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检索条件"任意字段=中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议"

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The Interaction between Hemoglobin and Spectrin was Proved by Hemoglobin Release Test Coupled with SDS-PAGE and MS

The Interaction between Hemoglobin and Spectrin was Proved b...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：刘瑞刚魏春华解彩霞李晓晶安亮苏燕包头医学院生物化学与分子生物学教研室

In this study,electrophoresis release test（ERT）was used to study the interactions betweenhemoglobin（Hb）and other proteins within ***,the fresh normal adult anticoagulatedwhole blood was washed with saline 4-5 times to prepare packed RBCs,whichwere further prepared to erythrocytes suspension and ***,the erythrocytessuspension and hemolysate were electrophoresed on the starch-agarose mixed gelat the same time,and then the band of HbA1,HbA,HbA2 and HbA-HbA2 of erythrocytessample and the corresponding bands of hemolysate sample which were used as control,were cut out from the ***,proteins within the gel were enriched by freeze-thawmethod,then the protein samples were separated by 5–10%***50kD proteinband emerged in all kinds of Hb bands of the erythrocyte samples,but not emergedin the corresponding Hb bands of hemolysate control ***,these50kDbands were analyzed by Q–TOF *** Q–TOF MS results showed that this band wasspectrin,which is the major constituent of the cytoskeletal network underlying the erythrocyteplasma membrane,So we can conclude that Hb have special interactions with spectrinwithin erythrocytes,however,the physiological significance and the relationship with diseasesneed further research.

关键词： Hemoglobin Spectrin Interaction Eectrophoresis release test SDS-PAGE MS

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Reference Gene Selection for Real-Time Quantitative PCR Analysis of the Ovarian Cryopreservation by Vitrification in mice

Reference Gene Selection for Real-Time Quantitative PCR Anal...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： SHAN Yuan-yuan YANG Yan-zhou YAN Bei GAO Yu-jing PEI Xiu-ying Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education Key Laboratory of Reproduction and Genetics in Ningxia Department of Histology and Embryology Ningxia Medical University Ningxia Yinchuan 750004

Ovarian cryopreservation by vitrification is a very effective method for preserving females'fertility during chemotherapy and radiotherapy, and studying of the gene expressionduring ovarian cryopreservation by vitrification is a common method for exploring themechanism of ovarian cryopreservation by vitrification, but most of reference gene lackingtissue-specific stability with real-time quantitative reverse transcription PCR (RT-QPCR), itis one of the most accurate and widely used techniques for expression profiling of ***, in this study, the stability ofABL1, ACTB, CDKN1A, GPER, GAPDH, GUSB,HPRT1, HSP90AB, IPO8, PPIA, RPL30, RPL4, TBP and uPAR were analyzed by GeNorm,NormFinder,BestKeeper, and the Delta CT during on ovarian tissue cryopreserved by vitrificationin *** the studying the stability of reference gene with real-time PCR toensure accurate reference genes were selected for normalizing the gene expression.

关键词： Reference Gene Ovarian Cryopreservation by Vitrification in mice

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A calcineurin and NFAT-dependent pathway is involved in asynuclein-induced degeneration of midbrain dopaminergic neurons

A calcineurin and NFAT-dependent pathway is involved in asyn...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：骆静 Huaibin Cai 北京师范大学

Parkinson’s disease(PD),the most common degenerative movement disorder,is causedby a preferential loss of midbrain dopaminergic(mDA)*** a-synuclein(a-syn)missense and multiplication mutations have been linked to ***,the underlyingintracellular signalling transduction pathways of a-syn-mediated mDA neurodegenerationremain ***,we show that transgenic expression of PD-related human a-syn A53Tmissense mutation promoted calcineurin(CN)activity and the subsequent nuclear translocationof nuclear factor of activated T-cells(NFAT)in mDA neurons.a-syn enhanced thephosphatase activity of CN in both cell-free assays and cell lines transfected with either humanwild-type or A53T ***,over-expression of a-syn A53T mutation significantlyincreased the CN-dependent nuclear import of NFATc3 in the mDA neurons oftransgenic *** importantly,a pharmacological inhibition of CN by cyclosporine A(CsA)ameliorated the a-syn-induced loss of mDA *** findings demonstrate theactive involvement of the CNand NFAT-mediated signalling pathway in the a-synmediateddegeneration of mDA neurons in PD.

