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检索条件"任意字段=中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议"

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Decreased expression of nicotinic acetylcholine receptor in the hippocampus of vascular dementia rats and in blood leukocytes from Chinese patients with vascular dementia

Decreased expression of nicotinic acetylcholine receptor in ...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：肖雁 Hang Jing Mao Tan Yan-jun Dong Xiao-lan Qi Zhi-zhong Guan 贵阳医学院分子生物学重点实验室贵阳医学院研究生院贵阳医学院分子生物学重点实验室病理教研室

In order to investigate the cholinergic deficit in Vascular dementia(VaD),fifty-nine Chinesepatients with VaD and thirty-onecases as the age-matched controls in China were selectedand to establish the similar animal model of vascular dementia(VaD)Pulsinelli’s fourvesselocclusion,to nurture the VaD rats,and Morris water maze experiment is used to testthe cognition abilityof the *** mRNA levels ofα4 andβ2 nicotinic acetylcholine receptor(nAChR)subunits in blood leukocytes of patientandβ2,α4,α7nAChR subunits inhippocampus of rats were analyzed by Real-Time PCR,the protein level ofβ2,α4,α7nAChRsubunit in the hippocampus of rats were analyzed by western *** results showedthat mRNA levels ofα4 nAChRsubunit in blood leukocytes was significantly lower in VaDgroup than that in controls,mRNA levels ofβ2,α7 nAChR subuniin the hippocampus wassignificantly lower in VaD group than that in controls in rats,respectively,the mRNA levelof thesubunit ofα4 increased;The expression of theβ2,α4,α7 nAChR subunit protein wassignificantly *** resultindicated that the decreases in the mRNA levels of nAChRα4 subunit from the peripheral blood of the patients with VaDmight serve as supplementaryindicators for the clinical diagnosis of *** decrease of nAChR of hippocampusneuronscan possibly be the foundation of the injury of the cognition function of theVaD rats.

关键词： learning and memory Nicotinic acetylcholine receptor Vascular dementia A nimals model

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Effects of Scutellarin against neurotoxicity induced by betaamyloidpeptide in human SH-SY5Y neuroblastama cells

Effects of Scutellarin against neurotoxicity induced by beta...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：邓婕齐晓岚官志忠贵阳医学院医学分子生物学重点实验室贵阳医学院研究生院

Scutellarin(Scu) is the major active principle extracted from Herba Erigerontis(HE), aChinese herbal medicine derived from Erigeron breviscapus. The study is designed to investigatethe effects of Scu on the expression of nicotinic acetylcholine receptors(nAChRs),the level of lipid peroxidation, the rate of apoptosis induced by beta-amyloid peptide(Aβ)in human neuroblastoma SH-SY5 Y cells. SH-SY5 Y cells were treated with Scu and then exposedto Aβ25-35. MTT(3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide)reduction was measured by spectrophotometric analysis;the α3 and α7 nAChRs subunitsat protein level by Western blotting;lipid peroxidation(MDA) by TBARS;the activity of superoxidedismutase(SOD) by the method of Xanthine oxidase and the rate of apoptosis byflow cytometry. The results showed that the treatment of Scu increased expression of α7and α3 nAChR subunit proteins in the cultured cells. When the cultured cells were exposedto Aβ25-35, the declined MTT reduction, the increased levels of oxidative stress and apoptosis,andthe inhibited expression of α3 and α7 nAChR subunit proteins were ***, the treatment with Scu prior to Aβ prevented these neurotoxic effects resultingfrom Aβ. The results therefore indicate that Scu extracted from HE may have a neuroprotectiverole against Aβ toxicity, which might imply a potential therapeutic effect inAlzheimer's disease.

