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检索条件"任意字段=中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议"

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Small heat shock protein IbpB acts as a robust chaperone in living cells by hierarchically activating its multi-type substrate-binding residues

Small heat shock protein IbpB acts as a robust chaperone in ...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：付新苗石小东昌增益北京大学生命科学学院徐州医学院

Small heat shock proteins(sHSPs),as ubiquitous molecular chaperones,are crucial for *** is not clear why sHSPs are able to bind a wide spectrum of non-nativesubstrate proteins and how such binding is enhanced by heat ***,by utilizing agenetically incorporated photo-crosslinker(Bpa),we systematically characterized the substrate-binding residues in IbpB(a sHSP from Escherichia coli)in living cells over a widespectrum of temperatures(from 20oC to 50oC).A total of 20 and 48 residues were respectivelyidentified at normal and heat shock *** are not necessarily hydrophobicand can be classified into three types:type I and II are respectively activated atlow and normal temperatures;type III mediate oligomerization at low temperature butswitch to substrate-binding at heat shock *** addition,substrate-binding ofIbpB in living cells begins at such a low temperature as 25oC and is further enhanced upontemperature ***,these in vivo data provide novel structural insights intothe wide substrate spectrum of sHSP and suggest that sHSP is able to hierarchically activateits multi-type substrate-binding residues and thus act as a robust chaperone in cellsunder fluctuating growth conditionsReference.

关键词： molecular chaperone small heat shock protein unnatural amino acid photocrosslinking

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Characterize the interactions essential for SIVrcm Vpx-mediated DCAF1/DDB1/Cul4-dependent degradation of red-capped mangabey SAMHD1

Characterize the interactions essential for SIVrcm Vpx-media...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Jian Li Fei Guo Chen Liang Institute of Pathogen Biology Chinese Academy of Medical Sciences and Peking Union Medical College

SAMHD1 inhibits HIV-1 infection of myeloid cells and resting CD4+T ***-2 andsome SIV strains,but not HIV-1,carry a SAMHD1 antagonist called *** recognizesSAMHD1 and recruits the ubiquitin E3 ligase complex CUL4/DDB1/DCAF1 that polyubiquitinatesSAMHD1 followed by proteasomal *** lineages of primate lentivirusescarry Vpx,they are the sooty mangabey SIV(SIVsm)/macaque SIV(SIVmac)/HIV-2lineage and the red-capped mangabey SIV(SIVrcm)*** opposed to the wellcharacterizedinteraction of human SAMHD1,SIVmac Vpx and CUL4/DDB1/DCAF1,SIVrcmVpx adopts a different mode of interaction with SAMHD1 of red-capped *** determined that the 23-WLHR-26 peptide of SIVrcm Vpx is essential for recognizingrcm *** larmodelofthercm SAM-HD1-NtD/Vpxrcm/DCAF1-CtD complex,which reveals a likely much greater interface andmore complex interactions between rcmSAMHD1-NtD and Vpxrcm,as compared to humanSAMHD1-CtD and Vpxsm.

关键词： SAMHD1 SIV Vpx

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Structural Basis for Hydroxymethylcytosine Recognition by the SRADomain of UHRF2

Structural Basis for Hydroxymethylcytosine Recognition by th...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Na Yang Ting Zhou Jun Xiong Mingzhu Wang Jiemin Wong Bing Zhu Rui-Ming Xu Institute of Biophysics Chinese Academy of Sciences National Institute of Biological Sciences East China Normal University

Methylated cytosine of CpG dinucleotides in vertebrates may be oxidized by Tet proteins,a process that can lead to DNA demethylation. The predominant oxidation product, 5-hydroxymethylcytosine(5hmC), has been implicated in embryogenesis, cell differentiation,and human diseases. Recently, the SRA domain of UHRF2(UHRF2-SRA) has been reportedto specifically recognize 5hmC, but how UHRF2 recognizes this modification is *** we report the structure of UHRF2-SRA in complex with a 5hmC-containing DNA. Thestructure reveals that the conformation of a phenylalanine allows the formation of an optimal5 hmC binding pocket, and a hydrogen bond between the hydroxyl group of 5hmCand UHRF2-SRA is critical for their preferential binding. Further structural and biochemical analyses unveiled the role of SRA domains as a versatile reader of modified DNA, and the knowledge should facilitate further understanding of the biological function of UHRF2 and the comprehension of DNA hydroxymethylation in general.

