检索结果-内蒙古大学图书馆

您好，读者！请登录

内蒙古大学图书馆

首页
概况
党建
资源
服务
科研支持
- 论文收录引用证明
- 科技查新
知识产权
档案馆
帮助

咨询与建议

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

您的常用邮箱：*

您的手机号码：*

问题描述：

当前已输入0个字，您还可以输入200个字

全部搜索
期刊论文
图书
学位论文
标准
纸本馆藏
外文资源发现
数据库导航
超星发现

高级检索

时间限定

出版年份：

文献类型

图书期刊文献学位论文多媒体

馆藏选择

电子馆藏纸本馆藏

核心期刊

全部期刊 SCI 收录期刊 SSCI 收录期刊 EI 收录期刊 CSCD 收录期刊 CSSCI 收录期刊

语言

中文英文

文献类型

期刊文献图书学位论文标准纸本馆藏

帮助

文字说明：

T=题名（书名、题名），A=作者（责任者），K=主题词，P=出版物名称，PU=出版社名称，O=机构（作者单位、学位授予单位、专利申请人），L=中图分类号，C=学科分类号，U=全部字段，Y=年（出版发行年、学位年度、标准发布年）

检索规则说明：

AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：

范例一：(K=图书馆学 OR K=情报学) AND A=范并思 AND Y=1982-2016
范例二：P=计算机应用与软件 AND (U=C++ OR U=Basic) NOT K=Visual AND Y=2011-2016

分类表

所选分类

>> <<

限定检索结果

文献类型

529 篇 会议
4 篇 期刊文献

馆藏范围

533 篇 电子文献
0 种 纸本馆藏

日期分布

学科分类号

278 篇 医学
- 151 篇 临床医学
- 83 篇 基础医学(可授医学...
- 36 篇 中西医结合
- 28 篇 药学(可授医学、理...
- 21 篇 中药学(可授医学、...
- 2 篇 公共卫生与预防医...
- 2 篇 医学技术（可授医学...
- 1 篇 中医学
248 篇 理学
- 246 篇 生物学
- 2 篇 物理学
- 1 篇 生态学
171 篇 工学
- 140 篇 化学工程与技术
- 25 篇 生物工程
- 2 篇 机械工程
- 2 篇 材料科学与工程（可...
- 2 篇 食品科学与工程（可...
- 1 篇 电子科学与技术（可...
- 1 篇 纺织科学与工程
- 1 篇 轻工技术与工程
- 1 篇 农业工程
- 1 篇 生物医学工程（可授...
- 1 篇 公安技术
71 篇 农学
- 58 篇 作物学
- 9 篇 畜牧学
- 2 篇 水产
- 1 篇 农业资源与环境
- 1 篇 植物保护
13 篇 教育学
- 13 篇 教育学

主题

10 篇 dna
4 篇 会员代表大会
4 篇 中国生物化学与分...
4 篇 学术会议
4 篇 rna
3 篇 国际会议中心
3 篇 领域专家
3 篇 生物化学
3 篇 domain
3 篇 厦门市
3 篇 pbl
2 篇 lncrnas β-thalas...
2 篇 hbv
2 篇 ampk
2 篇 白花丹参
2 篇 高通量测序
2 篇 vsmcs
2 篇 mirnas
2 篇 2型糖尿病
2 篇 sm22α

机构

13 篇 北京大学
10 篇 厦门大学
9 篇 清华大学
8 篇 山东大学
7 篇 复旦大学
7 篇 key laboratory o...
7 篇 peking universit...
7 篇 中国科学技术大学
6 篇 第四军医大学
6 篇 武汉大学
5 篇 江西中医药大学
5 篇 school of life s...
5 篇 institute of bio...
5 篇 department of bi...
5 篇 浙江大学
5 篇 河北医科大学
4 篇 institute of bio...
4 篇 school of pharma...
4 篇 军事医学科学院放...
4 篇 上海交通大学

作者

6 篇 周丛照
6 篇 qun wei
6 篇 youxin jin
6 篇 孙金鹏
5 篇 botao zhao
5 篇 xiaofeng zheng
5 篇 zhongyi cheng
5 篇 detao wang
5 篇 闫永彬
4 篇 zhihua wu
4 篇 jiali wei
4 篇 zhengping xu
4 篇 donghai lin
4 篇 guoqin jin
4 篇 li zhang
4 篇 韩梅
4 篇 陈宇星
4 篇 刘晓灵
4 篇 梁毅
4 篇 zheqi li

