Ricin has long been employed to construct immunotoxins,whose efficacy was often undermined by ***(modification of proteins with polyethylene glycol,PEG)was one of those recently developedapproaches to circumvent immun...
详细信息
Ricin has long been employed to construct immunotoxins,whose efficacy was often undermined by ***(modification of proteins with polyethylene glycol,PEG)was one of those recently developedapproaches to circumvent immunogenicity of legions of ***,pegylation of ricin was found to have barely
Bodinierin, one of the major proteins in the kernels of camphor tree (Cinnamomum Bodinieri), has beenidentified as a novel type Ⅱ ribosome-inactivating protein. Using sepharose-4B column chromatography followedby aci...
详细信息
Bodinierin, one of the major proteins in the kernels of camphor tree (Cinnamomum Bodinieri), has beenidentified as a novel type Ⅱ ribosome-inactivating protein. Using sepharose-4B column chromatography followedby acid precipitation and ammonium sulfate precipitation, bodinierin has been purified to be homogeneous as char-
Ribosome-inactivating proteins(RIPs)possess a highly specific rRNA N-glycosidase activity and are capableof catalytically inactivating *** Ⅱ RIP are built up of two structurally and functionally different polypep-tid...
详细信息
Ribosome-inactivating proteins(RIPs)possess a highly specific rRNA N-glycosidase activity and are capableof catalytically inactivating *** Ⅱ RIP are built up of two structurally and functionally different polypep-tides(A-and B-chain).The A-chain exhibits RNA N-glycosidase activity while B-chain possesses carbohydrate-binding activity as lectin does.
Drug resistance in cancer is a major obstacle to successful chemotherapy. Cancer cells exposed to anti-tumordrugs may be directly induced to express a subset of genes that could confer resistance. KB cells have been u...
详细信息
Drug resistance in cancer is a major obstacle to successful chemotherapy. Cancer cells exposed to anti-tumordrugs may be directly induced to express a subset of genes that could confer resistance. KB cells have been used forselection of the multidrug resistant (MDR) cell lines. These cells were chosen for the study of MDR because theyare highly sensitive to most chemotherapeutic drugs and they can be cloned with high efficiency and grow rapidly.
Ricin A-chain catalyzes the hydrolysis of the N-glycosidic bond of a conserved adenosine residue at position4324 in the Sarcin/Ricin domain of 28S RNA of rat *** GAGA tetraloop closed by C-G pairs is requiredfor recog...
详细信息
Ricin A-chain catalyzes the hydrolysis of the N-glycosidic bond of a conserved adenosine residue at position4324 in the Sarcin/Ricin domain of 28S RNA of rat *** GAGA tetraloop closed by C-G pairs is requiredfor recognition of the cleavage site on 28S ribosomal RNA by ricin *** this study,ricin A-chain(reduced
暂无评论