检索结果-内蒙古大学图书馆

您好，读者！请登录

内蒙古大学图书馆

首页
概况
党建
资源
服务
科研支持
- 论文收录引用证明
- 科技查新
知识产权
档案馆
帮助

咨询与建议

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

您的常用邮箱：*

您的手机号码：*

问题描述：

当前已输入0个字，您还可以输入200个字

全部搜索
期刊论文
图书
学位论文
标准
纸本馆藏
外文资源发现
数据库导航
超星发现

高级检索

时间限定

出版年份：

文献类型

图书期刊文献学位论文多媒体

馆藏选择

电子馆藏纸本馆藏

核心期刊

全部期刊 SCI 收录期刊 SSCI 收录期刊 EI 收录期刊 CSCD 收录期刊 CSSCI 收录期刊

语言

中文英文

文献类型

期刊文献图书学位论文标准纸本馆藏

帮助

文字说明：

T=题名（书名、题名），A=作者（责任者），K=主题词，P=出版物名称，PU=出版社名称，O=机构（作者单位、学位授予单位、专利申请人），L=中图分类号，C=学科分类号，U=全部字段，Y=年（出版发行年、学位年度、标准发布年）

检索规则说明：

AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：

范例一：(K=图书馆学 OR K=情报学) AND A=范并思 AND Y=1982-2016
范例二：P=计算机应用与软件 AND (U=C++ OR U=Basic) NOT K=Visual AND Y=2011-2016

分类表

所选分类

>> <<

限定检索结果

文献类型

581 篇 会议
4 篇 期刊文献

馆藏范围

585 篇 电子文献
0 种 纸本馆藏

日期分布

学科分类号

285 篇 医学
- 156 篇 临床医学
- 84 篇 基础医学(可授医学...
- 37 篇 中西医结合
- 32 篇 药学(可授医学、理...
- 21 篇 中药学(可授医学、...
- 2 篇 公共卫生与预防医...
- 2 篇 医学技术（可授医学...
248 篇 理学
- 246 篇 生物学
- 2 篇 物理学
- 1 篇 生态学
174 篇 工学
- 141 篇 化学工程与技术
- 25 篇 生物工程
- 2 篇 机械工程
- 2 篇 材料科学与工程（可...
- 2 篇 电子科学与技术（可...
- 2 篇 食品科学与工程（可...
- 1 篇 力学（可授工学、理...
- 1 篇 计算机科学与技术...
- 1 篇 纺织科学与工程
- 1 篇 轻工技术与工程
- 1 篇 农业工程
- 1 篇 林业工程
- 1 篇 生物医学工程（可授...
- 1 篇 公安技术
75 篇 农学
- 58 篇 作物学
- 10 篇 畜牧学
- 4 篇 水产
- 1 篇 农业资源与环境
- 1 篇 植物保护
13 篇 教育学
- 13 篇 教育学

主题

11 篇 dna
4 篇 会员代表大会
4 篇 中国生物化学与分...
4 篇 domain
4 篇 lncrna
4 篇 学术会议
4 篇 rna
3 篇 lncrnas β-thalas...
3 篇 国际会议中心
3 篇 领域专家
3 篇 生物化学
3 篇 signaling
3 篇 2型糖尿病
3 篇 sm22α
3 篇 disease
3 篇 interaction
3 篇 厦门市
3 篇 pbl
3 篇 autophagy
3 篇 protein

机构

14 篇 北京大学
11 篇 山东大学
11 篇 厦门大学
10 篇 清华大学
9 篇 复旦大学
7 篇 key laboratory o...
7 篇 peking universit...
7 篇 中国科学技术大学
6 篇 第四军医大学
6 篇 institute of bio...
6 篇 武汉大学
6 篇 浙江大学
5 篇 江西中医药大学
5 篇 school of life s...
5 篇 xiamen universit...
5 篇 department of bi...
5 篇 河北医科大学
4 篇 institute of bio...
4 篇 school of pharma...
4 篇 军事医学科学院放...

