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检索条件"任意字段=中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议"

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The roles of long non-coding RNAs in renal cell carcinomas development

The roles of long non-coding RNAs in renal cell carcinomas d...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Xiaoqiang Guo Ming Xia Weiren Huang Zhiming Cai Shenzhen Key Laboratory of Genitourinary Tumor Shenzhen Second People's Hospital First Affiliated Hospital of Shenzhen University

Long non-coding RNAs(long ncRNAs, lncRNA) are non-protein coding transcripts longerthan 200 nucleotides. lncRNAs play important roles in a wide range of biological processessuch as the regulation of gene transcription, post-transcriptional regulation,and epigeneticregulation, and dysregulated lncRNAs are involved in cancer. In this study, the expressionsof several lncRNAs including homeobox(HOX) transcript antisense intergenic RNA(HOTAIR), metastasis-associated lung adenocarcinoma transcript 1(Malat-1) and lincRNA-p21 were measured with quantitative real-time polymerase chain reaction(qRT-PCR)in cancer tissues and adjacent normal tissues of 48 paired renal cell carcinomas(RCC). Theresults indicated the RNA levels of three lncRNAs HOTAIR, Malat-1 and lincRNA-p21 aredysregulated, and the contents of three lncRNAs are associated with partly clinical data. It demonstrated that lncRNAs abnormality is an important reason for development of RCC,and the mechanism is required to be further investigated.

关键词： lncRNA renal cell carcinomas HOTAIR Malat-1 lincRNA-p21

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Synthesis of a Biotinylated Probe for Scutellarein with Anti-Tumor Activity

Synthesis of a Biotinylated Probe for Scutellarein with Anti...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Bin He Sun Zhang Min Wang Xiaoyan Liu Jun Cui Yan Li Guiyang Medical University

Traditional Chinese Medicines(TCMs) have been used clinically in treating many humandiseases for a long period, which are regarded as potential sources for drug ***(or Scutellarein-7-O-glucuronide), A clinic natural drug consisting of totalflavonoids of Erigeron breviscapus(Vant.) Hand-Mazz.(Compositae), has been used for thetreatment of cerebral infarction, coronary heart disease, angina pectoris and other cardiocerebrovasculardiseases in China. Besides, recent study shows that Scutellarin diminishedthe proliferation of B-lymphoma Namalwa cells in vitro and inhibited lymphomagrowth in Namalwa cell-xenotransplanted mice without obvious *** to the significance of scutellarin in the clinical therapy, Scutellarin has been attractedmore and more attentions in recent years. Therefore, we come up two interesting questionsto ask: What's the mechanism of Scutellarin in treating cancer? Howcan we developbetter compounds for treating cancer based on the scaffold of Scutellarin?To address these two questions, we design and synthesize a biotinylated probe of *** further demonstrate that this probe as an analogue of Scutellarin shows similaranti-tumor activity, which can be used as a tool to study on direct targets of Scutellarin incancer treatment.

关键词： Scutellarin Scutellarein Flavonoid Anti-Tumor Biotinylated Probe

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An improved uniblue A-based staining method and its applications for protein analyses

An improved uniblue A-based staining method and its applicat...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：邢天禹窦云鹏姚婷张晨光丁卫 Department of Medical Genetics School of Basic Medical Sciences Capital Medical University Department of Immunology School of Basic Medical Sciences Capital Medical University Cancer Institute Capital Medical University Beijing Institute of Brain Disorders

Uniblue A and its derivatives are a class of low-cost dyes that can be used to covalently labelproteins. The efficiency of staining, in companion with the subsequent detection methods,is critical for the application of uniblue A-based protein identification and ***, the current advances of near infrared laser scanning equipments have provided the possibility to uniblue A stained proteins with high sensitivity. In this study, we developed a quick, easy, and reliable protein staining method to efficiently label purifiedor mixture proteins. The labeled proteins can be directly subjected to rapid separation and identification by SDS-PAGE. The method exerts practical potentials for the applications to the controlled productions of prestained protein samples, as well as the relabeling prior to mass spectrum analysis. By using different equipments' with infrared detection capabilities,versatile applications of our staining methods were demonstrated, including in-gel western blot for post-identification of specific antigens, and fluorescent microscopy to profile the intracellular distribution of the labeled proteins.

