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检索条件"任意字段=中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议"

共 533 条记录，以下是101-110 订阅

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Dissecting the pathway of intestinal cholesterol absorption

Dissecting the pathway of intestinal cholesterol absorption

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Baoliang Song Wuhan University

Humans get cholesterol through de novo synthesis and intestinal *** Pick C1 Like 1(NPC1L1)is a polytopic transmembrane protein responsible for intestinal cholesterol *** have shown that NPC1L1 mediates cholesterol uptake via vesicular *** mechanism of sterolstimulated NPC1L1 internalization is still ***,we identified an endocytic peptide signal,YVNXXF(where X stands for any amino acid),in the cytoplasmic C-terminal tail of *** binding on the N-terminal domain of NPC1L1 released the YVNXXF-containing region of NPC1L1

关键词： Dissecting the pathway of intestinal cholesterol absorption NPC

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The changes of telomere length of the Culture Human Lymphocytes

The changes of telomere length of the Culture Human Lymphocy...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： ruifeng zhang yuefeng guo 中国辐射防护研究院

Objective To investigate the effect of 12C heavy ion irradiation on telomerelength in culture human *** Culture human lymphocyte line Peng-EBVwere exposed to 12C heavy ion at the irradiation doses of 0.1 Gy, 0.5 Gy, 1... 详细信息

关键词： Telomere length 12C Fluorescence quantitative PCR

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Direct visualization of flap structures and the requirement of Dna2 and Fen1 to remove the RNA-DNA primer sequences from Okazaki fragments

Direct visualization of flap structures and the requirement ...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Bochao Liu Jiazhi Hu Jingna Wang Daochun Kong The College of Life Sciences The National Laboratory of Protein and Plant Gene researchPeking-Tsinghua Center for Life Sciences Peking University

The removal of the low-fidelity-synthesized short RNA-DNA primer sequence from each Okazaki fragment is essential for completing the lagging strand DNA synthesis and maintaining genomic *** defective DNA replication i... 详细信息

关键词： Direct visualization of flap structures and the requirement of Dna2 and Fen1 to remove the RNA-DNA primer sequences from Okazaki fragments DNA RNA

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Mechanistic insights into mitofusin-mediated membrane fusion

Mechanistic insights into mitofusin-mediated membrane fusion

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Xiaoyu Hu Xiaofang Huang Xiaoting Wang Jing Wang Ying Wang Yushan Zhu Quan Chen Junjie Hu Department of Genetics and Cell Biology College of Life Sciences Nankai University and Tianjin Key Laboratory of Protein Sciences The State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Sciences National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences

In eukaryotic cells,mitochondria constantly divide and fuse to maintain proper *** fusion of the outer mitochondrial membranes requires the mitofusin(MFN)proteins,a family of dynamin-like *** is anchored in the membrane by a hairpin of transmembrane(TM)segments,exposing both the N-terminal GTPase domain and the C-terminal tail(CT)to the *** arrangement is very similar to that of the

关键词： MFN Mechanistic insights into mitofusin-mediated membrane fusion

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Structural insights into the molecular function and glycosylation of the serine-rich repeat glycoproteins

Structural insights into the molecular function and glycosyl...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Yong-Liang Jiang Yi-Hu Yang Wei-Wei Shi Rong-Li Zhao Yuxing Chen Cong-Zhao Zhou Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences University of Science and Technology of China

The serine-rich repeat glycoproteins(SRRPs)that exclusively exist in Gram-positive bacteria are a large family of surface adhesins,which are important for bacterial adhesion,immune evasion,colonization,biofilm formation and virulence(1).SRRPs typically consist of a signal peptide at the N-terminus,a short SRR(SRR1),a ligand-binding region(BR)followed by a much longer SRR(SRR2),and a C-terminal LPXTG motif anchoring to the cell *** BRs of SRRPs from different pathogenic bacteria have

关键词： Structural insights into the molecular function and glycosylation of the serine-rich repeat glycoproteins

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Targeted disruption of γ-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth

Targeted disruption of γ-arrestin 2-mediated signaling path...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：孙金鹏 Jonathan Kotula Jeff Kovac 山东大学 Duke University Duke university

