Controversial roles of FOXP3 in different cancers have been reported previously, while itsrole in gastric cancer is largely *** we found that FOXP3 is unexpectedly upregulatedin some gastric cancer cells and remains t...
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Controversial roles of FOXP3 in different cancers have been reported previously, while itsrole in gastric cancer is largely *** we found that FOXP3 is unexpectedly upregulatedin some gastric cancer cells and remains the tumor suppressor role in gastriccancer in basal condition.
Objective To investigate the effect of 12C heavy ion irradiation on telomerelength in culture human *** Culture human lymphocyte line Peng-EBVwere exposed to 12C heavy ion at the irradiation doses of 0.1 Gy, 0.5 Gy, 1...
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Objective To investigate the effect of 12C heavy ion irradiation on telomerelength in culture human *** Culture human lymphocyte line Peng-EBVwere exposed to 12C heavy ion at the irradiation doses of 0.1 Gy, 0.5 Gy, 1.0 Gy, 2.0 Gyand the dose rate was 0.3-0.5 Gy/min., respectively.
In eukaryotic cells,mitochondria constantly divide and fuse to maintain proper *** fusion of the outer mitochondrial membranes requires the mitofusin(MFN)proteins,a family of dynamin-like *** is anchored in the membra...
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In eukaryotic cells,mitochondria constantly divide and fuse to maintain proper *** fusion of the outer mitochondrial membranes requires the mitofusin(MFN)proteins,a family of dynamin-like *** is anchored in the membrane by a hairpin of transmembrane(TM)segments,exposing both the N-terminal GTPase domain and the C-terminal tail(CT)to the *** arrangement is very similar to that of the
Hydrogels have strong application prospects for drug delivery,tissue engineering and celltherapy because of their excellent biocompatibility and abundant availability as scaffoldsfor drugs and *** this study,we develo...
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Hydrogels have strong application prospects for drug delivery,tissue engineering and celltherapy because of their excellent biocompatibility and abundant availability as scaffoldsfor drugs and *** this study,we developed a hydrogel formed via Michael addition byusing a recombinant mutant protein incorporated with a bioactive peptide and commercial4-armed-PEGMal,which was able to provide an excellent environment for a three dimensionalcell culture of AD293 *** AD293cells continued to divide and displayed apolyhedron or spindle-shape during the 3-day culture *** type of hydrogel couldbe converted into a homogeneous solution by first treating with trypsinase and then ***,AD293cells could be easily separated from the cell-gel constructs afterbeing cultured for 3 *** work significantly expands the toolbox of recombinant proteinsfor hydrogel formation,and we believe that our hydrogel will be of considerable interestto those working in cell therapy and controlled drug delivery.
Kinases play pivotal roles in virtually all aspects of cellular physiology1. Potentand selective kinase inhibitors are highly desirable, both as tool compounds for dissectingcomplex signaling pathways and as potential...
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Kinases play pivotal roles in virtually all aspects of cellular physiology1. Potentand selective kinase inhibitors are highly desirable, both as tool compounds for dissectingcomplex signaling pathways and as potential therapeutics for treating kinase-related *** there is an urgent need to develop methodologies that will allow for the rapididentification of kinase inhibitors of interest. Compound centric kinome-wide profilingenables rapid discovery of the full range of kinasetargets for a particular scaffold2. Herewe describe the development of potent and selective ERK5 inhibitor3, XMD8-92 and LRRK2 inhibitors4, LRRK2-IN-1, using 'compound-centric' profiling of designed focuskinase-directed library deriving from a pyrimido-diazepine scaffold.
The serine-rich repeat glycoproteins(SRRPs)that exclusively exist in Gram-positive bacteria are a large family of surface adhesins,which are important for bacterial adhesion,immune evasion,colonization,biofilm formati...
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The serine-rich repeat glycoproteins(SRRPs)that exclusively exist in Gram-positive bacteria are a large family of surface adhesins,which are important for bacterial adhesion,immune evasion,colonization,biofilm formation and virulence(1).SRRPs typically consist of a signal peptide at the N-terminus,a short SRR(SRR1),a ligand-binding region(BR)followed by a much longer SRR(SRR2),and a C-terminal LPXTG motif anchoring to the cell *** BRs of SRRPs from different pathogenic bacteria have
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