关键词： Parkinson Disease calcineurin alpha-synuclein NFAT midbrain A53T transgenic mice

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Reciprocal repression between FOXP3 and NF-γB and theimplication in gastric cancer development

Reciprocal repression between FOXP3 and NF-γB and theimplic...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：郝强第四军医大学药学系生物制药学教研室

Controversial roles of FOXP3 in different cancers have been reported previously, while itsrole in gastric cancer is largely unknown. Here we found that FOXP3 is unexpectedly upregulatedin some gastric cancer cells and remains the tumor suppressor role in gastriccancer in basal condition. Molecularly, FOXP3 functions as a tumor suppressor by upregulatingits target gene p21 and repressing NF-κB activity and its target gene. However, undersevere inflammatory condition, the tumor suppressive role of FOXP3 is *** with basal condition, FOXP3 is insufficient to inhibit the cell proliferation at inflammatoryconditions. Molecularly, the interaction between FOXP3 and NF-κB could driveFOXP3 away from the promoter of its target gene p21. Taken together, we can expect that inflammation and FOXP3 are reciprocal repressive against each other and the net effects indetailed cancer conditions would contribute to the development of gastric cancer.

关键词： FOXP3 NF-κB

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Discovery of Novel Allosteric Inhibitors for D-3-Phosphoglycerate Dehydrogenase

Discovery of Novel Allosteric Inhibitors for D-3-Phosphoglyc...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：刘培王倩刘莹来鲁华北京大学化学院

D-3-Phosphoglycerate dehydrogenase(PHGDH)catalyzes the first critical step in *** recent studies,over expression of PHGDH was found in melanoma1 andbreast cancers2,and PHGDH is critical for the growth and survival of these cancer *** iswell known that cancer cells mainly use glycolytic pathway to support its fast ***,the mechanisms by which metabolic enzymes promote cancers are not well ***,to design inhibitors targeting PHGDH may provide a viable therapeuticapproach to treat cancers,and also may contribute to uncover the role of metabolicenzymes in cancer development though modulate the flux of the glycolytic *** inhibitors showed better properties by providing new binding sites,increasingselectivity,and decreasing drug resistance *** we first predicted possible allostericsites on PHGDH using computational *** potential allosteric sites wereidentified and used in virtual *** compounds with inhibition activities *** best compound,binding to pocket III,showed high inhibition against *** several rounds of‘design–synthesis–bioassay’studies,twenty-nine analogueswere synthesized and preliminary SAR was *** compounds were studied in *** results showed that the AB part plays more important role than the BC *** are in progress.

关键词： PHGDH Metabolic enzymes Virtual screening Allosteric inhibitors Synthesis

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The changes of telomere length of the Culture Human Lymphocytes

The changes of telomere length of the Culture Human Lymphocy...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： ruifeng ruifeng zhang yuefeng guo 中国辐射防护研究院

Objective To investigate the effect of 12C heavy ion irradiation on telomerelength in culture human *** Culture human lymphocyte line Peng-EBVwere exposed to 12C heavy ion at the irradiation doses of 0.1 Gy,0.5 Gy,1.0 Gy,2.0 Gyand the dose rate was 0.3-0.5 Gy/min.,*** cells were collected at 24,48,72 hafter *** DNA was *** telomere length was measured byfluorescence quantitative PCR,in order to estimate time and dose-response of change intelomere length induced by 12C heavy ion irradiation in culture human *** relative telomere length after exposure all significantly increased(except for 0.5,2.0 Gy exposed cells at 24 h);The relative telomere length of 1.0 Gy exposed cells and at72 h post-irradiation all highly significantly increased;1.0 Gy exposed cells entended moreobviously than that were exposed of 0.1 Gy,0.5 Gy and 2.0 Gy;The relative telomerelength of every dose group increased with prolongation of exposure *** 12Cheavy ion irradiation at 0.1,0.5,1.0and 2.0Gy may all result in telomere extension in culturehuman lymphocytes.

关键词： Telomere length 12C Fluorescence quantitative PCR

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The Studies of Anticancer Drug Delivery Function and Molecular Target Validation of A Novel EA Specific Peptide

The Studies of Anticancer Drug Delivery Function and Molecul...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Xiaowen Ma 第四军医大学药学系生物制药学教研室

The incidence of esophageal adenocarcinoma(EA) caused by Barrett's esophagus(BE) isrising at an alarming rate. The tumor targeted therapy become more important as thechemo/radiotherapy resistance of EA. In previous work, we found a hepta-peptide whichhad EA specific binding ability. Whereby, dose this peptide can be used as anticancerdrugs delivery carrier? What is the molecular target of this peptide? Is this molecular targetan EA unique expression marker? And, dose it have some functions on the development ofBE to EA. For these questions, we will explore the anticancer drugs delivery ability of thispeptide by Micro-PET. We will find and validate the molecular target of the peptide byLSCM,Pull-down,IP,2D electrophoresis, MS, RNAi, Gene transfection etc.. We will characterisethe expression profile of this molecular target and it's potential functions on the developmentof BE to EA by tissue microarray, IHC, RNAi or Gene transfecions. These studies willgive more hints for EA tumor targeted therapies and the mechanism studies of BE malignanttransformation to EA.