作者

8 篇 孙金鹏
7 篇 zhihua wu
7 篇 donghai lin
7 篇 xiaofeng zheng
7 篇 qun wei
6 篇 周丛照
6 篇 youxin jin
6 篇 zhongyi cheng
6 篇 闫永彬
5 篇 botao zhao
5 篇 weining niu
5 篇 qi-qun tang
5 篇 yan jin
5 篇 detao wang
5 篇 sen liu
4 篇 mei han
4 篇 shufang liang
4 篇 jiali wei
4 篇 yue zhao
4 篇 rui yang

语言

521 篇 英文
64 篇 中文

检索条件"任意字段=中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议"

共 585 条记录，以下是351-360 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Effects of UV-B Radiation on Light Signal Transduction in Wheat

Effects of UV-B Radiation on Light Signal Transduction in Wh...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：段江燕贾震虎山西师范大学生命科学学院

In order to understand the effects of UV-B radiation on the signal transduction pathway ofwheat, wheat seedlings of Jinmai 8 were treated with different doses(10KJ.m-2.d-1,12 KJ.m-2.d-1, 14 KJ.m-2.d-1) of UV-B radiation. Then several antagonist such as CaM antagonists,G-protein activator, Ca2+ antagonists, serine / threonine protein kinase were addedto analyze the changes in the components of light signal transduction. By fluorescencespectroscopy and northern blotting analysis, the results showed that CaM, G-proteins,Ca2+, a serine / threonine protein kinase, anthocyanin were involved in the transmission oflight signaling pathway of UV-B radiation-induced wheat;Low doses and high doses ofUV-B radiation induced different signaling pathway to product anthocyanin;10 KJ.m-2.d-1,12 KJ.m-2.d-1 doses of UV-B radiation induced the expression of chalcone synthase(CHS) gene, while 14 KJ.m-2.d-1 doses of UV-B radiation inhibited its gene ***, it was concluded that low doses and high doses of UV-B radiation resulted intwo different signaling pathways for regulation of plant physiology and biochemistry.

关键词： Wheat UV-B radiation Light signal pathway

来源：评论

学校读者我要写书评

暂无评论

Metabolic flux changes characterization of *** K12 W3100 exposed to hydrogen peroxide induced oxidative stress

Metabolic flux changes characterization of *** K12 W3100 exp...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Yu Lv Yunyu Shi University of Scicence and Technology of China University of Science and Technology of China

Reactive oxygen species(ROS) are by-product of aerobic cellular metabolism which includesuperoxide anion radical(O2-), hydrogen peroxide(H2O2), and the highly reactivehydroxyl radicals(.OH), etc. Metabolically generated H2O2 which occurs at about 10 nM intracellularconcentration emerged from recent research as a central hub in redox signalingand oxidative stress. Metabolic Flux Analysis(MFA) which is an important method for thequantitative estimation of intracellular metabolic flows through metabolic pathways andthe elucidation of cellular physiology and allows the detailed quantification of all intracellularfluxes of our interest in microorganism was employed as a key tool to investigate theimpact of H2O2 to the whole picture of central metabolism of the prototrophic, genetictractable and well-defined strain *** K12 W3100. We found that several key steps *** central metabolism including the reaction from G6 P to Ru5 P in pentose phosphatepathway and OAA to PYR in anaplerotic reaction pathway may be influenced by hydrogenperoxide in a direct or indirect manner in the form of stable flux redistribution between thewild type and hydrogen peroxide treated one. Some basic conclusions about strategies thecell takes to antagonize the oxidative stress and evolution robustness of the complex pathwayscan be drawn.

关键词： metabolic flux analysi oxidative stress hydrogen peroxide

来源：评论

学校读者我要写书评

暂无评论

The activation mechanism of STING-dependent interferon responses to intracellular DNA in antiviral innate immune signaling pathway

The activation mechanism of STING-dependent interferon respo...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：欧阳松应刘志杰中国科学院生物物理研究所

The innate immune response is the first line of defense initiated against the *** receptors,contained on the surface or within the cell,named pattern recognitionreceptors(PRRs),recognize molecules that are broadly shared by pathogens but distinguishablefrom host molecules,collectively referred to as pathogen-associated molecularpatterns(PAMPs).The detection of intracellular DNA has emerged as a key event in theinnate immune response to viruses and intracellular bacteria,and during conditions ofsterile inflammation and *** of the consequences of the detection of DNAas a‘stranger’and a‘danger’signal is the production of type I interferons and *** efforts are being made to understand the mechanismsof the recognition of innate immune system to intracellular *** major academicachievements of our group include the clarification of the following points:1)the structuralbasis for recognization of small molecules such as bis-(3',5')-cyclic dimeric guanosinemonophosphate(c-di-GMP)by STING and the molecular mechanisms of TBK1 activationafter pathogen infection(Ouyang et al,Immunity.2012);2)the structural and functionalbasis for activation of TLR9 signaling pathway and its negative regulation(Zhao et al,CellRes.2014;Niu et al,Protein Cell.2014);3)DDX41 can sense both DNA and cyclic dinucleotides(Parvatiyar et al,Nat Immunol.2014);4)NLRC3,a member of the NLR family ofproteins,is a negative regulator of innate immune signaling induced by STING(Zhang etal,Immunity.2014);5)the development of potential drugs for autoimmune diseasescaused by the improper recognition of DNA(Ouyang et al,JMM.2012).

