检索结果-内蒙古大学图书馆

您好，读者！请登录

内蒙古大学图书馆

首页
概况
党建
资源
服务
科研支持
- 论文收录引用证明
- 科技查新
知识产权
档案馆
帮助

咨询与建议

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

您的常用邮箱：*

您的手机号码：*

问题描述：

当前已输入0个字，您还可以输入200个字

全部搜索
期刊论文
图书
学位论文
标准
纸本馆藏
外文资源发现
数据库导航
超星发现

高级检索

时间限定

出版年份：

文献类型

图书期刊文献学位论文多媒体

馆藏选择

电子馆藏纸本馆藏

核心期刊

全部期刊 SCI 收录期刊 SSCI 收录期刊 EI 收录期刊 CSCD 收录期刊 CSSCI 收录期刊

语言

中文英文

文献类型

期刊文献图书学位论文标准纸本馆藏

帮助

文字说明：

T=题名（书名、题名），A=作者（责任者），K=主题词，P=出版物名称，PU=出版社名称，O=机构（作者单位、学位授予单位、专利申请人），L=中图分类号，C=学科分类号，U=全部字段，Y=年（出版发行年、学位年度、标准发布年）

检索规则说明：

AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：

范例一：(K=图书馆学 OR K=情报学) AND A=范并思 AND Y=1982-2016
范例二：P=计算机应用与软件 AND (U=C++ OR U=Basic) NOT K=Visual AND Y=2011-2016

分类表

所选分类

>> <<

限定检索结果

文献类型

529 篇 会议
4 篇 期刊文献

馆藏范围

533 篇 电子文献
0 种 纸本馆藏

日期分布

学科分类号

278 篇 医学
- 151 篇 临床医学
- 83 篇 基础医学(可授医学...
- 36 篇 中西医结合
- 28 篇 药学(可授医学、理...
- 21 篇 中药学(可授医学、...
- 2 篇 公共卫生与预防医...
- 2 篇 医学技术（可授医学...
- 1 篇 中医学
248 篇 理学
- 246 篇 生物学
- 2 篇 物理学
- 1 篇 生态学
171 篇 工学
- 140 篇 化学工程与技术
- 25 篇 生物工程
- 2 篇 机械工程
- 2 篇 材料科学与工程（可...
- 2 篇 食品科学与工程（可...
- 1 篇 电子科学与技术（可...
- 1 篇 纺织科学与工程
- 1 篇 轻工技术与工程
- 1 篇 农业工程
- 1 篇 生物医学工程（可授...
- 1 篇 公安技术
71 篇 农学
- 58 篇 作物学
- 9 篇 畜牧学
- 2 篇 水产
- 1 篇 农业资源与环境
- 1 篇 植物保护
13 篇 教育学
- 13 篇 教育学

主题

10 篇 dna
4 篇 会员代表大会
4 篇 中国生物化学与分...
4 篇 学术会议
4 篇 rna
3 篇 国际会议中心
3 篇 领域专家
3 篇 生物化学
3 篇 domain
3 篇 厦门市
3 篇 pbl
2 篇 lncrnas β-thalas...
2 篇 hbv
2 篇 ampk
2 篇 白花丹参
2 篇 高通量测序
2 篇 vsmcs
2 篇 mirnas
2 篇 2型糖尿病
2 篇 sm22α

机构

13 篇 北京大学
10 篇 厦门大学
9 篇 清华大学
8 篇 山东大学
7 篇 复旦大学
7 篇 key laboratory o...
7 篇 peking universit...
7 篇 中国科学技术大学
6 篇 第四军医大学
6 篇 武汉大学
5 篇 江西中医药大学
5 篇 school of life s...
5 篇 institute of bio...
5 篇 department of bi...
5 篇 浙江大学
5 篇 河北医科大学
4 篇 institute of bio...
4 篇 school of pharma...
4 篇 军事医学科学院放...
4 篇 上海交通大学

作者

6 篇 周丛照
6 篇 qun wei
6 篇 youxin jin
6 篇 孙金鹏
5 篇 botao zhao
5 篇 xiaofeng zheng
5 篇 zhongyi cheng
5 篇 detao wang
5 篇 闫永彬
4 篇 zhihua wu
4 篇 jiali wei
4 篇 zhengping xu
4 篇 donghai lin
4 篇 guoqin jin
4 篇 li zhang
4 篇 韩梅
4 篇 陈宇星
4 篇 刘晓灵
4 篇 梁毅
4 篇 zheqi li

