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检索条件"任意字段=中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议"

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Real-time monitoring in Live cells using infrared spectroscopy

Real-time monitoring in Live cells using infrared spectrosco...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：边迅 Andrew K.L Chan King’s College London Pharm. Science Research Division

Infrared(IR) spectroscopy is widely employed in structure analysis and quantitative analysisof organics. Since it is a labelfree and non-destructive chemical analysis method, it canbe applied to study on live cells. In order to keep the cells alive and not to be contaminatedduring measurement, an ordinary cell culturing flask has been modified such that livecells can be cultured on CaF2 window. However, the major parts of living cells are water,which takes about 70 weight percentages. Since water molecules are the most abundantchromosphere in in the sample, therefore, strong absorption bands of water will interfereon the results. In order to reduce the interference of water absorption bands, the flaskswere standing erect for a while, the water bands became weaker and the cell band appearedapparently. After the measurement, a Trypan blue essay had been *** on the success of measuring live cells, the methods have been applied to trace thechanges in cells. One is to detect the changes in cells after changing the medium with theone without pyruvate;the other is to explore the changes of ATP in cells after addingTyrphostin 9. The results are in keeping with expectation;the changes of ATP level havebeen detected successfully.

关键词： FTIR live cells protein real-time monitoring ATP

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The Calcineurin B subunit(CnB) synergizes with interferon-γ toactivate RAW264.7 macrophages via integrin αM–p38 MAPK–STAT1 signaling pathway

The Calcineurin B subunit(CnB) synergizes with interferon-γ...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Zhenyi Su Lan Xu Wenlong Zhang Rui Yang Yanxia Yin Youxiu Zhong Juren Chen Qun Wei Department of Biochemistry and Molecular Biology Beijing Normal University Gene engineering and Biotechnology Beijing Key Laboratory

We have shown previously that the calcineurin B subunit(CnB) plays an important role ininnate immunity, but little is known of the interactions between CnB and key ***, we report that CnB and interferon-γ(IFN-γ) have a remarkable synergistic effect oninduction of typical IFN-γ response genes(e.g., CXCL9, CXCL10, iNOS, TRAIL) in RAW264.7macrophages. We also reveal that STAT1 is a key factor orchestrating the synergy of CnBand IFN-γ, which is coactivated by CnB-engaged integrin αM-p38 MAPK signaling andIFN-γ-initiated signaling. In addition, combination of CnB and IFN-γ greatly increases thecytotoxicity of RAW264.7 macrophages.

关键词： calcineurin B subunit interferon-γ synergy STAT1 p38 MAPK integrin αM

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Crystal structure of the WOPR-DNA complex and implications for Wor1 function in white-opaque switching of Candida albicans

Crystal structure of the WOPR-DNA complex and implications f...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Shicheng Zhang Tianlong Zhang Minghui Yan Jianping Ding Jiangye Chen SIBCB S IBS.CAS

Wor1 is a master regulator of the white-opaque switching in Candida albicans,an opportunistichuman fungal pathogen,and is associated with its pathogenicity and ***1 contains a conserved DNA-binding region at the N-terminus consisting of twoconserved segments(WOPRa and WOPRb)connected by a non-conserved linker that canbind to specific DNA sequences of the promoter regions and then regulates the ***,we report the crystal structure of the *** Wor1 WOPR segments in complexwith a double-stranded DNA corresponding to one promoter region of *** separated WOPRa and WOPRb are structurally interwound together to form acompact globular domain we term the WOPR *** WOPR domain represents anew conserved fungal specific DNA-binding domain which uses primarily a conserved loopto recognize and interact specifically with a conserved six-base motif of the DNA in bothminor and major *** protein-DNA interactions are essential for WOR1 transcriptionalregulation and white-to-opaque *** structural and biological data togetherreveal the molecular basis for the recognition and binding specificity of the WOPRdomain with its specific DNA sequences and the function of Wor1 in the activation of transcription.

关键词： white-opaque switching protein-DNA recognition transcriptional regulation crystal structure

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Resonance Light Scattering Measurement of DNA by o-Hydroxyphenyl Fluorone

Resonance Light Scattering Measurement of DNA by o-Hydroxyph...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：夏循礼江西中医药大学

Quantitative analysis of nucleic acids is an important area in the chemical analysis and *** are many kinds of methods,such as Spectrophotometry,Fluorimetryand Electrochemical method,to make quantitative analysis for nucleic *** his research on porphyrin compounds congregating with nucleic acid by ResonanceLight Scattering(***)method and applied it to samples analysis in *** then has being widely applied for chemical analysis because of simple experimentalapparatus need and high *** 1996,Huang Chengzhi et al established anew method which is mainly based on the aggregation of dye chromophore in biologicalmacromolecules,which resulting in strong enhancement of resonance light *** Light Scattering Measurement of DNA by O-hydroxyphenyl fluorone(o-HPF)isbased on the enhancement effect of the Resonance Light Scattering(RLS)due to the combinationof o-HPF with *** this paper,a Resonance Light Scattering Method for DNAmeasurement was established by using o-hydroxyphenyl fluorone(ab.o-HPF)as a probereagent and calf thymus DNA as researching *** the TrisHCl buffer solution at pH8.1,the RLS intensity is proportional to the concentration of DNA in the range of 0.02-1.8×10-5 g·*** detection limit is 4.6×10-8 g·*** method is simple,rapid,highaccuracy and has been applied to the determination of DNA concentration with satisfactoryresults.