关键词： STING(STimulator of INterferon Genes) molecular mechanisms innate immunity

来源：评论

学校读者我要写书评

暂无评论

Rapamycin promotes Glt1 expression and glutamate uptake inastrocyte

Rapamycin promotes Glt1 expression and glutamate uptake inas...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：王雪琴许琪中国医学科学院基础医学研究所医学分子生物学重点实验室

Objective: Accumulating evidence indicates that inhibition of the mammalian target ofrapamycin(mTOR) pathway activation in rodent models of epilepsy has antiepileptogeniceffects, but the underlying mechanism is still unknown. Our previous study found that themTOR pathway is activated in astrocytes in mesial temporal sclerosis. We hypothesizedthat blocking the mTOR pathway in astrocyte could promote glutamate uptake by increasingGlt1 protein ***: We treated cultured astrocytes with 5nM rapamycin for 48 hours, then analysedthe expression of glutamate transporters Glt1, Xct and GS by western blot. Meanwhile,after rapamycin treated, adding 22 micromoles glutamate to the medium of astrocytes todetect the rapid reduction of extracellular glutamate by Glutamic acid/Glutamate OxidaseAssay Kit. Moreover, construction shRNA lentivirus S6, TSC1 and 4EBP1 to knockdown S6,TSC1 and 4EBP1 expression in astrocytes before analysed the Glt1 change by western ***: Rapamycin treated to inhibit mTOR passway increases the expression of proteinGlt1 to 1.8 fold and accelerates the rate of extracellular glutamate uptake to 2.1 folds, S6 knockdown increase Glt1 expression and TSC1 knockdown decrease Glt1 expression, bothhave a positive correlation with the declination of extracellular glutamate. However, Glt1 level shows no significant difference with 4EBP1 ***: we identify that mTOR acts as a negative regulator in regulating the expressionof Glt1 and glutamate uptake via S6 passway.

关键词： Glt1 rapamycin glutamate uptake astrocyte

来源：评论

学校读者我要写书评

暂无评论

A New Multiplex Assay of 20 In Del loci for Forensic Application

A New Multiplex Assay of 20 In Del loci for Forensic Applica...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：王鹏翔李存保严江伟内蒙古医科大学基础医学院中国科学院北京基因组研究所

Objective The pupose of the study is to develop a new multiplex assay of 20 InDel loci forforensic application, which could offer an effective, rapid method to detect degraded *** 20 InDel Locis from Human Genome Browser and dbSNP database which hasgood frequency distribution has been choosed, and all selected InDel markers distributedin the human autosomes, X and Y chromosome. Multiplex PCR systems of 20 selected In-Del markers were developed. The PCR production was genotyping using the long thinnon-denaturing polyacrylamide gels with EB staining, and also genotyping with ABI3130 XL Genetic Analyzer. A series of validation experiments were performed for the InDelmultiplex system. Results 20 InDel multiplex was successfully constructed, and the multiplexis stable and dependable. By the validation detection, we can draw the conclusion: thesensitivity of the system was 0.3ng template DNA. Its species specificity and tissue identitywere good. After using the degraded DNA template, it was showed that the multiplex systemhad a high successful rate for analysis of the degraded DNA. Conclusion A new multiplexassay of 20 InDel loci for forensic application was successfully structured and provedto be reliable which could offer a new effective way to analyse the degraded DNA.

关键词： polymerase chain reaction multiplex PCR insertion/deletion polymorphismd egraded DNA fluorescence labeling

来源：评论

学校读者我要写书评

暂无评论

An Analysis of Protein Bioinformatics Datasets Related to LewyBodies of Parkinson's Disease

An Analysis of Protein Bioinformatics Datasets Related to Le...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Xing-An LI Lin-Sen HU Key Laboratory for Honeybee Genetics and (Queen) Breeding Jilin Provincial Institute of Apicultural Science Laboratory for Proteomics Department of Neurology First Affiliated Hospital Jilin University