关键词： Herba Erigerontis SH-SY5Y cells Nicotinic acetylcholine receptor β-amyloidp eptide

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Single-Cell Protein-Protein Interaction Study

Single-Cell Protein-Protein Interaction Study

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： LinaLina Wu Xu Wang Tian Luan Xiaomei Yan 厦门大学化学化工学院

Protein–protein interactions are fundamental to virtually every aspect of cellular *** and characterization of protein interactions have therefore become a majorobjective of postgenome *** bacterial two-hybrid(B2H)system is a powerfultechnology to study protein-protein interactions.[1]On the other hand,single-cell analysisis vital for revealing population heterogeneity and rear events that have been masked byensemble *** the strength of protein-protein interaction is determinednot only by the binding affinity but also by the concentrations of the hybrid proteinpairs,it is therefore valuable to assess protein expression side by side with protein-proteininteraction ***,the vectors of the tradition B2H system are not designedto enable easy detection of recombinant protein *** overall goal of thisproject is to develop a new method for studying protein-protein interaction within individualbacterial cells by combining ultra-sensitive flow cytometry with bacterial *** constructed New B2H vectors by inserting Flag tag and His tag into the baitand prey vectors,*** a laboratory-built high-sensitivity flow cytometer(HSFCM)[2]together with dual immunofluorescence staining,it is possible to perform aquantitative and simultaneous measurement of protein expression and protein-protein interactionwithin individual *** new method will be used to map a series of interactingprotein pairs with different affinities,from which the relationship between thestrength of pairwise interactions and the expression of the reporter gene can be *** method is not only simple,fast,and sensitive but also provides simultaneousquantification of the protein pairs at the single bacterial level.

关键词： Protein-protein interaction Bacterial two-hybrid system Flow cytometry Protein expression

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The functional and structure study of phosphatidylinositol 4-kinase IIalpha

The functional and structure study of phosphatidylinositol 4...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：陈畅中国科学院生物物理研究所

Phosphatidylinositol(PI)4-kinase IIα(PI4KIIα)is the dominant PI4K in mammalian cells andplays important roles in membrane trafficking and signaling *** report forthe first time that PI4KIIαcan promote the growth of multimalignant tumors[1].Our furtherstudy showed that PI4KIIαhas pivotal role in the regulation of EGFR protein levels andcombinatorial inhibition of PI4KIIαand EGFR showed strong anti-tumor effect[2].To knowthe kinase activity regulation mechanism,we then solved the crystal structure of humanPI4KIIαcatalytic domain in its ADP-bound form at *** novel insertionsthat are not present in other PIKs were found in PI4KIIα.The palmitoylation insertion andRK-rich insertion are critical for the regulation of PI4KIIα’s membrane binding and kinaseactivity.A distinct nucleotidebinding pocket of PI4KIIαwas found that differs notablyfrom that of PI3Ks,which well explained the insensitivity of PI4KIIαto PI3Ks’*** dynamics stimulation,biochemical and mutagenesis studies reveal that any perturbationof the interaction between PI4KIIαand membrane will affect either the nucleotidebinding or PI binding and then modulate the kinase activity of PI4KIIα[3].Screeningfor a subtype specific inhibitor for PI4KIIαis undergoing.

关键词： phosphatidylinositol 4-kinase IIalpha functional structure

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The RanGTP-modulation of Mog1 is required for faithful mitotic chromosome segregation

The RanGTP-modulation of Mog1 is required for faithful mitot...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：刘恒中国科技大学

The role of the small GTPase Ran in spindle assembly has been recently uncovered to ensurethe correct chromosome segregation and thus genetic stability in mammalian *** Mog1,as the Ran nucleotide release factor,can downregulate RanGTP in vitro,but the underlying molecular mechanism for Mog1 modulating the function of Ran *** Ran crystal structure has been solved,the structural characterizationof the Mog1/Ran complex remains a challenge due to the dynamic nature of their *** is particularly suited to elucidate the structure and dynamics of proteincomplexes even there are conformational ***,therefore,solved the solutionstructure of human Mog1(hMog1)at *** overcome the NMR size limitation,we recruitedthe methyl-TROSY based NMR approaches,e.g.,intra-molecular methyl NOEs andsite-directed mutations for the complex methyl chemical shift assignment,and intermolecularmethyl NOEs,Paramagnetic relaxation enhancement(PRE),Residual dipolarcouplings(RDCs)to generate the structural model of hMog1/Ran *** structuralmodel indicated interfacial residues crucial for the GTP/GDP releasing from Ran catalyzedby Mog1,such loss-of-function mutations were thereafter validated by in vitro binding andenzymatic ***,the depletion and overexpression of Mog1 induced defectsin mitotic chromosomes alignment in living cells,while the loss-of-function mutants *** the RanGTP gradient was also disrupted due to the aberrant hMog1 level usingRango2 ***,we conclude that hMog1 plays an important role in mitotic chromosomesegregation by regulating the RanGTP level.