β-arrestins,ubiquitous cellular scaffolding proteins that act as signaling mediators of numerouscritical cellular pathways,are attractive therapeutic targets because they promotetumorigenesis in several tumor ***,targeting scaffolding proteins with traditionalsmall molecule drugs has been *** ofβ-arrestin 2 with a novelaptamer impedes multiple oncogenic signaling pathways ***,deliveryof theβ-arrestin 2-targeting aptamer into leukemia cells through coupling to a recentlydescribed cancer cell-specific delivery aptamer,inhibits multipleβ-arrestinmediatedsignaling pathways known to be required for chronic myelogenous leukemia(CML)diseaseprogression,and impairs tumorigenic growth in CML patient *** ability to targetscaffolding proteins such asβ-arrestin 2 with RNA aptamers may prove beneficial as atherapeutic strategy.

关键词： arrestin leukemia

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Metabolic homeostasis——switch between catabolism and anabolism

Metabolic homeostasis——switch between catabolism and anabo...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Sheng-Cai Lin School of Life Sciences Xiamen University

Metabolic homeostasis is maintained by various cellular sensors,including the master kinases AMPK(AMP-activated protein kinase)and *** response to low energy status,AMPK is activated to enhance catabolic activities with concurrent inhibition of anabolic processes such as fatty acid *** contrast,mTORC1 is activated when nutrients and growth factors are *** have recently discovered the mechanism by which AMP,as a low energy-charge signal,can autonomously initiate the assembly of an activating complex for AMPK in response to *** binding causes a higher affinity of AMPK for the scaffold protein AXIN that also binds to LKB1,thereby promoting phosphorylation and activation of *** recently,we found most surprisingly that the late

关键词： ATPase Metabolic homeostasis switch between catabolism and anabolism

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Progresses on Anti-tumor Traditional Chinese Medicines of DNA Demethylation

Progresses on Anti-tumor Traditional Chinese Medicines of DN...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：张敏江西中医药大学

DNA methylation plays an important role in cell proliferation, differentiation and individualdevelopment. It can be found in plenty of studies that aberrant methylation of DNA isclosely related with tumor. Although two chemical drugs are already applied to clinical,they cannot lead to a very good effect because of single component working, big sideeffectand easy to produce drug resistance. So it makes great clinical significance on developingand studying DNA demethylation traditional Chinese medicines. DNA demethylationtraditional Chinese medicines are divided into several types according to Chinese medicinein this article. The different targets of various kinds of traditional Chinese medicines to different tumors is also summarized. It makes certain significance on finding new anti-tumormedicines.

关键词： DNA demethylation traditional Chinese medicine anti-tumor

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miRNA regulatory circuits of the thymic γδ T cell development

miRNA regulatory circuits of the thymic γδ T cell developm...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Yang Yang Zhang Qian Zhang Yan Jin Shenzhen Institutes of Advanced Technology CAS

Innate-like γδ T cells function in the early phase of immune responses. Although the transcriptionalregulation of messenger RNAs of the γδ T cells has been elucidated by ImmunologicalGenome Project(ImmGen), the microRNAs(miRNA) controlled post- transcriptionalregulations are barely understood. In the present study, two emergent γδ thymocytesubsets Vγ3+ and Vγ2+ γδ T cells were used as prototypes to systematically analyze themiRNA regulatory circuits of the thymic γδ T cell development. Differential expressedmiRNAs were identified with high throughput sequencing. Further bioinformatic analysisindicated that several miRNAs:mRNA regulatory pairs correlate with the selection, migrationand the production of signature cytokines of γδ T cells.

关键词： gammadelta T cells microRNA development

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Hydrogen peroxide triggers the fibrillization of human superoxide dismutase 1 via oxidative modification of Cys-111

Hydrogen peroxide triggers the fibrillization of human super...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：李成徐文倡刘晓灵陈杰梁毅武汉大学生命科学学院病毒学国家重点实验室

Growing evidence indicates that the fibrillization of human copper,zinc superoxide dismutase(SOD1)could play an important role in the etiology of both familial and sporadic amyotrophic lateral ***1 undergoes oxidative damage by its own reaction product hydrogen ***,it has not been reported so far whether this antioxidant enzyme misfolds and form amyloid fibrils under oxidative

关键词： Hydrogen peroxide triggers the fibrillization of human superoxide dismutase 1 via oxidative modification of Cys-111 SOD

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