Energy homeostasis is strictly regulated by the complex systems at various levels in *** dysregulation of energy homeostasis results in a series of metabolic diseases,such as obesity,diabetes,nonalcoholic fatty liver ...
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Energy homeostasis is strictly regulated by the complex systems at various levels in *** dysregulation of energy homeostasis results in a series of metabolic diseases,such as obesity,diabetes,nonalcoholic fatty liver disease,cardiovascular disease and *** the mechanisms that underlie dysregulated energy balance remain elusive,signaling cross-talks between environmental cues and metabolic flux are known to contribute to energy *** we show how the CREB coactivator CRTC2 as a signaling hub integrates the different stimuli and orchestrates gulcose and lipid metabolism,
Gastrointestinal stromal tumor(GIST)is the most common mesenchymal tumors in the ***-of-function mutation in KIT or PDGFRA results in constitutive activation of theprotein tyrosine kinase and its downstream signaling ...
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Gastrointestinal stromal tumor(GIST)is the most common mesenchymal tumors in the ***-of-function mutation in KIT or PDGFRA results in constitutive activation of theprotein tyrosine kinase and its downstream signaling pathways in *** KIT orPDGFRA tyrosine kinase mutations are compelling therapeutic targets in GISTs,and theKIT/
Obesity represents the accumulation of excessive total body fat and is the result of increased adipocyte numbers and *** droplets are dynamic subcellular organelles whose growth is closely linked to obesity and hepati...
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Obesity represents the accumulation of excessive total body fat and is the result of increased adipocyte numbers and *** droplets are dynamic subcellular organelles whose growth is closely linked to obesity and hepatic *** have shown that CIDE family proteins consisting Cidea,Cideb and Fsp27(Cidec)are important regulators of obesity development as animals with their deficiency are resistant to diet-induced obesity and insulin *** proteins are localized to lipid droplets(LD),and control lipid metabolism in adipocytes and hepatocytes through regulating lipolysis,lipid storage and *** recent analyses suggest that CIDE family proteins are highly enriched at LD-LD contact sites(LDCS)
One of the emerging hallmarks of cancer is aerobic glycolysis,or Warburg Effect,a phenomenon dated back to more than 80 years ago when Otto Warburg described his seminal discovery that cancer cells rely heavily on gly...
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One of the emerging hallmarks of cancer is aerobic glycolysis,or Warburg Effect,a phenomenon dated back to more than 80 years ago when Otto Warburg described his seminal discovery that cancer cells rely heavily on glycolysis for energy sources even with ambient oxygen *** from glucose metabolism,recent years have seen new evidence revealing the reprogramming of glutamine and lipid metabolism during tumor growth in vitro and in vivo.I will present our recent results demonstrating that oncogenic cMyc and HIF1 are critical for reprogramming of glutamine and lipid metabolism in cancer cells.
Humans get cholesterol through de novo synthesis and intestinal *** Pick C1 Like 1(NPC1L1)is a polytopic transmembrane protein responsible for intestinal cholesterol *** have shown that NPC1L1 mediates cholesterol upt...
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Humans get cholesterol through de novo synthesis and intestinal *** Pick C1 Like 1(NPC1L1)is a polytopic transmembrane protein responsible for intestinal cholesterol *** have shown that NPC1L1 mediates cholesterol uptake via vesicular *** mechanism of sterolstimulated NPC1L1 internalization is still ***,we identified an endocytic peptide signal,YVNXXF(where X stands for any amino acid),in the cytoplasmic C-terminal tail of *** binding on the N-terminal domain of NPC1L1 released the YVNXXF-containing region of NPC1L1
The removal of the low-fidelity-synthesized short RNA-DNA primer sequence from each Okazaki fragment is essential for completing the lagging strand DNA synthesis and maintaining genomic *** defective DNA replication i...
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The removal of the low-fidelity-synthesized short RNA-DNA primer sequence from each Okazaki fragment is essential for completing the lagging strand DNA synthesis and maintaining genomic *** defective DNA replication in dna2ts or fen1-cells and the preference of Dna2 and Fen1 to cleave flap DNA
Mammalian development begins with a single cell resulted from the fertilization of a sperm and an *** early embryonic genome undergoes profound epigenetic reprogramming to prepare for *** biological significance and m...
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Mammalian development begins with a single cell resulted from the fertilization of a sperm and an *** early embryonic genome undergoes profound epigenetic reprogramming to prepare for *** biological significance and mechanisms of epigenetic reprogramming are poorly *** find that 5-methylcytosine(5mC),the most abundant type of base modification in DNA,is oxidized to5-hydroxymethylcytosine(5hmC)as well as 5-carboxymethylcytosine(5caC)in mouse *** vitro,the Tet family of dioxygenases oxidize 5mC to 5caC under physiologically relevant conditions(*** the presence of
Metabolic homeostasis is maintained by various cellular sensors,including the master kinases AMPK(AMP-activated protein kinase)and *** response to low energy status,AMPK is activated to enhance catabolic activities wi...
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Metabolic homeostasis is maintained by various cellular sensors,including the master kinases AMPK(AMP-activated protein kinase)and *** response to low energy status,AMPK is activated to enhance catabolic activities with concurrent inhibition of anabolic processes such as fatty acid *** contrast,mTORC1 is activated when nutrients and growth factors are *** have recently discovered the mechanism by which AMP,as a low energy-charge signal,can autonomously initiate the assembly of an activating complex for AMPK in response to *** binding causes a higher affinity of AMPK for the scaffold protein AXIN that also binds to LKB1,thereby promoting phosphorylation and activation of *** recently,we found most surprisingly that the late
DNA methylation plays an important role in cell proliferation, differentiation and individualdevelopment. It can be found in plenty of studies that aberrant methylation of DNA isclosely related with tumor. Although tw...
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DNA methylation plays an important role in cell proliferation, differentiation and individualdevelopment. It can be found in plenty of studies that aberrant methylation of DNA isclosely related with tumor. Although two chemical drugs are already applied to clinical,they cannot lead to a very good effect because of single component working, big sideeffectand easy to produce drug resistance. So it makes great clinical significance on developingand studying DNA demethylation traditional Chinese medicines. DNA demethylationtraditional Chinese medicines are divided into several types according to Chinese medicinein this article. The different targets of various kinds of traditional Chinese medicines to different tumors is also summarized. It makes certain significance on finding new anti-tumormedicines.
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