关键词： DNA hydroxymethylation SRA domain 5hmC recognition Epigentic regulation

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Synthesis of a Biotinylated Probe for Scutellarein with Anti-Tumor Activity

Synthesis of a Biotinylated Probe for Scutellarein with Anti...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Bin He Sun Zhang Min Wang Xiaoyan Liu Jun Cui Yan Li Guiyang Medical University

Traditional Chinese Medicines(TCMs) have been used clinically in treating many humandiseases for a long period, which are regarded as potential sources for drug ***(or Scutellarein-7-O-glucuronide), A clinic natural drug consisting of totalflavonoids of Erigeron breviscapus(Vant.) Hand-Mazz.(Compositae), has been used for thetreatment of cerebral infarction, coronary heart disease, angina pectoris and other cardiocerebrovasculardiseases in China. Besides, recent study shows that Scutellarin diminishedthe proliferation of B-lymphoma Namalwa cells in vitro and inhibited lymphomagrowth in Namalwa cell-xenotransplanted mice without obvious *** to the significance of scutellarin in the clinical therapy, Scutellarin has been attractedmore and more attentions in recent years. Therefore, we come up two interesting questionsto ask: What's the mechanism of Scutellarin in treating cancer? Howcan we developbetter compounds for treating cancer based on the scaffold of Scutellarin?To address these two questions, we design and synthesize a biotinylated probe of *** further demonstrate that this probe as an analogue of Scutellarin shows similaranti-tumor activity, which can be used as a tool to study on direct targets of Scutellarin incancer treatment.

关键词： Scutellarin Scutellarein Flavonoid Anti-Tumor Biotinylated Probe

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Expression and prognostic significance of CK2α and Survivin inhuman ovarian epithelial tumors

Expression and prognostic significance of CK2α and Survivin...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：刘超刘乙蒙吴爽张晓玉肖建英辽宁医学院

Objective To study the expression of CK2αand Survivin in ovarian tumors,and toanalyze the correlation between CK2αor Survivin and MMP-2/*** further exploretheir relationship with tumor invasion and *** Surgical specimens in paraffinof 13 cases of simple ovarian cysts,13 cases of ovarian benign tumor and 38 cases ofovarian cancer tissue samples,and 10 cases of normal ovarian tissue were collected fromthe First Affiliated Hospital of Liaoning Medical *** expression levels of CK2α,Survivin and MMP-2/MMP-9 were detected with immunohistochemical SP *** expression levels of CK2αand Survivin protein in ovarian cancer were significantlyhigher than those in simple ovarian cysts and ovarian benign tumor(P<0.01).The expressionof CK2αand Survivin protein was correlated with histological grade and clinicalstage(P<0.05).The expression of CK2αor Survivin was positive correlated with that ofMMP2/9(P<0.05).Conclusion The upregulation of CK2αor Survivin expression and thecorrelation with MMP-2 or MMP-9 are related to the progression and invasion or metastasisof ovarian *** may become a new therapeutic target for early diagnosis ofovarian cancer.