关键词： o-Hydroxyphenyl fluorone Resonance light scattering DNA measurement

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MicroRNA-18a suppresses LXRγ expression in human neuroblastoma cells and hepatocytes

MicroRNA-18a suppresses LXRγ expression in human neuroblast...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Dan-Dan Shang Xin Xin Mei Han Hebei Medical University

The liver X receptor α(LXRα, NR1H3) and LXRβ(NR1H2) are members of the nuclear hormonereceptor *** play a critical role in the transcriptional control of lipidmetabolism. MicroRNAs(miRs) are regarded as important negative regulators of gene *** has been reported that miR-1/miR-206 suppress LXRα-induced lipogenesis inhepatocytes. However, the regulation of LXRβ by microRNAs is not fully understood. In thisstudy, we found that miR-18 a repressed LXRβ expression in both human neuroblastomacells and hepatocytes at both mRNA and protein levels. In addition, bioinformatics analysiswith TargetScan and PicTar predicted a putative target-site for miR-18 a located within the3'-untranslated region(3'-UTR) of LXRβ mRNA. To verify our prediction, HEK293 cellswere cotransfected with reporters(pMIR-LXRβ) and miR-18 a mimics. We found that miR-18 a inhibited the luciferase activity of LXRβ 3'-UTR reporter,suggesting that miR-18 adirectly target the 3'-UTR of LXR β mRNA. Taken together, we for the first time demonstrated that miR-18 a repressed LXRβ expression by targeting the 3'-UTR of LXRβ mRNA.

关键词： LXRβ miR-18a

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Immune-regulation and anti-inflammatory effects of isogarcinol extracted from Garcinia mangostana Linn against collagen-inducedarthritis

Immune-regulation and anti-inflammatory effects of isogarcin...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Yanxia Fu Hailing Zhou Mengqi Wang Juren Chen Qun Wei Department of Biochemistry and Molecular Biology Beijing Normal University Gene engineering and Biotechnology Beijing Key Laboratory

Isogarcinol is a natural compound that we extracted from Garcinia mangostana Linn, andwe were the first to report that it is a new immunosuppressant. In the present study, we investigatedthe immune-regulation and anti-inflammatory effects of isogarcinol on collagen-induced arthritis(CIA) and explored its potential mechanism in the treatment ofrheumatoid arthritis. The oral administration of isogarcinol significantly reduced clinicalscores, alleviated cartilage and bone erosion and reduced the levels of serum inflammatorycytokines in CIA mice. Isogarcinol inhibited acetic acid-induced capillary permeability andxylene-induced mouse ear edema in vivo. In vitro, isogarcinol decreased iNOS mRNA transcriptionand NO content in LPS stimulated macrophagocytes by inhibiting NF-κB transcriptionalactivity. Furthermore, isogarcinol decreased the transcriptional activity of NFATand inhibited IL-2 expression. The mechanism of action of isogarcinol is associated withdown-regulation of both autoimmune and inflammatory reactions.

关键词： Garcinia mangostana Linn isogarcinol collagen-induced arthritis inflammation,immunity

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Multilevel structural characteristics for the natural substrate proteins of bacterial small heat shock proteins

Multilevel structural characteristics for the natural substr...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：付新苗北京大学生命科学学院

Small heat shock proteins(sHSPs)play crucial roles for protein quality control in *** ispoorly understood what natural substrate proteins,with respect to structural characteristics,are preferentially bound by sHSPs in *** I compared the structural characteristicsfor the natural substrate proteins of Escherichia coli IbpB and Deinococcus radioduransHsp20.2with the respective bacterial *** indicate that both IbpB and Hsp20.2preferentially bind to substrates of high molecular weight or moderate ***,their substrates contain abundant charged residues but not abundant hydrophobicresidues,thus strongly indicating that ionic interactions other than hydrophobic interactionsalso play crucial roles for the substrate recognition and binding of ***,secondary structure prediction analysis indicates that thesubstrates of low percentage ofβ-sheets or coils but high percentage ofα-helices are un-favored by both IbpB *** addition,IbpB preferentially interacts with multi-domain proteins but unfavorablywithα+βproteins as revealed by SCOP ***,our data suggest that bacterialsHSPs,though having broad substrate spectrums,selectively bind to substrates ofcertain structural *** structural characteristic elements may substantially participatein the sHSPsubstrate interaction and/or increase the aggregation tendency of thesubstrates.

