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检索条件"任意字段=中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议"

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Structural insights into the activation mechanism of the major autolysin LytA

Structural insights into the activation mechanism of the maj...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：成望周丛照 University of Science & Technology of China

LytA is responsible for the autolysis of many Streptococcus species,including pathogenslike ***,*** and ***,it remains unknown howthe enzymatic activity of this major autolysin is *** we report the full-lengthstructure of *** LytA dimer at 2.1 ? *** subunit has an N-terminalamidase domain and a C-terminal choline-binding domain of six choline-binding repeats,which form five canonical and one single-layered choline-binding sites.A putative Yshapedsubstrate-binding groove is proposed to accommodate the three branches ofpneumococcal cell ***-directed mutageneses combined with hydrolytic activity assaysindicate that dimerization and binding to choline are two independent requirementsfor the autolytic activity of *** propose a model in which a choline-dependent foldingprocess leads to a fully active boomerang-like LytA dimer,which conformation allowsthe amidase domain to cleave two lactyl-amide bonds located about 103 ? apart on thepeptidoglycan.

关键词： Streptococcus pneumoniae autolysin

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Determination of Urinary Creatinine by Capillary Zone Electrophoresis

Determination of Urinary Creatinine by Capillary Zone Electr...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Ping-ping Zhang Key Laboratory of Neural and Vascular Biology Department of Biochemistry and Molecular BiologyMinistry of Education Hebei Medical University

Creatinine is the catabolic end product of creatine, being produced in muscle tissues andeliminated in urine. It is a very useful clinical biomarker of renal function and an internalstandard to correct the excretion rate of other biological compounds in a urine sample. Inour previous work, a reliable, convenient and low-cost method for the determination of urinarycreatinine by capillary zone electrophoresis was established. A typical calibration plotfrom 1 mg L-1 to 200 mg L-1(R2 = 0.9978) with a detection limit of 0.15 mg L-1(S/N =3) is achieved. The relative standard deviation was less than 4.2% for peak area and 0.5%for migration time, respectively. The proposed method was successfully applied to the determinationof urinary creatinine.

关键词： creatinine capillary zone electrophoresis

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Targeted disruption of γ-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth

Targeted disruption of γ-arrestin 2-mediated signaling path...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：孙金鹏 Jonathan Kotula Jeff Kovac 山东大学 Duke University Duke university

β-arrestins,ubiquitous cellular scaffolding proteins that act as signaling mediators of numerouscritical cellular pathways,are attractive therapeutic targets because they promotetumorigenesis in several tumor ***,targeting scaffolding proteins with traditionalsmall molecule drugs has been *** ofβ-arrestin 2 with a novelaptamer impedes multiple oncogenic signaling pathways ***,deliveryof theβ-arrestin 2-targeting aptamer into leukemia cells through coupling to a recentlydescribed cancer cell-specific delivery aptamer,inhibits multipleβ-arrestinmediatedsignaling pathways known to be required for chronic myelogenous leukemia(CML)diseaseprogression,and impairs tumorigenic growth in CML patient *** ability to targetscaffolding proteins such asβ-arrestin 2 with RNA aptamers may prove beneficial as atherapeutic strategy.

关键词： arrestin leukemia

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Establish and practice on evaluation system of biochemistry andmolecular biology experiment course

Establish and practice on evaluation system of biochemistry ...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：王丹成都医学院

To adapt to the experimental teaching reform in our school, the paper establishes an evaluationsystem including experience preparation, experience process, comprehensive anddesign of experiments, experience skills and written exam. Among them, the experimentalpreparation assessment of "preview and self-evaluation report" by students preparing andsubmitted. The experience process assessment of students' classroom performance andexperience *** assessment of comprehensive and design experiments evaluationof the overall participation of *** skills assessment consists of two parts of responseand verification of the *** final written examination is composed ofsubjective questions, pays attention to examine student's level of flexible use of knowledgeand ability to solve practical *** evaluation system of promoting student'slearning and teacher's teaching by the exam not only fully arouse student's emphasis onexperiment, and make teachers more objective and real understand students' learningsituation and the teaching effectiveness.

关键词： experimental teaching teaching reform evaluation system

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Targeting mitochondrial glutaminase inhibits non-small cell lung cancer cell growth and migration

Targeting mitochondrial glutaminase inhibits non-small cell ...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Jian-Bin Wang De Kang Tianyu Han Weihua Zhan Yong Li The Institute of Translational Medicine Nanchang University

The importance of altered metabolism in cancer progression is receiving much attention given the suggestions that elevated glutamine metabolism and its role in replenishing citric acid cycle intermediates are essential features of malignant *** this study,we found that non-small cell lung cancer cells showed great dependency on glutamine metabolism,and exhibit higher glutaminase activity than normal human bronchial epithelial cells(HBEs).Treatment of non-small cell lung cancer cells with968,a small molecule inhibitor of glutaminase,or knocking down glutaminase by siRNA inhibited their proliferation,migration and cell *** also found that Glutaminase activity was blocked while treated

关键词： CRL Targeting mitochondrial glutaminase inhibits non-small cell lung cancer cell growth and migration

