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检索条件"任意字段=中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议"

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Resonance Light Scattering Measurement of DNA by o-Hydroxyphenyl Fluorone

Resonance Light Scattering Measurement of DNA by o-Hydroxyph...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：夏循礼江西中医药大学

Quantitative analysis of nucleic acids is an important area in the chemical analysis and *** are many kinds of methods,such as Spectrophotometry,Fluorimetryand Electrochemical method,to make quantitative analysis for nucleic *** his research on porphyrin compounds congregating with nucleic acid by ResonanceLight Scattering(***)method and applied it to samples analysis in *** then has being widely applied for chemical analysis because of simple experimentalapparatus need and high *** 1996,Huang Chengzhi et al established anew method which is mainly based on the aggregation of dye chromophore in biologicalmacromolecules,which resulting in strong enhancement of resonance light *** Light Scattering Measurement of DNA by O-hydroxyphenyl fluorone(o-HPF)isbased on the enhancement effect of the Resonance Light Scattering(RLS)due to the combinationof o-HPF with *** this paper,a Resonance Light Scattering Method for DNAmeasurement was established by using o-hydroxyphenyl fluorone(ab.o-HPF)as a probereagent and calf thymus DNA as researching *** the TrisHCl buffer solution at pH8.1,the RLS intensity is proportional to the concentration of DNA in the range of 0.02-1.8×10-5 g·*** detection limit is 4.6×10-8 g·*** method is simple,rapid,highaccuracy and has been applied to the determination of DNA concentration with satisfactoryresults.

关键词： o-Hydroxyphenyl fluorone Resonance light scattering DNA measurement

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Construction of irpT deficient Lactococcus lactis using the Cre-loxP recombination system

Construction of irpT deficient Lactococcus lactis using the ...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Duolong Zhu Kai Zhao Guannan Liu Fulu Liu Haijin Xu Xiuming Zhang Yanling Bai Mingqiang Qiao Department of Microbiology College of Life Sciences Nankai University

Lactococcus lactis is used widely in the food industry as a food-grade non-pathogenic *** this study,we constructed potential nisin immune tolerance gene(irpT)deficientstrain(N8△irpT)by Cre-loxP recombination system in *** *** loxP(lox66 andlox71)sites were integrated into the genome at target sites,and the irpT gene was replacedby a chloramphenicol resistance gene(cat)*** recombination betweentwo loxP sites was very efficient when the Cre recombinase was expressed by constructedpG-Cre plasmid,and the irpT-null strains were isolated after removal of the pGCre *** the relationship between irpT gene and nisin immune tolerance of N8 was ***,pMG36eirpT plasmid was constructed and transformed into N8△*** results showed that the irpT gene was successfully knocked out,and the deletion ofirpT could improve nisin immune tolerance of N8 while the covering strain was almostidentical to the wild *** means the ability of immune tolerance of irpT-null strain isenhanced and the titer of nisin could be *** irpT-null strain could be a nisin industrialproduction strain and be used to industrial fermentation.

关键词： Lactococcus lactis irpT Cre-loxP

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Crystal structure of the WOPR-DNA complex and implications for Wor1 function in white-opaque switching of Candida albicans

Crystal structure of the WOPR-DNA complex and implications f...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Shicheng Zhang Tianlong Zhang Minghui Yan Jianping Ding Jiangye Chen SIBCB S IBS.CAS

Wor1 is a master regulator of the white-opaque switching in Candida albicans,an opportunistichuman fungal pathogen,and is associated with its pathogenicity and ***1 contains a conserved DNA-binding region at the N-terminus consisting of twoconserved segments(WOPRa and WOPRb)connected by a non-conserved linker that canbind to specific DNA sequences of the promoter regions and then regulates the ***,we report the crystal structure of the *** Wor1 WOPR segments in complexwith a double-stranded DNA corresponding to one promoter region of *** separated WOPRa and WOPRb are structurally interwound together to form acompact globular domain we term the WOPR *** WOPR domain represents anew conserved fungal specific DNA-binding domain which uses primarily a conserved loopto recognize and interact specifically with a conserved six-base motif of the DNA in bothminor and major *** protein-DNA interactions are essential for WOR1 transcriptionalregulation and white-to-opaque *** structural and biological data togetherreveal the molecular basis for the recognition and binding specificity of the WOPRdomain with its specific DNA sequences and the function of Wor1 in the activation of transcription.

