SHENMAI injection(SMI) is a kind of herbal injection widely used in China derived from SHENMAI *** are the major components in *** order to monitor the exposure level of SMI during long-term treatment,a 6-month toxico...
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SHENMAI injection(SMI) is a kind of herbal injection widely used in China derived from SHENMAI *** are the major components in *** order to monitor the exposure level of SMI during long-term treatment,a 6-month toxicokinetic experiment was performed.24 beagle dogs were dived into four groups:Control Group(0.9%NaCl solution;n = 6),Low-dosage Group(2 g/kg;n = 6),Medium-dosage Group(6 g/kg;n = 6) and High-dosage Group(20 g/kg;n = 6).Vehicle and SMI were *** injected everyday for 180 continuous days
Unavoidable side effects of chemotherapy drug,used in oral squamous cell carcinoma(OSCC), including 5-fluorouracil(5FU) and methotrexate(MTX),is still a burden issue *** present study has been demonstrated a simple an...
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Unavoidable side effects of chemotherapy drug,used in oral squamous cell carcinoma(OSCC), including 5-fluorouracil(5FU) and methotrexate(MTX),is still a burden issue *** present study has been demonstrated a simple and effective method for synthesizing 5FU-conjugated gold nanoparticles(5FU-AuNPs) to attenuate drug toxicity in normal cells,and directly target OSCC cells,in which to avoid off-target *** the basis of physical properties, Fourier transform infrared spectroscopy(FT-IR),UV-vis absorption spectroscopy(UV-vis),energy dispersive X-ray fluorescence spectrometry(EDX),and transmission electron microscopy(TEM) were utilized to characterize 5FU-AuNPs,and defined the optimal size approximately 20 nm and shaped in spherical *** thus comprehensively studied the effect of 5FU-AuNP in vitro. 5FU-AuNP showed identical effective IC50 value in cancer cell lines,but it showed no toxicity in
Chemoresistance in cancer therapy is an unfavorable factor for *** to current chemotherapeutics available for the management of non-small cell lung cancer（NSCLC） represents one of the most significant barriers to im...
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Chemoresistance in cancer therapy is an unfavorable factor for *** to current chemotherapeutics available for the management of non-small cell lung cancer（NSCLC） represents one of the most significant barriers to improving long-term survival for patients with ***,we have hypothesized that upregulation of the intracellular calcium level([Ca]) may result in the death of chemoresistant lung cancer *** the[Ca]is elevated during endoplasmic reticulum（ER） stress and may induce cell death through autophagy and ***,the aim of this study was to investigate the role of apoptosis and
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