关键词： Uniblue A Protein staining SDS-PAGE In-Gel Western Fluorescent microscopy

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Expression and prognostic significance of CK2α and Survivin inhuman ovarian epithelial tumors

Expression and prognostic significance of CK2α and Survivin...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：刘超刘乙蒙吴爽张晓玉肖建英辽宁医学院

Objective To study the expression of CK2αand Survivin in ovarian tumors,and toanalyze the correlation between CK2αor Survivin and MMP-2/*** further exploretheir relationship with tumor invasion and *** Surgical specimens in paraffinof 13 cases of simple ovarian cysts,13 cases of ovarian benign tumor and 38 cases ofovarian cancer tissue samples,and 10 cases of normal ovarian tissue were collected fromthe First Affiliated Hospital of Liaoning Medical *** expression levels of CK2α,Survivin and MMP-2/MMP-9 were detected with immunohistochemical SP *** expression levels of CK2αand Survivin protein in ovarian cancer were significantlyhigher than those in simple ovarian cysts and ovarian benign tumor(P<0.01).The expressionof CK2αand Survivin protein was correlated with histological grade and clinicalstage(P<0.05).The expression of CK2αor Survivin was positive correlated with that ofMMP2/9(P<0.05).Conclusion The upregulation of CK2αor Survivin expression and thecorrelation with MMP-2 or MMP-9 are related to the progression and invasion or metastasisof ovarian *** may become a new therapeutic target for early diagnosis ofovarian cancer.

关键词： CK2α Survivin immunohistochemistry ovarian cancer

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The role and mechanism of hypoxia-regulated histonedemethylases in renal carcinoma development

The role and mechanism of hypoxia-regulated histonedemethyla...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Xiaoqiang Guo Zhantao Tian Ming Xia Xianglin Duan Zhiming Cai Shenzhen Key Laboratory of Genitourinary Tumor Shenzhen Second People's Hospital First Affiliated Hospital of Shenzhen University Laboratory of Molecular Iron Metabolism College of Life Science Hebei Normal University

Jumonji domain-containing(JmjC) histone demethylases are a kind of Fe(Ⅱ) and α-ketoglutarate-dependent dioxygenases. Previous studies have donmomstated that severalhistone demethylases were regulated by hypoxia and involved in hypoxia signaling *** results show that H3K9me1/2 demethylase JMJD1 A and H3K27me2/3 demethylaseJMJD3 are upregulated in cancer tissue of renal cell carcinoma(RCC). The expressions of JMJD1 A and JMJD3 are regulated by hypoxia in RCC cell lines and dependent on hypoxia induced factor 2α(HIF 2α). JMJD1 A or JMJD3 can interact with HIF 2α to formhypoxia activated complex, which is important for expression of hypoxia response *** these results demonstrate JMJD1 A and JMJD3 are essential factors for RCC development as regulators in hypoxia signaling pathway.

关键词： histone demethylase renal cell carcinoma JMJD1A JMJD3 hypoxia signalingp athway

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Cadmium is a potent inhibitor of PPM phosphatases and targetsthe M1 binding site.

Cadmium is a potent inhibitor of PPM phosphatases and target...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：汤俊宜潘畅孙金鹏山东大学

The heavy metal cadmium is a non-degradable pollutant. By screening the effects of apanel of metal ions on the phosphatase activity, we unexpectedly identified cadmium as apotent inhibitor of PPM1 A and PPM1 G. In contrast, low micromolar concentrations of cadmiumdid not inhibit PP1 or tyrosine phosphatases. Kinetic studies revealed that cadmiuminhibits PPM phosphatases through the M1 metal ion binding site. In particular, the negativecharged D441 in PPM1 G specific recognized cadmium. Our results suggest that cadmiumis likely a potent inhibitor of most PPM family members except for PHLPPs. Furthermore,we demonstrated that cadmium inhibits PPM1A-regulated MAPK signaling andPPM1G-regulated AKT signaling potently in vivo. Cadmium reversed PPM1A-induced cellcycle arrest and cadmium insensitive PPM1 A mutant rescued cadmium induced cell *** together, these findings provide a better understanding of the effects of the toxicityof cadmium in the contexts of human physiology and pathology.

关键词： PP2C cadmium

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Simulating Conformational Transitions of Proteins by Accelerating Collective Motions Obtained from Principal Component Analysis

Simulating Conformational Transitions of Proteins by Acceler...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Junhui Peng University of Science and Technology of China

Enhanced sampling methods remain continuing interest over the past decades becausethey are able to explore conformational space of proteins much more extensively thanconventional molecular dynamics(MD)*** report a new sampling methodthat utilizes a few collective modes obtained from principal component analysis(PCA)toguide the MD *** multi-domain proteins,bacteriophage T4 lysozyme andhuman vinculin,are studied to test the *** updating the PCA modes with a properfrequency,our method can sample large-amplitude conformational transitions of the proteinsmuch more efficiently than standard *** those PCA modes are calculated fromstructural ensembles generated by all-atom simulations,the method may overcome an inherentlimitation called"tip effect"that would possibly appear in those sampling techniquesbased on coarse-grained normal mode *** algorithm proposed here ispotentially very useful,such as developing tools for flexible fitting of protein structures integratingcryo-electron microscope or small-angle X-ray scattering(SAXS)*** the use of this method in two proteins with their SAXS data,which are bacteriophageT4lysozyme and tandem WW domains of the formin-binding protein 21,*** results show that conformations generated by this method are significantlybetter in reproducing the SAXS data than those from the MD simulations.