语言

470 篇 英文
63 篇 中文

检索条件"任意字段=中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议"

共 533 条记录，以下是141-150 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：田钰茜第四军医大学药学系生物制药学教研室

CD4+CD25+FoxP3+Regulatory T cells(Tregs)play a crucial role in immunological selftoleranceand immune homeostasis,but how this regulation is achieved remains *** our study,we verified ubiquitously expressed transcript(UXT)as a novelregulator of human Treg-cell *** could interact with proline-rich domain in theN-terminus of Foxp3 inside the nucleus of Treg *** and Foxp3 both expressed inTreg cells and the protein expression level changes of UXT altered the suppressive functionand *** of UXT affected the localization stability of Foxp3 inthe nucleus and down-regulated the expression of Foxp3-related *** short,our resultsillustrate that UXT is associated with Foxp3 and it is an important regulator of Tregcells.

关键词： UXT Foxp3 reglutor Immune suppression Regulatory T(Treg) cell

来源：评论

学校读者我要写书评

暂无评论

Purification and characterization of an extracellular chitinase from a newly isolated chitinolyticbacter meiyuanensis SYBC-H1

Purification and characterization of an extracellular chitin...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Zhikui Hao Hangui Wu Meiling Yang Jianjun Chen Xiangru Liao Biopharmaceutical R & D Center Taizhou Vocational & Technical College The Key Laboratory of Industrial B iotechnology Ministry of Education School of Biotechnology Jiangnan University

Chitinase was purified from the bacterium *** SYBC-H1 isolated from the soilsamples collected from Meiyuan *** chitinase was purified by ammonium sulphateprecipitation followed by DEAE-cellulose column and than Sephadex *** waspurified by 10.16 folds with 20.9%*** characterization through SDS-PAGEanalysis showed that it has molecular weight of about 39 *** enzyme kinetics studiesof purified chitinase revealed the following characteristics,Km 6.25 mg/ml and Vmax 9.066U/mg for 4-Nitrophenyl-N-acetyl-α-D-glucopyranoside as a *** optimum chitinaseactivity was observed at 40°*** optimum pH for chitinase is 6.5,with appreciableactivity between 3.5and *** staining show two kinds of chitinase isoenzyme wereproduced.β-mercaptoethanol has worked a lot for the stability of Chitinase.

关键词： Chitinase purification stability β-mercaptoethanol C.Meiyuanensis SYBC-H1

来源：评论

学校读者我要写书评

暂无评论

Identification and characterization of novel serum microRNAcandidates from deep sequencing in cervical cancer patients

Identification and characterization of novel serum microRNAc...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Juan Li Yaping Tian 解放军总医院生化科

Small non-coding microRNAs(miRNAs)are involved in cancer development and progression,and serum profiles of cervical cancer patients may be useful for identifying *** performed deep sequencing on serum pools of cervical cancer patients andhealthy controls with 3 replicates and constructed a small RNA *** used MIREAP topredict novel miRNAs and identified 2 putative novel miRNAs between serum pools of cervicalcancer patients and healthy controls after filtering out pseudo-pre-miRNAs usingTriplet-SVM *** 2 putative novel miRNAs were validated by real time PCR andwere significantly decreased in cervical cancer patients compared with healthy *** novel miRNA had an area under curve(AUC)of 0.921(95%CI:0.883,0.959)with asensitivity of 85.7%and a specificity of 88.2%when discriminating between cervical cancerpatients and healthy *** results suggest that characterizing serum profiles of cervicalcancers by Solexa sequencing may be a good method for identifying novel miRNAsand that the validated novel miRNAs described here may be cervical cancer-associatedbiomarkers.