Lewy bodies(LBs) in dopaminergic neurons in substantia nigra pars compacta(SNpc) arethe cardinal pathological hallmark of Parkinson' disease(PD), while LBs and/ or Lewy neuritesare also seen in non-dopaminergic neurons in other brain regions of patients with PD,such as noradrenergic neurons in locus coeruleus(LC), and cholinergic neurons in prefrontalcortex(PFC) and temporal cortex(TC). To explicit protein contents of LBs in PD,here is an article that demonstrates five aspects of protein constitution of LBs by analyzingprotein bioinformatics datasets related to LBs in PD: 1, LBs is filled with 2 types of alpha-synuclein(α-SYN) positive fibrilar aggregates and/or 6 types of α-SYN positive nonfibrilaraggregates(described frequently in literature as oligomers);2, modification formsof pathological α-SYN in LBs are often associated with 5 species of chemical modifiers;3,19 α-SYN-associated proteins rich in LBs are respectively colocalized with α-SYN;4, 117 previously reported proteins in LBs in immunochemistry study are at least classified into 10 different groups of functional proteins with close relationship;5, proteomics database asprotein candidate resource for LBs contain 84, 124 and 120 proteins identified respectivelyfrom raw tissue samples of LC, SNpc and PFC regions, and 108 proteins identified from acellular separation of analyte captured from TC region, and 29 proteins identified from asub-cellular fraction of analyte isolated from TC region. It is suggested that the aforementionedaspects comprehensively and fundamentally reflect protein composition of LBs inPD.

关键词： Parkinson' disease Lewy bodies proteins bioinformatics

来源：评论

学校读者我要写书评

暂无评论

Notch signaling pathway regulates the polarization of macrophages and impact on the progression of tumor

Notch signaling pathway regulates the polarization of macrop...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者：叶雨辰秦鸿雁韩骅窦科峰第四军医大学西京医院肝胆外科第四军医大学基础部遗传与发育教研室

Objective:In the past few years,researchers have discovered that macrophages plays anpivotal role in chronic inflammatory diseases,such as *** macrophages participatein tumor progression and what molecular mechanisms orchestrate the function of macrophages,however,is yet unclear. We created tumor models based on WT C57BL/6 mice(WTmice) and mice with RBPJ specifically knocked-out in macrophages(KO mice),to observedthe effect of notch signaling blockade in macrophages on tumor development,andmoreover,the functional alteration of macrophages,aiming at searching for innovative targetfor medication of ***:We created models of subcutaneously inoculated lung cancer on WT mice andKO mice and observed the difference of tumor *** in percentage of immunecells,polarization of macrophages and expression of relative cytokines in tumor were respectivelydetected by FACS analysis,Immunofluorescent staining,and Quantitative ***:It was discovered that the subcutaneous tumor of KO mice is smaller than that ofWT *** expected,FACS analysis showed that the percentage of TAM of KO mice ***'s more,it was revealed by Immunofluorescent staining and Q-PCR that TAMin KO mice was more inclined to polarize towards an M1-like ***:Progression of subcutaneously inoculated lung cancer could be suppressed byspecific blockade of notch signaling in *** TAM formation and a moreM1-like state could account for this ***,targeting notch signaling inmacrophages might be a promising medication of cancer.

关键词： Notch信号通路巨噬细胞肿瘤肺癌

来源：评论

学校读者我要写书评

暂无评论

Screening Novel Inhibitors of Ornithine Decarboxylase, the key Enzyme in Polyamine Biosynthesis

Screening Novel Inhibitors of Ornithine Decarboxylase, the k...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Jingqiong Zhan Qian Li Bo Li Yanlin Wang Sen Liu Institute of Molecular Biology/College of Medical Science China Three Gorges University

The nature polyamines(putrescine, spermidine, and spermine)are ubiquitous polycationicalkylamines that play essential roles in many biological processes. Studies showed thatthe rapid growth of tumor cells needs a higher concentration of the intracellular polyaminesthan normal cells. It is also widely accepted that the dysregulation of polyamine metabolismcould cause malignant transformation of cells. Hence, polyamine metabolic pathwayis considered to be a promising target for antitumor *** decarboxylase(ODC) is the first rate-limiting enzyme in regulating intracellularpolyamine biosynthesis, and involved in many important physiological functions, includingembryonic development, cell cycle, cell proliferation and differentiation. At the same time,ODC is also needed by tumor cells for their rapid growth and proliferation. Currently,ODChas been used as a potential molecular target for anti-tumor ***, an irreversible inhibitor of ODC, is used at present in clinic, and can inhibit thegrowth of tumor cells. However, DFMO is not effective enough to warrant continued phaseII trials. Therefore, it has important clinical significance to explore new ODC inhibitors. Inour study, based on the ODC crystal structure, we are trying to select new ODC inhibitorsfrom the small molecule chemical database by computer simulation and experimental *** our virtural screening, we got 90 potential inhibitors. Among these compounds,our experiment confirmed that the compound D24 significantly inhibits A549 cell growthin cell-based assays, and can inhibit ODC enzyme activity as well. Further studies on thepotential mechanism are in progress.