关键词： white-opaque switching protein-DNA recognition transcriptional regulation crystal structure

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MicroRNA-18a suppresses LXRγ expression in human neuroblastoma cells and hepatocytes

MicroRNA-18a suppresses LXRγ expression in human neuroblast...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Dan-Dan Shang Xin Xin Mei Han Hebei Medical University

The liver X receptor α(LXRα, NR1H3) and LXRβ(NR1H2) are members of the nuclear hormonereceptor *** play a critical role in the transcriptional control of lipidmetabolism. MicroRNAs(miRs) are regarded as important negative regulators of gene *** has been reported that miR-1/miR-206 suppress LXRα-induced lipogenesis inhepatocytes. However, the regulation of LXRβ by microRNAs is not fully understood. In thisstudy, we found that miR-18 a repressed LXRβ expression in both human neuroblastomacells and hepatocytes at both mRNA and protein levels. In addition, bioinformatics analysiswith TargetScan and PicTar predicted a putative target-site for miR-18 a located within the3'-untranslated region(3'-UTR) of LXRβ mRNA. To verify our prediction, HEK293 cellswere cotransfected with reporters(pMIR-LXRβ) and miR-18 a mimics. We found that miR-18 a inhibited the luciferase activity of LXRβ 3'-UTR reporter,suggesting that miR-18 adirectly target the 3'-UTR of LXR β mRNA. Taken together, we for the first time demonstrated that miR-18 a repressed LXRβ expression by targeting the 3'-UTR of LXRβ mRNA.

关键词： LXRβ miR-18a

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Immune-regulation and anti-inflammatory effects of isogarcinol extracted from Garcinia mangostana Linn against collagen-inducedarthritis

Immune-regulation and anti-inflammatory effects of isogarcin...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Yanxia Fu Hailing Zhou Mengqi Wang Juren Chen Qun Wei Department of Biochemistry and Molecular Biology Beijing Normal University Gene engineering and Biotechnology Beijing Key Laboratory

Isogarcinol is a natural compound that we extracted from Garcinia mangostana Linn, andwe were the first to report that it is a new immunosuppressant. In the present study, we investigatedthe immune-regulation and anti-inflammatory effects of isogarcinol on collagen-induced arthritis(CIA) and explored its potential mechanism in the treatment ofrheumatoid arthritis. The oral administration of isogarcinol significantly reduced clinicalscores, alleviated cartilage and bone erosion and reduced the levels of serum inflammatorycytokines in CIA mice. Isogarcinol inhibited acetic acid-induced capillary permeability andxylene-induced mouse ear edema in vivo. In vitro, isogarcinol decreased iNOS mRNA transcriptionand NO content in LPS stimulated macrophagocytes by inhibiting NF-κB transcriptionalactivity. Furthermore, isogarcinol decreased the transcriptional activity of NFATand inhibited IL-2 expression. The mechanism of action of isogarcinol is associated withdown-regulation of both autoimmune and inflammatory reactions.

关键词： Garcinia mangostana Linn isogarcinol collagen-induced arthritis inflammation,immunity

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Long non-coding RNAs: New players information of fear memory

Long non-coding RNAs: New players information of fear memory

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：史海水尹希吴红海候艳宁河北医科大学河北医科大学第四医院白求恩国际和平医院

Understanding the mechanisms underlying the formation of memories is a central goal forneuroscientists. Adaption of structural and functional plasticity is the neural basis ofmemory processes. Epigenetic regulation has emerged as important mechanism for synapticplasticity and memory formation. Long non-coding RNA(lncRNA) has no protein-coding ability and can act as epigenetic regulators. The role of lncRNAs in CNS, especiallyin memory processes has not been well-investigated. Using contextual fear conditioningrat model, a custom-designed microarray was applied to examine the expressionprofile of mRNAs and lncRNAs of hippocampal CA1 region during memory formation.1898 mRNAs and 1445 lncRNAs were identified to be significantly differential *** methods(e.g. GO analysis, Pathway analysis and DynamicGeneNet analysis)were used for further function analysis. The genome-wide alteration of lncRNAs expression indicates lncRNAs could be potential regulator for memory formation, which provided new idea for elucidating the epigenetic mechanism of memories.

关键词： Long noncoding RNA Memory Transcriptome Bioinformatics

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Let-7c inhibits metastatic ability of Mouse Hepatocarcinoma Cellsvia targeting glycosyl-transferase Mgat4a

Let-7c inhibits metastatic ability of Mouse Hepatocarcinoma ...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Yanjie Guo Sheng Li Jianhua Qu Shujing Wang Jianhui Fan Jianing Zhang Dalian Medical University Dalian Univeristy of Technology

Aberrant glycosylation may promote tumor invasion and *** investigate whethermicroRNA(miRNA)is involved in glycosylation-related metastasis,we examined the roleof let-7c,a well-known tumor-supressor miRNA,in glycosylation in murine hepatocarcinomacell lines Hca-F and *** found that let-7c level is higher in Hca-P cells(withlow lymphatic metastasis potential)than in Hca-F cells(with high lymphatic metastasis potential).Overexpression of let-7c decreased hyperN-glycosylation of Hca-F cells andrepressed their metastatic and invasive *** acetylglucosaminyltransferase4(Mgat4a)is a key glycosyltransferase in the pathway of synthesizing complex *** and biochemical analyses indicate that Mgat4a is a direct and functionaltarget of *** anti-metastasis effect of overexpressed let-7c is similar to that ofMgat4a ***,our results suggest that let-7c may inhibit the metastatic ability ofHca-F cells,at least partially,via repressing Mgat4a activity.