关键词： enhanced sampling techniques collective motions principal component analysis

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Pachytene piRNAs Instruct Massive mRNA Elimination during LateSpermiogenesis

Pachytene piRNAs Instruct Massive mRNA Elimination during La...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Lan-Tao Gou Peng Dai Jian-Hua Yang En-Duo Wang Mo-Fang Liu Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences State Key Laboratory of Biocontrol Sun Yat-sen University

Spermatogenesis in mammals is characterized by two waves of piRNA expression:one correspondsto classic piRNAs responsible for silencing retrotransponsons and the secondwave is predominantly derived from non-transposon intergenic regions in pachytene spermatocytes,but the function of these pachytene piRNAs is largely ***,we reportthe involvement of pachytene piRNAs in instructing massive mRNA elimination inmouse elongating *** demonstrate that a piRNA-induced silencing complex(pi-RISC)containing murine PIWI(MIWI)and deadenylase CAF1 is selectively assembled inelongating spermatids,which is responsible for inducing mRNA deadenylation and decayvia a mechanism that resembles the action of miRNAs in somatic *** a highly orchestratedprogram appears to take full advantage of the enormous repertoire of diversifiedtargeting capacity of pachytene piRNAs derived from non-transposon intergenic *** findings suggest that pachytene piRNAs are responsible for inactivating vastcellular programs in preparation for sperm production from elongating spermatids.

关键词： pachytene piRNAs MIWI CAF1 pi-RISC mRNA deadenylation elongatings permatids

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C/EBPβ-regulated Autophagy Facilitates Adipogenesis

C/EBPβ-regulated Autophagy Facilitates Adipogenesis

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Liang Guo Jia-Xin Huang Qi-Qun Tang Key Laboratory of Molecular Medicine the Ministry of Education Department of Biochemistry and Molecular Biology Fudan University Shanghai Medical College

Autophagy is a highly conserved self-digestion pathway involved in various physiologicaland pathophysiological *** studies have implicated a pivotal role of autophagyin adipocyte differentiation,but the molecular mechanism for its role and how it isregulated during this process is not ***,we show that CCAAT/enhancer-bindingproteinβ(C/EBPβ),an important adipogenic factor,is required for the activation of autophagyduring 3T3-L1 adipocyte *** autophagy-related gene Atg4b is identifiedas a de novo target gene of C/EBPβand plays an important role in ***,autophagy is required for the degradation of Klf2 and Klf3,two negative regulators of adipocyte differentiation,which is mediated by the adaptorprotein p62/***,the regulation of autophagy by C/EBPβand the role ofautophagy in Klf2/3 degradation and in adipogenesis are further confirmed in *** data describe a novel function of C/EBPβin regulating autophagy and revealthe mechanism of autophagy during adipocyte *** new insights into themolecular mechanism of adipose tissue development provide a functional pathway withtherapeutic potential against obesity and its related metabolic disorders.

关键词： 3T3-L1 preadipocytes Adipogenesis C/EBPβ Autophagy Atg4b

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miRNA disturbance by loss of Lkb1 in KrasG12D non-small celllung cancer

miRNA disturbance by loss of Lkb1 in KrasG12D non-small cell...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Qian Zhang Huizhong Bao Youxin Jin Institute of Biomedicine and Biotechnology SIAT CAS Institute of Biochemistry and Cell Biology SIBS CAS

Non-small cell lung cancer(NSCLC) accounts for 80–85% of total lung cancer cases withextremely high mortality rates,which can be ameliorated by early diagnosis. Activation ofKRAS and inactivation of tumor suppressor LKB1 are common gene mutations detected inmultiple subtypes of NSCLCs. Concurrence of LKB1 loss with Kras oncogenic mutationsresults in higher malignancy of lung cancer. However, the LKB1- related characteristic microRNAs(miRNA) and their contribution to the malignant progression keeps unknown. Inthis study, miRNAs profiles were elucidated by deep sequencing of both KrasG12 D andKrasG12D Lkb1-/- mouse NSCLC tissues which stand for non-malignant and malignant tumorrespectively, with the lung of wild type C57BL/6 as normal control. Gene function analyses were performed for the targets of significant changed miRNAs to identify the functionof miRNAs, which further confirmed in human NSCLCs, elucidating the diagnostic potentialof miRNAs.

关键词： NSCLC Lkb1 Kras miRNA

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