语言

470 篇 英文
63 篇 中文

检索条件"任意字段=中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议"

共 533 条记录，以下是161-170 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Crystal structure of juvenile hormone epoxide hydrolase from Bombyx mori

Crystal structure of juvenile hormone epoxide hydrolase from...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：周康贾宁胡晨江永亮杨捷频陈宇星李胜李卫芳周丛照中国科学技术大学生命科学学院上海生命科学研究院植物生理学和生态学研究所

Juvenile hormone(JH)epoxide hydrolase(JHEH)catalyzes JH degradation to produce juvenilehormone diol and regulates the metamorphosis development of *** wedetermined the 2.6crystal structure of JHEH from Bombyx mori(BmJHEH).The overallstructure of BmJHEH is composed of a coreα/βhydrolase domain,an all-αlid region andan N-terminal anchor *** analyses together with molecular remodeling revealnovel insights of the active-site pocket for JH *** findings increase ourunderstanding of the substrate recognition and catalysis of microsomal epoxide hydrolasesand might help the design of JH-analogue pesticides.

关键词： Bombyx mori juvenile hormone microsomal epoxide hydrolase crystal structure

来源：评论

学校读者我要写书评

暂无评论

Role of ADAMTS1 in adipogenesis

Role of ADAMTS1 in adipogenesis

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Suzhen Chen Haiyan Huang Qiqun Tang Fudan univercity

Formation of adipose tissue is a complex process requiring designation of mesodermalstem cells to a preadipocyte lineage and differentiation of preadipocytes into *** adipose tissue, the ECM is crucial for maintaining the structural integrity of adipocytesand plays a pivotal role in adipogenesis and whole tissue formation. However, the potentialimpact of ECM in adipocyte lineage commitment is still unclear. Here, our studiesshowed that the expression of ECM component ADAMTS1(a new metalloprotease) decreaesdin subcutaneous adipose tissue of obese mice when compared to lean mice. theexpression of ADAMTS1 desreased during the adipocytic lineage commitment as well. Wealso found that miR-181 d might be responsible for ADAMTS1's downregulation duringadipogenesis. Our further studies showed that ADAMTS1 plays an inhibitory role in *** the metalloprotease activity of ADAMTS1, we proposed thatADAMTS1 may contribute to the commitment of preadipocyte by remodelling *** studies will open up new opportunities for the development of drugs forobesity and its metabolic and cardiovascular complications.

关键词： ADAMTS1 Adipogenesis ECM remodeling miR-181d

来源：评论

学校读者我要写书评

暂无评论

Glycyrol suppresses collagen-induced arthritis by regulatingautoimmune and inflammatory responses

Glycyrol suppresses collagen-induced arthritis by regulating...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Yanxia Fu Hailing Zhou Shuangyan Wang Qun Wei Department of Biochemistry and Molecular Biology Beijing Normal University Gene engineering and Biotechnology Beijing Key Laboratory

Glycyrol is a natural compound extracted from Glycyrrhiza uralensis, first reported by us tobe a new immunosuppressant. Here, we demonstrate its beneficial effect in collagen-induced arthritis(CIA) in mice, a model for rheumatoid arthritis(RA) in man, and wedocument the underlying mechanisms. Peroral administration of glycyrol significantly reducedclinical scores, alleviated cartilage and bone erosion and reduced levels of serum inflammatorycytokines. Glycyrol also decreased delayed-type hypersensitivity(DTH), improvedcarbon clearance and reduced acetic acid-induced capillary permeability. Furthermore,glycyrol decreased NF B and NFAT transcriptional activities and inhibited IL-2 *** therapeutic effect of glycyrol was associated with down-regulation of bothautoimmune and inflammatory reactions. In addition, we demonstrated that glycyrol hasminimal acute toxicity in mice. Therefore, we propose that glycyrol may hold promise forfuture treatment of RA.