关键词： miRNA glycosylation metastasis

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Structural Basis for Hydroxymethylcytosine Recognition by the SRADomain of UHRF2

Structural Basis for Hydroxymethylcytosine Recognition by th...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Na Yang Ting Zhou Jun Xiong Mingzhu Wang Jiemin Wong Bing Zhu Rui-Ming Xu Institute of Biophysics Chinese Academy of Sciences National Institute of Biological Sciences East China Normal University

Methylated cytosine of CpG dinucleotides in vertebrates may be oxidized by Tet proteins,a process that can lead to DNA demethylation. The predominant oxidation product, 5-hydroxymethylcytosine(5hmC), has been implicated in embryogenesis, cell differentiation,and human diseases. Recently, the SRA domain of UHRF2(UHRF2-SRA) has been reportedto specifically recognize 5hmC, but how UHRF2 recognizes this modification is *** we report the structure of UHRF2-SRA in complex with a 5hmC-containing DNA. Thestructure reveals that the conformation of a phenylalanine allows the formation of an optimal5 hmC binding pocket, and a hydrogen bond between the hydroxyl group of 5hmCand UHRF2-SRA is critical for their preferential binding. Further structural and biochemical analyses unveiled the role of SRA domains as a versatile reader of modified DNA, and the knowledge should facilitate further understanding of the biological function of UHRF2 and the comprehension of DNA hydroxymethylation in general.

关键词： DNA hydroxymethylation SRA domain 5hmC recognition Epigentic regulation

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Geniposide Regulates Glucose-Stimulated Insulin Secretion Possibly through Controlling Glucose Metabolism in INS-1 Cells

Geniposide Regulates Glucose-Stimulated Insulin Secretion Po...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：郭莉霞 Chongqing Key Laboratory of Catalysis & Functional Organic Molecules Chongqing Technology and Business University

Glucose-stimulated insulin secretion(GSIS) is essential to the control of metabolic fuelhomeostasis. The impairment of GSIS is a key element of β-cell failure and one of causes oftype 2 diabetes mellitus(T2DM). Although the KATP channeldependent mechanism ofGSIS has been broadly accepted for several decades, it does not fully describe the effectsof glucose on insulin secretion. Emerging evidence has suggested that other mechanismsare involved. The present study demonstrated that geniposide enhanced GSIS in responseto the stimulation of low or moderately high concentrations of glucose, and promotedglucose uptake and intracellular ATP levels in INS-1 cells. However, in the presence of ahigh concentration of glucose, geniposide exerted a contrary role on both GSIS and glucoseuptake and metabolism. Furthermore, geniposide improved the impairment of GSIS inINS-1 cells challenged with a high concentration of glucose. Further experiments showedthat geniposide modulated pyruvate carboxylase expression and the production of intermediatesof glucose metabolism. The data collectively suggest that geniposide has potentialto prevent or improve the impairment of insulin secretion in β-cells challenged withhigh concentrations of glucose, likely through pyruvate carboxylase mediated glucosemetabolism in β-cells.

关键词： GSIS geniposide

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The DDX3 protein is a new biomarker for cervical cancer

The DDX3 protein is a new biomarker for cervical cancer

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Yuling Liu Yangmei Shen Bing Chen Xuewen Jin Shufang Liang State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy West China HospitalSichuan University West China Second Hospital Sichuan University

Cervical cancer is the third most common type of cancer among women worldwide. Infectionwith human papilloma virus(HPV) is a main risk factor for developing cervical *** DDX3 protein, a member of the DEAD-box family with RNA helicase and ATPase, is associatedwith multiple biological functions involving in RNA metabolism, virus infection,cancer progression, tumor metastasis and so on. In order to investigate the relationship ofDDX3 expression with HPV-related cervical cancer development, we examined its expressionin surgically excised human cervical cancer specimens. Compared to the correspondingnontumor tissues, the expression of DDX3 in cervical cancer is greatly ***, DDX3 is differentially expressed with the HPV infection and tumor differentiationdegree in cervical carcinoma. The expression level of DDX3 is much downregulatedin the lowly differentiated cervical carcinoma tissues with HPV infection(p<0.05) than themoderately or highly differentiated tumor samples. DDX3 is a potentially novel diagnosticbiomarker for cervical cancer.

关键词： Cervical cancer human papillomavirus(HPV) DDX3

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