关键词： Esophageal Adenocarcinoma Tumor Targeted Therapy

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Real-time monitoring in Live cells using infrared spectroscopy

Real-time monitoring in Live cells using infrared spectrosco...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：边迅 Andrew K.L Chan King’s College London Pharm. Science Research Division

Infrared(IR) spectroscopy is widely employed in structure analysis and quantitative analysisof organics. Since it is a labelfree and non-destructive chemical analysis method, it canbe applied to study on live cells. In order to keep the cells alive and not to be contaminatedduring measurement, an ordinary cell culturing flask has been modified such that livecells can be cultured on CaF2 window. However, the major parts of living cells are water,which takes about 70 weight percentages. Since water molecules are the most abundantchromosphere in in the sample, therefore, strong absorption bands of water will interfereon the results. In order to reduce the interference of water absorption bands, the flaskswere standing erect for a while, the water bands became weaker and the cell band appearedapparently. After the measurement, a Trypan blue essay had been *** on the success of measuring live cells, the methods have been applied to trace thechanges in cells. One is to detect the changes in cells after changing the medium with theone without pyruvate;the other is to explore the changes of ATP in cells after addingTyrphostin 9. The results are in keeping with expectation;the changes of ATP level havebeen detected successfully.

关键词： FTIR live cells protein real-time monitoring ATP

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Inhibition of PCSK6 May Play a Protective role in the Synovitis of CIA

Inhibition of PCSK6 May Play a Protective role in the Synovi...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Huiyu Jiang Shandong Medicinal Biotechnology Centre

Objectives:To assess the effect of PCSK6, a proteinase implicated in the proteolytic activity of variousprecursor proteins and involved in the regulation of protein maturation, in synovial fibroblasts(FLS) of ***:Cultured synovial fibroblasts(FLS) from CIA models were treated with anti-PCSK6 siRNAand the proliferation, invasion, migration capacity, secretion of inflammation factors andcell cycle were studied following. Expression of genes related with proliferation, invasion,migration and inflammation was detected by realtime ***:PCSK6-siRNA treatment significantly decreased cell proliferation, invasion and migration inFLS of CIA. ELISA showed obvious decrease of tumor necrosis factor alpha(TNF-),IL-6 andIL-1βsecretion. Flow cytometry revealed a G0/G1 arrest of FLS. Realtime PCR detected obviouschanges of inflammation-associated chemokines CCL7,CXCL9 and IL-26, angiogenesis-associated MMP-9 and NOSTRIN, hypoxia-associated HIF- and TXNDC5, and proliferation-associated C10ORF116 after PCSK6 siRNA ***:Inhibition of PCSK6 may play a protective role in the synovitis of CIA.

关键词： PCSK6 rheumatoid arthritis

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Galangin suppresses proliferation of Hep G2 cells via activating TGF-γreceptors/Smads pathways

Galangin suppresses proliferation of Hep G2 cells via activa...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Yajun Wang Biyun Lin Xv Li Haitao Zhang Jun Wu Xiaoyi Chen Liubo Lan Hui Luo Department of Biochemistry and Molecular Biology Guangdong Medical College Affiliated Hospital of Guangdong Medical College Department of Chemistry Guangdong Medical College

Galangin can suppress the proliferation of HCC cells. In this study, we demonstrated thatgalangin induced autophagy by activating the TGF-βreceptors /Smads pathways. It stimulatedthe increases of TGF-βRI, TGF-βRII,Smad1,Smad2,Smad3 and Smad4, but decreasedthe levels of Smad6 and Smad7 by galangin. Autophagy induced by galangin appeared tobe dependent of the TGF-βreceptors /Smads signaling pathway because the downregulationof Smad4 by its siRNA or inhibition of TGF-βreceptors activation by LY2109761 can block galangin-induced autophagy. The proliferation of HepG2 cells was restored andalleviated the apoptosis induced with galangin by down-regulation of Beclin1,ATG16 L,ATG12 and ***, the findings demonstrated a novel mechanismof how galangin induces autophagy via activating TGF-βreceptors /Smads pathways. Theinduction of autophagy can thus reflect the anti-proliferation effect of galangin in HCCcells.

关键词： galangin autophagy Smad

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