关键词： glycyrol rheumatoid arthritis autoimmune inflammation

来源：评论

学校读者我要写书评

暂无评论

The new Immunosuppressant, isogarcinol, binds directly to itstarget enzyme calcineurin, unlike cyclosporin A and tacrolimus

The new Immunosuppressant, isogarcinol, binds directly to it...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Juren Cen Mengqi Wang Guohua Jiang Yanxia Yin Zhenyi Su Li Tong Jing Luo YipengMa Qun Wei Department of Biochemistry and Molecular Biology Beijing Normal University Gene engineering and Biotechnology Beijing Key Laboratory

Isogarcinol, a bioactive polyisoprenylated benzophenone derivative isolated fromGarcinia mangostana L., has been shown previously to exert a strong inhibitory effect oncalcineurin and is thus a potential oral, low-toxicity immunomodulatory drug. In thepresent study, enzyme kinetic analysis showed that inhibition of calcineurin by isogarcinolwas competitive. Fluorescence spectroscopy indicated that isogarcinol bound to *** titration calorimetry showed that binding was mainly driven by enthalpy,and was exothermic because the enthalpy change exceeded the entropy reduction. The interactionforce is either hydrogen bonding or Van der Waals forces. Fluorescence resonanceenergy transfer and molecular docking experiments indicated that there were twopotential binding sites for isogarcinol in the catalytic domain of calcineurin. In summary,isogarcinol binds directly to calcineurin in vitro, unlike the classical calcineurin inhibitorscyclosporin A and tacrolimus.

关键词： isogarcinol calcineurin isothermal titration calorimetry fluorescences pectroscopy docking

来源：评论

学校读者我要写书评

暂无评论

preparation of DNA G-quadruplex structure specific antibody

preparation of DNA G-quadruplex structure specific antibody

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： yiqiang zhang Xiaoyu Lan Shuang Wang Zhirong Liu Jinyan Shen Meining Li Xingshun Liu Yuehong Zhang Jun Xie Niuliang Cheng Department of Biochemistry and Molecular Biology Shanxi Medical University

Bioinformatics research suggests guanine rich in DNA can be folded into a special kind ofsecondary structure called the G-quadruplex referred to as G4. Its widely exists in the genomepromoter regions(c-myc, c-kit, VEGF, Bcl-2) and the chromosomes which plays an importantrole for cancer gene expression and regulation of telomerase activity. So the cellstructure of G4, in tumor treatment has become a research hotspot in recent years andbeen considered to be important targets for cancer molecular targeted therapy drugs. Thisgroup constructed the DNA G-quadruplex structure specific expression vector and abundantlyexpressed in escherichia coli BL21, then purification and identification this *** antibody can be used to directly observed DNA G-quadruplex structure formation in afluorescence microscope and provide a means for drug screening in G4 stabilizer.

关键词： G-quadruplex antibody

来源：评论

学校读者我要写书评

暂无评论

Analysis of lncRNA expression profiles in major depressive disorder

Analysis of lncRNA expression profiles in major depressive d...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Tingfu Du Rongrong Han Qi Xu Institute of Basic Medical Sciences Chinese Academy of Medical Sciences

Major Depressive Disorder(MDD) is one of the most common psychiatric disorders, longnon-codingRNA(lncRNA) are found to have important regulatory *** microarrays,the expression of 37000 lncRNAs and 34000 mRNAs in peripheral blood sampled fromMDD patients(n=40)and controls(n=20)were profiled in our study. The top 20 differentiallyexpressed lncRNA and mRNA from microarray were conrmed by *** of LncRNAs were detected in another MDD patients(n=80) as well as matchedcontrols(n=80) by qPCR, cells and animals experiment were done to investigate the potentialregulatory roles in *** results of microarrays, we found that 5979 lncRNAs and6965 mRNAs were differentially expressed. Gene Ontology(GO) analysis revealed that thebiological functions ofdifferentially expressed mRNAs were related to *** are two lncRNAs significantly altered expression in MDD and play an important role in pathogenesis of MDD, it may contribute to the diagnose of MDD *** results suggest that lncRNA may contribute to the pathogenesis of MDD.

关键词： Major Depressive Disorder Microarray lncRNA

来源：评论

学校读者我要写书评

暂无评论

High-level production of biologically active human enterokinase light chain by Esherichia coli

High-level production of biologically active human enterokin...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Lixi Niu Jiayue Li Key Laboratory of Chemical Biology and Molecular Engineering of M inistry of Education Shanxi University

Human enterokinase(synonym:enteropeptidase,EC 3.4.21.9)light chain(hEKL)gene wasdesigned and artificially synthesized with built-in codon bias towards Escherichia coli(***)codon *** synthetic hEKL gene was cloned into prokaryotic expressionvector pMAL-s and transferred into the expression strain *** BL21(DE3).The recombinanthEKL protein with a maltose binding protein(MBP)tag was expressed at high levels insoluble form,yielding about 42%of the total cellular *** target protein was thenpurified to the homogeneity better than 95%by affinity *** peptide substrateGST-Melittin with enterokinase recognition site was completely cleaved by the purifiedMBP-hEKL at the molar ratio of 1:5000(enzyme:substrate).Tricine SDS-PAGE analysisshowed that the activity of MBP-hEKL was approximately seven times that of bovine enterokinasecatalytic subunit(EKMaxTM,Invitrogen).From 1 L flask culture,206 mg pure activeMBP-hEKL was obtained and the specific activity was reached to 1.4×104 U/mg.

