratories,such as protein and small molecule crystallography,and small-angle *** sources are combined with multilayer Montel optics to image the source spot onto the *** optics provide a 2D parallel or 2D focused monochromatic X-ray beam,magnified to a suitable size.
STAT6 participates in classical IL-4/IL-13 signaling and STING-mediated antiviral innate immune *** in STAT6-mediated signaling are linked to development of asthma and diseases of the immune *** addition,STAT6 remains...
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STAT6 participates in classical IL-4/IL-13 signaling and STING-mediated antiviral innate immune *** in STAT6-mediated signaling are linked to development of asthma and diseases of the immune *** addition,STAT6 remains constitutively active in multiple
Protein amyloid aggregation is associated with a variety of human devastating diseases such as Alzheimer’s,Parkinson’s and prion disease1,***,several RNA binding proteins including TDP43,FUS and hn RNPA1 were found ...
Protein amyloid aggregation is associated with a variety of human devastating diseases such as Alzheimer’s,Parkinson’s and prion disease1,***,several RNA binding proteins including TDP43,FUS and hn RNPA1 were found to form reversible stress granules under physiological condition,but irreversible amyloid aggregation in pathological *** this study,by using
Assembly of the spliceosomal small nuclear ribonucleoparticle(sn RNP)core requires the participation of the multisubunit SMN complex,which contains SMN and several Gemin *** SMN and Gemin2 subunits directly bind Sm pr...
Assembly of the spliceosomal small nuclear ribonucleoparticle(sn RNP)core requires the participation of the multisubunit SMN complex,which contains SMN and several Gemin *** SMN and Gemin2 subunits directly bind Sm proteins,and Gemin5 is required for sn RNP biogenesis and has been implicated in sn RNA *** RNA sequence required for sn RNP
Loading of 53BP1 and RAP80 at DNA double-strand breaks(DSBs)drives cell cycle checkpoint activation but is counterproductive to high-fidelity DNA ***169 maintains the balance by limiting the deposition of DNA damage m...
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Loading of 53BP1 and RAP80 at DNA double-strand breaks(DSBs)drives cell cycle checkpoint activation but is counterproductive to high-fidelity DNA ***169 maintains the balance by limiting the deposition of DNA damage mediator proteins at the damaged *** report here that this is accomplished,in part,by a predicted NLS that not only shuttles
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