关键词： CK2α Survivin immunohistochemistry ovarian cancer

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C/EBPβ-regulated Autophagy Facilitates Adipogenesis

C/EBPβ-regulated Autophagy Facilitates Adipogenesis

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Liang Guo Jia-Xin Huang Qi-Qun Tang Key Laboratory of Molecular Medicine the Ministry of Education Department of Biochemistry and Molecular Biology Fudan University Shanghai Medical College

Autophagy is a highly conserved self-digestion pathway involved in various physiologicaland pathophysiological *** studies have implicated a pivotal role of autophagyin adipocyte differentiation,but the molecular mechanism for its role and how it isregulated during this process is not ***,we show that CCAAT/enhancer-bindingproteinβ(C/EBPβ),an important adipogenic factor,is required for the activation of autophagyduring 3T3-L1 adipocyte *** autophagy-related gene Atg4b is identifiedas a de novo target gene of C/EBPβand plays an important role in ***,autophagy is required for the degradation of Klf2 and Klf3,two negative regulators of adipocyte differentiation,which is mediated by the adaptorprotein p62/***,the regulation of autophagy by C/EBPβand the role ofautophagy in Klf2/3 degradation and in adipogenesis are further confirmed in *** data describe a novel function of C/EBPβin regulating autophagy and revealthe mechanism of autophagy during adipocyte *** new insights into themolecular mechanism of adipose tissue development provide a functional pathway withtherapeutic potential against obesity and its related metabolic disorders.

关键词： 3T3-L1 preadipocytes Adipogenesis C/EBPβ Autophagy Atg4b

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杜仲雌雄株转录组测序数据组装及基因功能注释

杜仲雌雄株转录组测序数据组装及基因功能注释

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：赵德刚李岩吕立堂赵丹董璇 Yi Li 贵州大学生命科学学院/农业生物工程研究院山地植物保护与种质创新省部共建教育部重点实验室贵州大学生命科学学院/农业生物工程研究院山地植物资源保护与种质创新省部共建教育部重点实验室贵州大学生命科学学院/农业生物工程研究院山地植物资源保护与种质创新省部共建教育部重点实验室贵州大学生命科学研究院/农业生物工程研究院山地植物资源保护与种质创新省部共建教育部重点实验室 Department of Plant Science University of ConnecticutStorrsCT06269USA

杜仲(Eucommia ulmoides Oliv.)是具有重要开发价值的药用植物和胶原植物,建立转录组数据库对分离关键功能基因、阐明基因表达特性具有重要意义。本研究在杜仲幼果发育时期对雌雄株幼果、叶片、树皮的转录组进行测序,构建了转录组数据库... 详细信息

杜仲(Eucommia ulmoides Oliv.)是具有重要开发价值的药用植物和胶原植物,建立转录组数据库对分离关键功能基因、阐明基因表达特性具有重要意义。本研究在杜仲幼果发育时期对雌雄株幼果、叶片、树皮的转录组进行测序,构建了转录组数据库,获得雌株51,574,000条、雄株52,430,502条Clean Reads数据,分别包含总长度为4,641,660,000nt和4,718,745,180nt序列数据信息;经拼接组装,获得雌株基因信息长达69,461,730nt的423,339个Contig片段,获得雄株基因信息长达94,814,201nt的542,383个Contig片段;对Scaffold进一步拼接,分别获得平均长度为229nt的雌株159,434个Unigene片段和平均长度为231nt的雄株257,298个Unigene片段;共有48761个表达序列标签(EST),以Unigene和NR数据库比对,杜仲雌雄株转录组基因序列与葡萄的同源性最高,为33.8%,其次是蓖麻(11.4%)和杨树(11.2%),与拟南芥的同源性很低,才2.3%;以Unigene和COG数据库比对,可将杜仲转录组Unigene的功能分为25类,根据GO功能可分为生物过程、细胞组分和分子功能3大类55分支;与KEGG数据库比较,杜仲雌雄株转录组数据含有127类代谢通路的基因,包括多种氨基酸生物合成、脂肪酸代谢、糖代谢,尤其是次生物质代谢途径较多,如萜类化合物生物合成、黄酮与黄酮醇生物合成、异喹啉生物碱生物合成、花青素生物合成等。

关键词：杜仲转录组功能基因

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Structural insights into VirB-DNA complexes reveal mechanism oftranscriptional activation of virulence genes

Structural insights into VirB-DNA complexes reveal mechanism...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： xiao xiao pan gao sheng cui 医科院病原所

