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检索条件"任意字段=中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议"

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Anti-Enterovirus 71 Effects of Amphotericin B

Anti-Enterovirus 71 Effects of Amphotericin B

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Fengwen Xu Tingting Liu Xiaoxiao Zhao Fei Guo Institute of Pathogen Biology Chinese Academy of Medical Sciences and Peking Union Medical College

Enterovirus 71(EV71) can cause severe disease and even lead to death in children, and aneffective antiviral drug is currently unavailable. Amphotericin B has been used to treat systemicfungal infections, including Aspergillosis, since the 1950’s, and its clinical formulationsare currently used widely to treat a growing number of such cases. Amphotericin Bwas reported to exhibit antiviral effects against vesicular stomatitis virus, herpes simplexvirus types 1 and 2, and Sindbisvirus. We found that Amphotericin B could inhibit EV71 proliferation and Amphotericin B could block the attachment and entry of EV71 to hostcells to regulate the early stage of EV71 infection. Our results are helpful to understand themechanism for EV71 life cycle and provide a potential for the usage of an approved drugagainst EV71 infection.

关键词： EV71 Amphotericin B

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Analysis of lncRNA expression profiles in major depressive disorder

Analysis of lncRNA expression profiles in major depressive d...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Tingfu Du Rongrong Han Qi Xu Institute of Basic Medical Sciences Chinese Academy of Medical Sciences

Major Depressive Disorder(MDD) is one of the most common psychiatric disorders, longnon-codingRNA(lncRNA) are found to have important regulatory *** microarrays,the expression of 37000 lncRNAs and 34000 mRNAs in peripheral blood sampled fromMDD patients(n=40)and controls(n=20)were profiled in our study. The top 20 differentiallyexpressed lncRNA and mRNA from microarray were conrmed by *** of LncRNAs were detected in another MDD patients(n=80) as well as matchedcontrols(n=80) by qPCR, cells and animals experiment were done to investigate the potentialregulatory roles in *** results of microarrays, we found that 5979 lncRNAs and6965 mRNAs were differentially expressed. Gene Ontology(GO) analysis revealed that thebiological functions ofdifferentially expressed mRNAs were related to *** are two lncRNAs significantly altered expression in MDD and play an important role in pathogenesis of MDD, it may contribute to the diagnose of MDD *** results suggest that lncRNA may contribute to the pathogenesis of MDD.

关键词： Major Depressive Disorder Microarray lncRNA

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preparation of DNA G-quadruplex structure specific antibody

preparation of DNA G-quadruplex structure specific antibody

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： yiqiang zhang Xiaoyu Lan Shuang Wang Zhirong Liu Jinyan Shen Meining Li Xingshun Liu Yuehong Zhang Jun Xie Niuliang Cheng Department of Biochemistry and Molecular Biology Shanxi Medical University

Bioinformatics research suggests guanine rich in DNA can be folded into a special kind ofsecondary structure called the G-quadruplex referred to as G4. Its widely exists in the genomepromoter regions(c-myc, c-kit, VEGF, Bcl-2) and the chromosomes which plays an importantrole for cancer gene expression and regulation of telomerase activity. So the cellstructure of G4, in tumor treatment has become a research hotspot in recent years andbeen considered to be important targets for cancer molecular targeted therapy drugs. Thisgroup constructed the DNA G-quadruplex structure specific expression vector and abundantlyexpressed in escherichia coli BL21, then purification and identification this *** antibody can be used to directly observed DNA G-quadruplex structure formation in afluorescence microscope and provide a means for drug screening in G4 stabilizer.

关键词： G-quadruplex antibody

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Construction a mouse model for tumor targeted diagnose by NIRimaging

Construction a mouse model for tumor targeted diagnose by NI...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：嘎琴 Research Center for High Altitude Medicine Qinghai University

Objective To construct NIR-imaging FA-OCC-QDs probes mediated tumors metastasisdiagnosed mouse model. Method We synthesized a biodegradable N-octyl-O,Ncarboxymethyl chitosan-folic acid conjugate(OCC-FA)coated QuantumDots(QDs).To examine tumor targeting efficiency and the cytotoxicity of FA-OCCQDs,fluorescence microscope and MTT assays was used. Furthermore,NIR-imagingand pathological. section were utilized to investigate the effects of OCC-FA- QDs on detectingmetastasis in nude mice model of *** Our result was shown thatFA –OCC- QDs with tumor targeting efficiency and low cytotoxicity in vitro,and the OCCFA-QDs mediated experimental metastatic model was successful metastatic-diagnosesystem for tumors micro- metastasis mechanism investigation in *** Wedesigned and synthesized a novel tumor targeting probe with NIR- imaging character andwe constructed an intra-vital,precise and all-purpose an-imal model to diagnose meta static cells in vivo. It will provide a powerful tool for basic research and drug-development of tumor metastasis.

关键词： NIR-imaging Nude mice Tumor metastasis Chitosan derivate

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Reciprocal regulation between thioredoxin(system) and adiponecin

Reciprocal regulation between thioredoxin(system) and adipon...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：刘金生钟良玮 College of Life Sciences University of Chinese Academy of Sciences

Adiponectin is one of the most abundant adipokines secreted by *** circulatinglevel represents up to 0.05%of total plasma *** the bloodstream,adiponectin existsmainly in three different oligomeric forms,i.e.,trimers,hexamers and high-molecularweight(HMW)*** different forms of adiponectin have somehow different functionsvia its corresponding receptors,such as AdipoR1 and/or *** adiponectinis reported to be most active *** have found that thioredoxin system,consisting ofthioredoxin,thioredoxin reductase and NADPH,promotes the reduction of HWM adiponectininto hexamers,trimers or even *** reaction does not occur *** contrast,the inhibitory effect of adiponectin,especially monomer adiponectin,on thioredoxin expression has been observed in human bronchia epithelial *** regulation between adiponectin and thioredoxin has clinical *** instance,the serum levels of adiponectin are increased as levels of thioredoxin decrease inpatients with chronic obstructive pulmonary disease(COPD).Thioredoxin is most likely tobe a critical mediator of the crosstalk between adponectin and thioredoxin system.