关键词： microRNA crvical cancer

来源：评论

学校读者我要写书评

暂无评论

Role of ADAMTS1 in adipogenesis

Role of ADAMTS1 in adipogenesis

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：陈素贞 haiyan huang qiqun tang fudan univercity

Formation of adipose tissue is a complex process requiring designation of mesodermalstem cells to a preadipocyte lineage and differentiation of preadipocytes into *** adipose tissue, the ECM is crucial for maintaining the structural integrity of adipocytesand plays a pivotal role in adipogenesis and whole tissue formation. However, the potentialimpact of ECM in adipocyte lineage commitment is still unclear. Here, our studiesshowed that the expression of ECM component ADAMTS1(a new metalloprotease) decreaesdin subcutaneous adipose tissue of obese mice when compared to lean mice. theexpression of ADAMTS1 desreased during the adipocytic lineage commitment as well. Wealso found that miR-181 d might be responsible for ADAMTS1's downregulation duringadipogenesis. Our further studies showed that ADAMTS1 plays an inhibitory role in *** the metalloprotease activity of ADAMTS1, we proposed thatADAMTS1 may contribute to the commitment of preadipocyte by remodelling *** studies will open up new opportunities for the development of drugs forobesity and its metabolic and cardiovascular complications.

关键词： ADAMTS1 ECM adipogenesis miR181d

来源：评论

学校读者我要写书评

暂无评论

Crystal structure of juvenile hormone epoxide hydrolase from Bombyx mori

Crystal structure of juvenile hormone epoxide hydrolase from...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：周康贾宁胡晨江永亮杨捷频陈宇星李胜李卫芳周丛照中国科学技术大学生命科学学院上海生命科学研究院植物生理学和生态学研究所

Juvenile hormone(JH)epoxide hydrolase(JHEH)catalyzes JH degradation to produce juvenilehormone diol and regulates the metamorphosis development of *** wedetermined the 2.6crystal structure of JHEH from Bombyx mori(BmJHEH).The overallstructure of BmJHEH is composed of a coreα/βhydrolase domain,an all-αlid region andan N-terminal anchor *** analyses together with molecular remodeling revealnovel insights of the active-site pocket for JH *** findings increase ourunderstanding of the substrate recognition and catalysis of microsomal epoxide hydrolasesand might help the design of JH-analogue pesticides.

关键词： Bombyx mori juvenile hormone microsomal epoxide hydrolase crystal structure

来源：评论

学校读者我要写书评

暂无评论

Role of ADAMTS1 in adipogenesis

Role of ADAMTS1 in adipogenesis

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Suzhen Chen Haiyan Huang Qiqun Tang Fudan univercity

关键词： ADAMTS1 Adipogenesis ECM remodeling miR-181d

来源：评论

学校读者我要写书评

暂无评论

Glycyrol suppresses collagen-induced arthritis by regulatingautoimmune and inflammatory responses

Glycyrol suppresses collagen-induced arthritis by regulating...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Yanxia Fu Hailing Zhou Shuangyan Wang Qun Wei Department of Biochemistry and Molecular Biology Beijing Normal University Gene engineering and Biotechnology Beijing Key Laboratory

Glycyrol is a natural compound extracted from Glycyrrhiza uralensis, first reported by us tobe a new immunosuppressant. Here, we demonstrate its beneficial effect in collagen-induced arthritis(CIA) in mice, a model for rheumatoid arthritis(RA) in man, and wedocument the underlying mechanisms. Peroral administration of glycyrol significantly reducedclinical scores, alleviated cartilage and bone erosion and reduced levels of serum inflammatorycytokines. Glycyrol also decreased delayed-type hypersensitivity(DTH), improvedcarbon clearance and reduced acetic acid-induced capillary permeability. Furthermore,glycyrol decreased NF B and NFAT transcriptional activities and inhibited IL-2 *** therapeutic effect of glycyrol was associated with down-regulation of bothautoimmune and inflammatory reactions. In addition, we demonstrated that glycyrol hasminimal acute toxicity in mice. Therefore, we propose that glycyrol may hold promise forfuture treatment of RA.