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Vitamin C enhances tet-mediated 5-methylcytosine oxidation as a cofactor and promotes DNA demethylation in mammals

Vitamin C enhances tet-mediated 5-methylcytosine oxidation a...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Hailin Wang The State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

DNA demethylation remarkably contributes to the dynamics of the epigenetic marker 5-methylcytosine(5mC)in mammals,and is critical for multiple biological processes,including animal cloning,nuclear reprogramming,development,and highly locus-specific regulation of gene *** DNA demethylation can be initiatedby the oxidation of 5-methylcytosine(5mC)and the formation of 5-hydroxymethylcytosine(5hmC),which are catalyzed by Ten Eleven Translocation(Tet)family dioxygenases *** 5hmC can be further oxidized by Tet proteins to form 5-formylcytosine(5fC)and 5-carboxylcytosine(5caC),which can be excised by thymine DNA

关键词： Vitamin C enhances tet-mediated 5-methylcytosine oxidation as a cofactor and promotes DNA demethylation in mammals DNA

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Intracellular signaling modulation by metabolites

Intracellular signaling modulation by metabolites

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Yakun Zhang Feng Li Xiadi He Jianyuan Zhao Wei Xu Shimin Zhao Institutes of Biomedical Sciences Fudan University State Key Laboratory of Biotherapy/ Collaborative Innovation Center for Biotherapy West China Hospital Sichuan University

Many signaling cascades are originated from cell membrane to sense environmental changes and transduce signals into cells in order for cells to make adaption to these ***,how cells sense internal states and integrate internal signals into external signals to make proper changes that meet needs from both internal and external remains largely *** found metabolites are signaling molecules and generate internal signaling by various *** report that cell growth and proliferation are promoted by nutrient-enhanced acetylation of enoyl-CoA hydratase 1(ECHS1),the dual functional enzyme that functions in oxidation of free fatty acids(FFA)and branched chain amino acids(BCAA).

关键词： Intracellular signaling modulation by metabolites

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Pigment epithelium-derived factor inhibits the metastasis of breastcancer via down-regulation of Fibronectin

Pigment epithelium-derived factor inhibits the metastasis of...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：洪宏海中山大学中山医学院生化实验室

Pigment epithelium-derived factor(PEDF) is a multi-functional secreted glycoprotein thathas an important role in neural retina protection and tumor anti-angiogenic activity, butthe effect and mechanism of PEDF on breast cancer metastasis remains unclear. Here weshow that PEDF significantly inhibits breast cancer metastasis in animal experiment and invitro of MDA-MMB-231 cells level. Furthermore, we found that PEDF inhibits the invasionand metastasis of breast cancer is dependent on reducing Fibronectin expression and notassociated with EMT process, whereas adding fibronectin abrogates these effects. In addition,down-regulation of Fibronectin by PEDF is due to the suppression of intracellular p-ERK/p-AKT signaling. Together, these findings indicate that PEDF effectively inhibits breastcancer invasion and metastasis via reducing the expression of fibronectin.

关键词： fibronectin mmp-2

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Scorpion toxin-potassium channel interactions and their applications

Scorpion toxin-potassium channel interactions and their appl...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Yingliang Wu Wuhan University

Facing the interactions between numerous scorpion toxins and many potassium channels,their possible interaction modes and mechanisms are basic scientific *** and experimental techniques,we characterized diverse scorpion toxin-potassium channel *** for scorpion toxins with similar 3D structures containingoneα-helix and one anti-parallelβ-sheet,we found that scorpion toxins adopteddiverse binding interfaces to recognize potassium *** for the potassium channels,their vestibules were also found to present various conformations for scorpion toxin *** on the diverse interactions between scorpion toxins and potassium channels,the novel protein recognition control technique was proposed and validated by theswitch between the binding and non-binding interfaces of scorpion toxin BmP05acting onpotassium *** technique was further used to design Kv1.3 channel-selectivescorpion toxin blockers for the future research and development of peptide drugs treatingT cell-mediated autoimmune diseases.

关键词： scorpion toxins potassium channels

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Active DNA and RNA demethylation in epigenetic regulation

Active DNA and RNA demethylation in epigenetic regulation

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Chuan He Department of Chemistry and Institute for Biophysical Dynamics Howard Hughes Medical InstituteThe University of Chicago 929 East 57th StreetChicago IL 60637 USA

Cytosine methylation(5mC)is a well-established epigenetic mechanism essential for genomic imprinting,X chromosome inactivation,silencing of retrotransposons,and lineage-specific expression of many developmental regulatory *** epigenetic mark is installed and maintained by DNA methyltransfeases(DNMTs),and has been recently shown to be oxidized to 5-hydroxymethylcytosine(5hmC),5-formylcytosine(5fC)and5-carboxylcytosine(5caC)by the Ten-eleven-translocation(TET)family of protein dioxygenases(Figure 1).In humans and mice,5hmC is found in most cell types and tissues,with the abundance ranging from less than 0.1%to 0.4%of all *** contrast,the abundance of 5fC and 5caC is very low to *** have

关键词： Active DNA and RNA demethylation in epigenetic regulation DNA

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