关键词： RanGTP mitosis

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Intramolecular Regulation of the WW Domain of HYPB/SETD2 for Its Sequestration by the Huntingtin Aggregates

Intramolecular Regulation of the WW Domain of HYPB/SETD2 for...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Yong-Guang Gao Hui Yang Jian Zhao Ya-Jun Jiang Hong-Yu Hu State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology SIBS CAS

Huntington's disease(HD)is a progressive neurodegenerative disorder caused by thepolyglutamine(polyQ)expansion in huntingtin(Htt)protein,a ubiquitously expressed proteinof yet unknown *** its public health importance,it is striking that thepathogenesis of HD is not well ***,how Htt aggregates affect thephysiological processes of its effector proteins are largely unknown and this is one of thecentral questions about the pathology of *** yeast two-hybrid protein B(HYPB/SETD2)is a histone methyltransferase directly interacting with Htt and is involved in HD *** this work,we found that a majority of the WW domain in HYPB was intramolecularlly inhibitedby a polyproline(polyP)stretch *** solved the solution structure of the inhibitedWW domain and found that the polyP stretch extends from the back binding tothe WW core domain in a typical binding *** also found that this polyP stretchsignificantlyregulates the interaction of the WW domain of HYPB with the proline-rich region(PRR)of ***,sequestration of the WW domain of HYPB by the Htt aggregateswas orchestrated by the PolyP stretch in cell *** is the first evidence indicatingthat the interactions of Htt with its effector proteins are regulated,which provides anopportunity for therapeutic *** study gains structural and mechanistic insightsinto the intramolecular regulation of the WW domain in HYPB for interacting withHtt and the sequestration of HYPB by the Htt aggregates,which will contribute to our understandingof the pathology of HD.

关键词： Huntingtin HYPB/SETD2 Intramolecular interaction Aggregate Sequestration Proline-rich region WW domain

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Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis

Structure of pneumococcal peptidoglycan hydrolase LytB revea...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：陈慧杰柏晓辉张敬仁陈宇星周丛照中国科学技术大学清华大学

Streptococcus pneumoniae causes a series of devastating infections in *** have shown that the endo-β-N-acetylglucosaminidase LytB is critical for pneumococcalcell division and nasal colonization,but the biochemical mechanism of LytB actionremains *** we report the 1.65 ? crystal structure of the catalytic domain(residues Lys375-Asp658)of LytB(termed LytBCAT),excluding the choline-binding *** consists of three structurally independent modules:SH3b,WW and *** form a"T-shaped"pocket that accommodates a putative tetrasaccharide-pentapeptide substrate of peptidoglycan(PGN).Structural comparison and simulationrevealed that the GH73module of LytB harbors the active site,including the catalyticresidue *** vitro assays of hydrolytic activity indicated that LytB prefers the peptidoglycanfrom the lytB-deficient pneumococci,suggesting the existence of specific substrateof LytB in the immature *** with in vitro cell-dispersing and in vivo cellseparationassays,we demonstrated that all three modules are necessary for the optimalactivity of *** functional analysis showed that the full catalytic activity of LytB isrequired for pneumococcal adhesion to and invasion into human lung epithelial ***-based alignment indicated that the unique modular organization of LytB ishighly conserved in its orthologs from Streptococcus mitis group and Gemella *** findings provided structural insights into the pneumococcal cell wall remodelingand novel hints for the rational design of therapeutic agents against pneumococcal growthand thereby the related diseases.

