Applications of two-dimensional X-ray diffraction for pharmaceutical research and discovery have dramatically increased since the first high-throughput XRD screening system was introduced in *** has been well recogniz...
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Applications of two-dimensional X-ray diffraction for pharmaceutical research and discovery have dramatically increased since the first high-throughput XRD screening system was introduced in *** has been well recognized that two-dimensional x-ray diffraction is ideal for analyzing samples of limited quantity,which is a typical case for pharmaceutical samples, with better data quality and fast data collection.A two-dimensional diffraction pattern contains information for phase identification,polymorphous structures,crystallinity,particle size and distribution,phase transformation,melting point,and preferred *** one or group of these parameters can be used as criteria for high-throughput screening.
＜正＞Efforts are being made to establish a platform for structural studies in Xiamen *** first group in the discipline is up and running with focus on structural and molecular *** the near future,two additional group...
＜正＞Efforts are being made to establish a platform for structural studies in Xiamen *** first group in the discipline is up and running with focus on structural and molecular *** the near future,two additional groups are set to join Xiamen University with research interests in transcription and nuclear receptors. We exploit the structural knowledge derived from the X-ray crystallography and cryo electron microscopy for the development of icosahedral viruses,especially a plant Cowpea mosaic virus（CpMV）,as the substrates for nano-chemisty *** capsid of CpMV,a 30hm particle in icosahedral symmetry,is associated with many properties ideal for nano-applications,which include high yield,high stability to heat and organic solvents,and a convenient infectious clone system.
多种种属的衣原体是能导致人类感染致病的病原体。人体感染衣原体后,产生特异性的免疫,但是这种免疫力较弱,持续时间短暂,容易造成持续,反复感染,这是衣原体导致人类疾病的主要原因(Beatty et al.)。衣原体能够通过抑制宿主主要组织相...
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多种种属的衣原体是能导致人类感染致病的病原体。人体感染衣原体后,产生特异性的免疫,但是这种免疫力较弱,持续时间短暂,容易造成持续,反复感染,这是衣原体导致人类疾病的主要原因(Beatty et al.)。衣原体能够通过抑制宿主主要组织相容性复合物(MHC)Ⅰ类和Ⅱ类抗原的表达从而逃脱T淋巴细胞的免疫识另lJ(Zhong et al.);抑制宿主受感染细胞凋亡是衣原体成功生存和繁殖所采用的另一个策略(Fan et al.)。衣原体蛋白酶(体)样活性因子CPAF是一功能保守的分子,它在所有种的衣原体感染宿主后都有表达,并显示出相似的蛋白酶活性。现在发现其对降解宿主主要组织相容性复合物(MHC)的转录因子RFX5和上游刺激因子USF-1不仅是足够的,而且是必须的:同时已经证明衣原体通过降解BH3-only前凋亡蛋白来抑制受感染宿主细胞的凋亡,研究发现CPAF能降解广谱的BH3-only前凋亡
The PX scanner is a umque instrument from Oxford Diffraction enabling the collection of X-ray data from protein crystals,in-situ,in the crystallisation *** PX Scanner addresses the bottleneck in high-throughput crysta...
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The PX scanner is a umque instrument from Oxford Diffraction enabling the collection of X-ray data from protein crystals,in-situ,in the crystallisation *** PX Scanner addresses the bottleneck in high-throughput crystallisation allowing a quantitative evaluation of the diffraction properties of crystals without needing to manually extract crystals from the crystallisation plate. Coupling an optical imaging system with a powerful,high brilliance Cu X-ray source,CCD detector and intuitive user software provides an essential laboratory resource for all researchers involved in complex biological crystallography projects.
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