关键词： polyamine metabolism Ornithine decarboxylase ODC inhibitors

来源：评论

学校读者我要写书评

暂无评论

Comprehensive Profiling of Accessible Surface Glycans of Mammalian Sperms Using a Lectin Microarray

Comprehensive Profiling of Accessible Surface Glycans of Mam...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Li Cheng Ai-Jie Xin Hui-Juan Shi Sheng-Ce Tao Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine (Ministry of Education) Shanghai JiaoTong University Shanghai Jiai Genetics & IVF Institute Obstetrics and Gynecology Hospital of Fudan University Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases

It is well known that cell surface glycans or glycocalyx play important roles in sperm motility,maturation and fertilization. A comprehensive profile of the sperm surface glycans willgreatly facilitate both basic research（sperm glycobiology） and clinical studies, such as diagnosticsof infertility. As a group of natural glycan binders, lectin is an ideal tool for cellsurface glycan profiling. However, because of the lack of effective technology, only a fewlectins have been tested for lectin-sperm binding profiles. To address this challenge, wehave developed a procedure for high-throughput probing of mammalian sperm with 91 lectins on lectin microarrays. Normal sperm from human, boar, bull, goat and rabbit werecollected and analyzed on the lectin microarrays. Positive bindings of a set of 0 lectinswere observed for all the sperm of 5 species, which indicated a wide range of glycans areon the surface of mammalian sperm. Species specific lectin bindings were also *** analysis revealed that the distances of the five species according to the lectinbinding profiles are consistent with that of the genome sequence based phylogenetic treeexcept for rabbit. The procedure that we established in this study could be generally applicablefor sperm from other species or defect sperm from the same species. We believethe lectin binding profiles of the mammalian sperm that we established in this study arevaluable for both basic research.

关键词： sperm glycocalyx surface glycan lectin microarray

来源：评论

学校读者我要写书评

暂无评论

Progranulin A9D mutation functionally leads to the cytoplasmretardation of angiogenin

Progranulin A9D mutation functionally leads to the cytoplasm...

引用

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Siqi Li Yongdui Chen Jinghao Sheng Haojie Dong Guangdi Chen Zhengping Xu Research Center for Molecular Medicine Zhejiang University School of Medicine

Neurodegenerative diseases are progressive neurological disorders with selective neuronloss in particular regions of brain,including frontotemporal lobar degeneration(FTLD),Alzheimer’s disease(AD),amyotrophic lateral sclerosis(ALS),Parkinson’s disease(PD),and many *** defects have been recognized as a prominent factor in the etiologyand pathogenesis of neurodegenerative *** date,hundreds of genetic variantsthat located in dozens of genes have beenassociated with susceptibility to various *** them,more than 60 mutations in progranulin(PGRN)havebeen reported in FTLD,AD,ALS and *** of the mutations in PGRN gene exon 1 introducesa charged amino acid in the hydrophobic core of the signal peptide at residue 9(PGRN A9D),and results in cytoplasmic mis-sorting of this ***,the mechanismof actions of this mis-sorting remains *** address this issue,we first examinedthe subcellular distribution of PGRN with A9D mutation in human neuronal-like cells(SHSY5Y).The results have shown that PGRN A9D mutation failed to undergo maturation andaccumulated in the stress ***,this mutation also induces redistributionof cellular angiogenin(ANG),a stress response factor and neurodegenerative diseases relatedprotein,from nuclear to *** was also directly interacted with ANG instress ***,the cytoplasmic retardation of ANG by PGRN A9D mutationabolished ANG-enhanced rRNA transcription and cell *** together,these resultsindicate that PGRN with A9D mutation changed localization of ANG as well as cellgrowth and survival,suggesting that PGRN and ANG act in concert to regulate the progressof neurodegenerative diseases.

关键词： Progranulin Neurodegenerative diseases Angiogenin stress granule

来源：评论

学校读者我要写书评

暂无评论

没有更多数据了...

全选清除本页清除全部题录导出标记到“检索档案”

共59页 << < 32 33 34 35 36 37 38 39 40 41 > >>

检索报告对象比较合并检索0

隐藏清空

合并搜索

回到顶部

执行限定条件

内容：

评分：

请选择保存的检索档案：

请选择收藏分类：

订阅名称：

通借通还

温馨提示：

图书名称：

借书校区：

取书校区：

手机号码：

邮箱地址：

一卡通帐号：

电话和邮箱必须正确填写，我们会与您联系确认。

联系人：

所在院系：

联系邮箱：

联系电话：

内蒙古自治区呼和浩特市赛罕区大学西街235号邮编: 010021

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：