关键词： Human enterokinase light chain(hEKL) Fusion expression Affinity purification Activity analysis

来源：评论

学校读者我要写书评

暂无评论

Predicition of Domain and three-dimensional structure of Homo sapiens PPARγ transcript variant 1 Protein

Predicition of Domain and three-dimensional structure of Hom...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： cong sun yechao Han Wenfeng zhang Department of Biochemistry and Molecular Biology School of Basical Medical Sciences Jilin Institute for Veterinary Drug and Feed Control

To predict the three-dimensional structure and binding site of ligand based on amino acidsequence of peroxisome proliferator-activated receptor gamma(PPARγ),transcript variant1 *** secondary structure and surface properties of PPARγtranscript variant 1 Proteinsuch as hydrophilicity,physical and chemical properties,surface probability,flexibleregions,trans–membrane domain,signal peptide and secondary structure were analyzedto predict its binding site of ligand by bioinformatics methods and *** threedimensionalstructure was obtained by submitting amino acid sequence to the *** potential bingding site of ligand were ***:The secondarystructure and bingding site of ligand of PPARγtranscript variant 1 Protein were predictedsuccessfully by *** study provided a foundation for identificationof its advantage binding site of ligand and understanding its biological functions on thebasis of protein structure.

关键词： PPARγ transcript variant 1 protein binding site

来源：评论

学校读者我要写书评

暂无评论

Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5

Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Zhe Zhang Tianlong Zhang Fang Yu Xu-qiao Chen Haixiang Shi Lan Bao Zhou Gong Chun Tang Shanshan Wang Jing Feng Jiangye Chen Jianping Ding State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences State Key Laboratory of Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences

Rabex-5 and Rabaptin-5 function together to activate Rab5 and further promote early endosomal fusion in *** Rabex-5 GEF activity is autoinhibited by the Rabex-5 CC domain(Rabex-5CC)and activated by the Rabaptin-5 C2-1 domain(Rabaptin-5C21)with yet unknown *** report here the crystal structures of Rabex-5 in complex with the dimeric Rabaptin-5C21(Rabaptin-5C212)and in

关键词： Rab Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5 domain GEF

来源：评论

学校读者我要写书评

暂无评论

Decipher biological significance of the novel epitranscriptomic marker N6-Methyadenosine(m6A) in RNA

Decipher biological significance of the novel epitranscripto...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Yun-Gui Yang CAS Key Laboratory of Genomics and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences

The N6-methyladenosine(m6A)modification is one of the most frequently methylated nucleotides in eukaryotic mRNA,accounting for over 80%of all RNA base methylations and present in various *** two independent studies combining m6A-immunoprecipitation with high throughput analysis revealed that the m6A modification tends to mainly occur in intragenic regions including coding sequences(CDS),stop codon flanking regions and 3’-*** frequency was especially high in the 3’-end of CDS and the first quarter of the 3’-UTR,with an average of 1 m6A per 2000 *** m6A modification occurs in highly conserved regions with the consensus sequence:RRACH(R=G or A;H=A,C or U).During the course of brain development a

关键词： in RNA Decipher biological significance of the novel epitranscriptomic marker N6-Methyadenosine m6A

来源：评论

学校读者我要写书评

暂无评论

没有更多数据了...

全选清除本页清除全部题录导出标记到“检索档案”

共54页 << < 13 14 15 16 17 18 19 20 21 22 > >>

检索报告对象比较合并检索0

隐藏清空

合并搜索

回到顶部

执行限定条件

内容：

评分：

请选择保存的检索档案：

请选择收藏分类：

订阅名称：

通借通还

温馨提示：

图书名称：

借书校区：

取书校区：

手机号码：

邮箱地址：

一卡通帐号：

电话和邮箱必须正确填写，我们会与您联系确认。

联系人：

所在院系：

联系邮箱：

联系电话：

内蒙古自治区呼和浩特市赛罕区大学西街235号邮编: 010021

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：