关键词： glycyrol rheumatoid arthritis autoimmune inflammation

来源：评论

学校读者我要写书评

暂无评论

The new Immunosuppressant, isogarcinol, binds directly to itstarget enzyme calcineurin, unlike cyclosporin A and tacrolimus

The new Immunosuppressant, isogarcinol, binds directly to it...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Juren Cen Mengqi Wang Guohua Jiang Yanxia Yin Zhenyi Su Li Tong Jing Luo YipengMa Qun Wei Department of Biochemistry and Molecular Biology Beijing Normal University Gene engineering and Biotechnology Beijing Key Laboratory

Isogarcinol, a bioactive polyisoprenylated benzophenone derivative isolated fromGarcinia mangostana L., has been shown previously to exert a strong inhibitory effect oncalcineurin and is thus a potential oral, low-toxicity immunomodulatory drug. In thepresent study, enzyme kinetic analysis showed that inhibition of calcineurin by isogarcinolwas competitive. Fluorescence spectroscopy indicated that isogarcinol bound to *** titration calorimetry showed that binding was mainly driven by enthalpy,and was exothermic because the enthalpy change exceeded the entropy reduction. The interactionforce is either hydrogen bonding or Van der Waals forces. Fluorescence resonanceenergy transfer and molecular docking experiments indicated that there were twopotential binding sites for isogarcinol in the catalytic domain of calcineurin. In summary,isogarcinol binds directly to calcineurin in vitro, unlike the classical calcineurin inhibitorscyclosporin A and tacrolimus.

关键词： isogarcinol calcineurin isothermal titration calorimetry fluorescences pectroscopy docking

来源：评论

学校读者我要写书评

暂无评论

Anti-Enterovirus 71 Effects of Amphotericin B

Anti-Enterovirus 71 Effects of Amphotericin B

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Fengwen Xu Tingting Liu Xiaoxiao Zhao Fei Guo Institute of Pathogen Biology Chinese Academy of Medical Sciences and Peking Union Medical College

Enterovirus 71(EV71) can cause severe disease and even lead to death in children, and aneffective antiviral drug is currently unavailable. Amphotericin B has been used to treat systemicfungal infections, including Aspergillosis, since the 1950’s, and its clinical formulationsare currently used widely to treat a growing number of such cases. Amphotericin Bwas reported to exhibit antiviral effects against vesicular stomatitis virus, herpes simplexvirus types 1 and 2, and Sindbisvirus. We found that Amphotericin B could inhibit EV71 proliferation and Amphotericin B could block the attachment and entry of EV71 to hostcells to regulate the early stage of EV71 infection. Our results are helpful to understand themechanism for EV71 life cycle and provide a potential for the usage of an approved drugagainst EV71 infection.

关键词： EV71 Amphotericin B

来源：评论

学校读者我要写书评

暂无评论

preparation of DNA G-quadruplex structure specific antibody

preparation of DNA G-quadruplex structure specific antibody

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： yiqiang zhang Xiaoyu Lan Shuang Wang Zhirong Liu Jinyan Shen Meining Li Xingshun Liu Yuehong Zhang Jun Xie Niuliang Cheng Department of Biochemistry and Molecular Biology Shanxi Medical University

Bioinformatics research suggests guanine rich in DNA can be folded into a special kind ofsecondary structure called the G-quadruplex referred to as G4. Its widely exists in the genomepromoter regions(c-myc, c-kit, VEGF, Bcl-2) and the chromosomes which plays an importantrole for cancer gene expression and regulation of telomerase activity. So the cellstructure of G4, in tumor treatment has become a research hotspot in recent years andbeen considered to be important targets for cancer molecular targeted therapy drugs. Thisgroup constructed the DNA G-quadruplex structure specific expression vector and abundantlyexpressed in escherichia coli BL21, then purification and identification this *** antibody can be used to directly observed DNA G-quadruplex structure formation in afluorescence microscope and provide a means for drug screening in G4 stabilizer.

关键词： G-quadruplex antibody

来源：评论

学校读者我要写书评

暂无评论

没有更多数据了...

全选清除本页清除全部题录导出标记到“检索档案”

共54页 << < 11 12 13 14 15 16 17 18 19 20 > >>

检索报告对象比较合并检索0

隐藏清空

合并搜索

回到顶部

执行限定条件

内容：

评分：

请选择保存的检索档案：

请选择收藏分类：

订阅名称：

通借通还

温馨提示：

图书名称：

借书校区：

取书校区：

手机号码：

邮箱地址：

一卡通帐号：

电话和邮箱必须正确填写，我们会与您联系确认。

联系人：

所在院系：

联系邮箱：

联系电话：

内蒙古自治区呼和浩特市赛罕区大学西街235号邮编: 010021

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：