关键词： molecular chaperone small heat shock protein structural prediction natural substrate proteins

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Geniposide Regulates Glucose-Stimulated Insulin Secretion Possibly through Controlling Glucose Metabolism in INS-1 Cells

Geniposide Regulates Glucose-Stimulated Insulin Secretion Po...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：郭莉霞 Chongqing Key Laboratory of Catalysis & Functional Organic Molecules Chongqing Technology and Business University

Glucose-stimulated insulin secretion(GSIS) is essential to the control of metabolic fuelhomeostasis. The impairment of GSIS is a key element of β-cell failure and one of causes oftype 2 diabetes mellitus(T2DM). Although the KATP channeldependent mechanism ofGSIS has been broadly accepted for several decades, it does not fully describe the effectsof glucose on insulin secretion. Emerging evidence has suggested that other mechanismsare involved. The present study demonstrated that geniposide enhanced GSIS in responseto the stimulation of low or moderately high concentrations of glucose, and promotedglucose uptake and intracellular ATP levels in INS-1 cells. However, in the presence of ahigh concentration of glucose, geniposide exerted a contrary role on both GSIS and glucoseuptake and metabolism. Furthermore, geniposide improved the impairment of GSIS inINS-1 cells challenged with a high concentration of glucose. Further experiments showedthat geniposide modulated pyruvate carboxylase expression and the production of intermediatesof glucose metabolism. The data collectively suggest that geniposide has potentialto prevent or improve the impairment of insulin secretion in β-cells challenged withhigh concentrations of glucose, likely through pyruvate carboxylase mediated glucosemetabolism in β-cells.

关键词： GSIS geniposide

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The roles of long non-coding RNAs in renal cell carcinomas development

The roles of long non-coding RNAs in renal cell carcinomas d...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Xiaoqiang Guo Ming Xia Weiren Huang Zhiming Cai Shenzhen Key Laboratory of Genitourinary Tumor Shenzhen Second People's Hospital First Affiliated Hospital of Shenzhen University

Long non-coding RNAs(long ncRNAs, lncRNA) are non-protein coding transcripts longerthan 200 nucleotides. lncRNAs play important roles in a wide range of biological processessuch as the regulation of gene transcription, post-transcriptional regulation,and epigeneticregulation, and dysregulated lncRNAs are involved in cancer. In this study, the expressionsof several lncRNAs including homeobox(HOX) transcript antisense intergenic RNA(HOTAIR), metastasis-associated lung adenocarcinoma transcript 1(Malat-1) and lincRNA-p21 were measured with quantitative real-time polymerase chain reaction(qRT-PCR)in cancer tissues and adjacent normal tissues of 48 paired renal cell carcinomas(RCC). Theresults indicated the RNA levels of three lncRNAs HOTAIR, Malat-1 and lincRNA-p21 aredysregulated, and the contents of three lncRNAs are associated with partly clinical data. It demonstrated that lncRNAs abnormality is an important reason for development of RCC,and the mechanism is required to be further investigated.

关键词： lncRNA renal cell carcinomas HOTAIR Malat-1 lincRNA-p21

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A light switch to control circadian rhythms

A light switch to control circadian rhythms

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Liting Liting Yang Sen Liu Institute of Molecular Biology China Three Gorges University

Biological clock is an endogenous rhythmicity keeping mechanisms,which is ubiquitousphenomenon in biological *** rhythms regulate various metabolic and behavioralactivities and have evolved as an adaptation to daily changes in environmental *** is the model organism to study the molecular mechanisms of circadianand its circadian clock can be reconstituted in vitro by mixing recombinant KaiA,KaiB andKaiC proteins with ATP,producing KaiC phosphorylation and dephosphorylation cyclesthat have a regular rhythm with a 24-h *** KaiA enhances the phosphorylationactivity of KaiC while protein KaiB antagonizes this *** C-terminal KaiA domain alone is sufficient in vitro to promote the phosphorylation ofKaiC,but it also remains to be seen whether it affects the circadian clock.C-terminal domainof KaiA adopts a novel four a-helical homodimeric *** first Ja helix do notinteract with kaiC directly suggested by the crystal structure and modeling *** use Jahelix of the AsLOV2 domain to replace the first Ja helix while maintaining AsLOV2 structurein the dark but allowing kaiA to bind to kaiC proteins when the Ja helix unfolds in *** hope this light switch can control KaiC de/phosphorylation,which in turn can affectthe rhythm of this molecular oscillator.

关键词： Circadian Clock Protein Design KaiA/KaiB/KaiC

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