关键词： adiponectin thioredoxin system

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Establishment and optimization of semen alkaline single cell gelelectrophoresis

Establishment and optimization of semen alkaline single cell...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Shuang DENG Lang FANG Ke-qian XU Department of Medical Laboratory Xiangya School of Medicine Central South University

Objective To investigate the main factors of semen alkaline single cell gel electrophoresis(SCGE) and optimize the conditions, which can conductive to the developmentof recommended standard operating. Methods DNA fragmentation of sperm treated withdifferent concentrations of H2O2 was determined by alkaline SCGE. Gel layers, pH duringunwinding and electrophoresis, time of unwinding or electrophoresis and sperm countswere optimized. The reproducibility of optimized method was analyzed. Results Three layerscould reduce backgroud. PH10 was the optimal pH during unwinding and electrophoresis.40 minutes and 30 minutes were best time for unwinding and *** sperm was adequate. The intra-assay reproducibility of SCGE were 2.26%(1.29%), and the inter-assay reproducibility were 7.63%(5.84%). Conclusion Optimized semen SCGE was an repeatable and easily standardized method for clinical application.

关键词： semen DNA damage reproducibility alkaline single cell gel electrophoresis

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Cell death, the p53 family, and cancer

Cell death, the p53 family, and cancer

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Melino G MRC Toxicology Unit Leicester LE1 9HN UK University of Rome Tor Vergata 00133 Rome Italy

In the last ten years,p63 and p73 have been identified as the ancestral members of the p53 *** the high sequence and structural similarity,the mouse knockouts revealed a crucial role in neural development for p73 and in epidermal formation for *** identified several transcriptional targets,the mechanisms of regulation of cell death,and the p63 isoform involved in epithelial *** genes are involved in female infertility and maternal reproduction(AJ Levine,Nature Rev MCB 2011)as well as in cancer formation(G Melino,CDD 2011;P Tucci PNAS-USA 2012),although with distinct ***73 knockout mice(TW Mak,G&D 2008)show high tumor incidence with hippocampal dysegensis(M Agostini,PNAS-USA 2012).Conversely,ΔNp73 knockout mice(TW Mak,G&D 2010)

关键词： the p53 family and cancer Cell death

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Predicition of Domain and three-dimensional structure of Homo sapiens PPARγ transcript variant 1 Protein

Predicition of Domain and three-dimensional structure of Hom...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： cong sun yechao Han Wenfeng zhang Department of Biochemistry and Molecular Biology School of Basical Medical Sciences Jilin Institute for Veterinary Drug and Feed Control

To predict the three-dimensional structure and binding site of ligand based on amino acidsequence of peroxisome proliferator-activated receptor gamma(PPARγ),transcript variant1 *** secondary structure and surface properties of PPARγtranscript variant 1 Proteinsuch as hydrophilicity,physical and chemical properties,surface probability,flexibleregions,trans–membrane domain,signal peptide and secondary structure were analyzedto predict its binding site of ligand by bioinformatics methods and *** threedimensionalstructure was obtained by submitting amino acid sequence to the *** potential bingding site of ligand were ***:The secondarystructure and bingding site of ligand of PPARγtranscript variant 1 Protein were predictedsuccessfully by *** study provided a foundation for identificationof its advantage binding site of ligand and understanding its biological functions on thebasis of protein structure.

关键词： PPARγ transcript variant 1 protein binding site

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Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5

Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Zhe Zhang Tianlong Zhang Fang Yu Xu-qiao Chen Haixiang Shi Lan Bao Zhou Gong Chun Tang Shanshan Wang Jing Feng Jiangye Chen Jianping Ding State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences State Key Laboratory of Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences

Rabex-5 and Rabaptin-5 function together to activate Rab5 and further promote early endosomal fusion in *** Rabex-5 GEF activity is autoinhibited by the Rabex-5 CC domain(Rabex-5CC)and activated by the Rabaptin-5 C2-1 domain(Rabaptin-5C21)with yet unknown *** report here the crystal structures of Rabex-5 in complex with the dimeric Rabaptin-5C21(Rabaptin-5C212)and in

关键词： Rab Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5 domain GEF

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An Integrated Quantitative Proteomics Approach for Systemsbiologyof Protein Post-translational Modifications(PTM)

An Integrated Quantitative Proteomics Approach for Systemsbi...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Zhongyi Cheng Tongji University

The pathway of protein post-translational modification(PTM) play a crucial role in variouspathophysiological conditions, indicating the promising target for personalized *** substrates of PTM regulative enzymes and their specific inhibitors including HDAC,HMT, kinase and E3 ligase are well demonstrated as effective anti-cancer drugs, while howto comprehensively screen the biomarker and targets of those enzymes and correspondinginhibitors remains great challenges. Using mass spectrometer-based high throughputquantitative proteomics in combination with the advantages of high quality PTM pan antibodiesas well as the intensive bioinformatic analysis, the profiling of acylomics in responseto enzyme activities and the specific inhibitor treatment was comprehensively delineated,generating the largest acetylomics data in eukaryotic cells and prokaryotic cells to *** integrated quantitative proteomics approach therefore provides an effective tool toidentify the PTM-based biomarkers and drug targets in biomedical and pharmaceuticalpre-clinic studies.

关键词： Protein post-translational modification quantitative proteomics acetylomeb iomarker drug targets

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