关键词： Streptococcus pneumoniae cell wall remodeling peptidoglycan crystal structure pathogenesis

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Oxidative stress is an important factor triggering the aggregation of cataract-causing γ-crystallin mutants

Oxidative stress is an important factor triggering the aggre...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：赵维杰闫永彬 State Key Laboratory of Biomembrane and Membrane Biotechnology School of Life Sciences Tsinghua University

Crystallins are the major structural proteins in mammalian lens and their stability is essentialfor the lens to maintain transparency throughout one individual’s *** normallens,the crystallins are protected from oxidization by the high concentration of glutathione(GSH)within the *** in the case of aging cataract lens,the GSH concentrationis decreased and proteins including crystallins undergo oxidization and lose the abilityto maintain stable and *** that many cataract-causing mutations are substituted by oxidable residues,here we asked whether oxidization plays a role in the onset of congenital *** was addressed by studying the behaviors ofγC andγD crystallin and variouscataract-causing mutatants under oxidative *** results showed that under oxidativestress,theγD mutants R14C and G60C formed dimer via intermolecular disulfidebond,while the WTγD and the mutant R58H didn’*** proteins showed decreasedthermo stability and the impairment was ever serious.R58H showed no significant differencewith WT protein in thermo stability in absence of oxidization,while became lessstable than WT after *** further found that theγC proteins were more sensitiveto oxidization thenγD *** the WT and mutated proteins were crosslinkedafter *** the cataract-causing mutants exhibited a much lower thermo stabilitythan the WT *** results suggested that the cataract-causing mutations significantlyincreased the sensitivity to oxidative *** might be an importantfactors involved in the progression of congenital cataract caused by inherited mutations.

关键词： Crystallin oxidative stress cataract

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pp-GalNAc-T6 modulates the biological functions of breast cancercell MCF-7

pp-GalNAc-T6 modulates the biological functions of breast ca...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Jun Ren Yanxing Wang Manman Bian Jianxin Lu Xiaoming Chen School of Laboratory Medicine & Life Science Wenzhou Medical University

pp-GalNAc-T6(GALNT6) one of the large enzyme family of UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosam inyltransferases(ppGalNAc-Ts), which catalyzes the initial step in the biosynthesis of mucin-type O-glycan by transferring GalNAc from UDP-GalNAc to the Ser and Thr residue of polypeptide acceptors. It has been reported to be involved in breast tumor, but the role of GALNT6 in the biological characters of breast cancer is not well understood. In this study, we found the lower expression of GALNT6 in MCF-7 cells decreased cell proliferation and migration, whereas over expression GALNT6 increased them. And the expression of Mucin protein 1(MUC1), matrix metall oproteinases-2(MMP-2) and matrix metalloproteinases-9(MMP-9), is positively correlated with the expression ofGALNT6. The expression of E-cadherin was increased in the lower expression of GALNT6 inMCF-7 cells. These results suggest that the effects of GALNT6 on proliferation, invasion and migration of MCF-7 may be through affecting the MMPs and E-cadherin. Taken together,our findings indicate that GALNT6 plays a role in cell proliferation, migration and invasion in breast cancer, and provide molecular evidence of a new adjuvant strategy for therapy of breast cancer.

关键词： pp-GalNAc-T6 O-glycan breast cancer

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Isolation of an antifungal pathogenesis-related protein from nakedoat(Avena nuda) seeds

Isolation of an antifungal pathogenesis-related protein from...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：刘健石亚伟韩德平任页玫 Institute of Biotechnology Key Laboratory of Chemical Biology and Molecular Engineering of Ministry Of Education Shanxi University

Thaumatin-like proteins(TLPs) are the products of a large, highly complex gene family involvedin host defence and belong to the pathogenesis-related family(PR-5) of plant defenseproteins. Most TLPs exhibit potential antifugal activities and theiraccumulation inthe plant is related to many physiological *** this paper a novel antifungal proteinwas isolated from naked oat(Avena nuda) seeds by a procedure involving acetonefractionation,(NH4)2SO4 precipitation, Q-Sepharose ion exchange chromatography, chitinaffinity chromatography and Sephacryl S-200,identified by matrix-assisted laser desorptionionization–time of flight mass spectrometry analysis. The antifungal activity of thisprotein was detected by methed of Sterile Oxford cups and observed by Delta Vision *** results showed that the protein isolated from naked oat seeds exhibited a molecularmass of 23,760 Da in gel filtration and SDS-PAGE, which is homology with thaumatin-likeand pathogenesis-related proteins of the PRP-5 family. The protein also exhibited antifungalactivity against Trametes sp. SQ01(IC50=5.68 μM), Trichoderma spp.(IC50=0.83μM) by inducing mycelium deformation, rupture, and protoplasm lysis.

关键词： Permatin Thaumatin-like protein Purification Antifungal Avena nuda

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