VirB activates transcription of virulence genesin Shigella flexneri by alleviating heat-stablenucleoid-structuring proteinmediated promoterrepression. VirB is unrelated to the conventionaltranscriptional regulators, but homologous to theplasmid partitioning proteins. We determined thecrystal structures of VirB HTH domain bound bythe cis-acting site containing the inverted repeat,revealing that the VirB-DNA complex is related toParB-ParS-like complexes, presenting an examplethat a ParB-like protein acts exclusively in transcriptional regulation. The HTH domain ofVirB docksDNA major groove and provides multiple contactsto backbone and bases, in which the only specificbase readout is mediated by R167. VirB only recognizes one half site of the inverted repeatscontainingthe most matches to the consensus for VirB *** binding of VirB induces DNA conformationalchanges and introduces a bend at an invariantA-tract segment in thecis-acting site, suggesting arole of DNA remodeling. VirB exhibits positivecooperativity in DNA binding that is contributed bythe C-terminal domain facilitating VirB oligomerization. The isolated HTH domain onlyconfers partialDNA specificity. Additional determinants for sequence specificity may reside in N- or Cterminaldomains. Collectively, our findings support and extend a previously proposed model for relieving heat-stable nucleoid-structuring protein-mediated repression by VirB

关键词： shigella H-NS VirB

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Regulation of host NF-κB signaling pathway by a M. tuberculosissecreted protein interacting with host E3 ubiquitin ligase TRIM27

Regulation of host NF-κB signaling pathway by a M. tubercul...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Cuihua Liu Jing Wang Bingxi Li Institute of Microbiology Chinese Academy of Sciences

Mycobacterium tuberculosis(Mtb) secretes a variety of effector proteins into host cellsduring the infection process. Those secreted proteins could interfere with a variety of hostsignaling pathways to promote the intracellular survival of Mtb. NF-κB signaling pathway iscritical to the regulation of host innate immune response by controlling expression of anumber of immuno-regulatory molecules(e.g., TNF and IL-1β), thus it is frequently modulatedby intracellular pathogens such as Mtb. Here, we demonstrate that the nonpathogenicM. smegmatis over expressing a secreted Mtb protein, which we namedMUIP2, exhibited an increase in bacterial load and suppression of NF-κB signaling activationin macrophages. Further investigation through yeast two-hybrid and Co-Immunoprecipitation assays revealed that MUIP2 interacts with a host E3 ubiquitin ligaseTRIM27. Dual-luciferase reporter assay data demonstrated that TRIM27 could also inhibitNF-κB signaling activation, and this inhibition could be enhanced by the addition ofMUIP2. Collectively, our data suggest that MUIP2 promotes intracellular survival of mycobacteriaby suppressing host NF-κB signaling pathway through interacting with TRIM27.

关键词： M.tuberculosis NF-κB signaling ubiquitin ligase

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Structural insights into Paf1 complex assembly and histone binding

Structural insights into Paf1 complex assembly and histone b...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Xinlei Chu Xiaohong Qin Huisha Xu Lei Li Zheng Wang Fengzhi Li Hao Zhou YuequanShen Jiafu Long Nankai University

The highly conserved Paf1 complex(PAF1C)plays critical roles in RNA polymerase II transcriptionelongation and in the regulation of histone *** has also been implicatedin other diverse cellular activities,including posttranscriptionalevents,embryonic developmentand cell survival and maintenance of embryonic stem cell ***,we reportthe structure of the human Paf1/Leo1 subcomplex within *** overall structurereveals that the Paf1 and Leo1 subunits form a tightly associated heterodimer throughantiparallel beta-sheet *** biochemical experiments indicate that Leo1binds to PAF1C through Paf1 and that the Ctr9 subunit is the key scaffold protein in ***,we show that the Paf1/Leo1 heterodimer is necessary for itsbinding to histone H3,the histone octamer,and nucleosome in *** results shed lighton the PAF1C assembly process and substrate recognition during various PAF1Ccoordinatedhistone modifications.

关键词： Transcription elongation RNA polymerase II Paf1 complex Histone modification

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