G protein-coupled receptors(GPCRs)are the largest group of the cell membrane receptorsplaying critical biological *** genome encodes approximately 400 nonolfactory *** far,the endogenous ligands of approximately120 GP...
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G protein-coupled receptors(GPCRs)are the largest group of the cell membrane receptorsplaying critical biological *** genome encodes approximately 400 nonolfactory *** far,the endogenous ligands of approximately120 GPCRs are remainedun known and these receptors are termed as orphan ***/peptide ligandsactivate about
Accumulation of unfolded and misfolded proteins in the endoplasmic reticulum(ER)results in ER stress and lipid overload-induced ER stress has been implicated in the development of insulin *** evidence further demonstr...
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Accumulation of unfolded and misfolded proteins in the endoplasmic reticulum(ER)results in ER stress and lipid overload-induced ER stress has been implicated in the development of insulin *** evidence further demonstrates a close interplay between disturbances in mitochondrial function and ER homeostasis in the development of metabolic *** present investigation sought to advance our understanding of the mechanistic links among dysregulation of lipoprotein metabolism,mitochondrial dysfunction and ER stress in the onset of hepatic steatosis and insulin ***
Maintaining lipid homeostasis becomes more and more important for modern wealth *** human body,proper lipid metabolism is important for both adipose and non-adipose *** the cells,lipid homeostasis is achieved through ...
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Maintaining lipid homeostasis becomes more and more important for modern wealth *** human body,proper lipid metabolism is important for both adipose and non-adipose *** the cells,lipid homeostasis is achieved through several lipid metabolic processes including lipid biosynthesis,lipid utilization,lipid storage,and lipid *** mainly use Drosophila models to study the regulation of lipid storage in fat body,the adipose tissue,and salivary gland,a non-adipose tissue.
The faithful chromosome separation during cell division requires proper mitotic spindle assembly,a complicated but precisely-regulated process that relies on its coupling with the centrosome cycle and the kinetochore ...
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The faithful chromosome separation during cell division requires proper mitotic spindle assembly,a complicated but precisely-regulated process that relies on its coupling with the centrosome cycle and the kinetochore *** to the crucial links among the centrosome cycle,kinetochore formation and mitotic spindle assembly,defects in the structural dynamics and functions of these organelles often lead to abnormal mitotic
The SNARE complex involved in neurotransmitter release is composed of synaptobrevin on the synaptic vesicles,and syntaxin-1 and SNAP-25 on the plasma *** assembly of the SNARE complex is highly dynamic and critically ...
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The SNARE complex involved in neurotransmitter release is composed of synaptobrevin on the synaptic vesicles,and syntaxin-1 and SNAP-25 on the plasma *** assembly of the SNARE complex is highly dynamic and critically regulated by Munc18-1,Munc13-1,but the molecular mechanism of this process is still *** previous results suggested that syntaxin-1-Munc18-1 complex,rather than syntaxin-1-SNAP25
Asparaginyl endopeptidase(AEP)is an endo/lysosomal cysteine endopeptidase with a preference for asparagine in the P1 site and plays an important role in the maturation of Toll-like receptor(TLR)3/7/*** is known to und...
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Asparaginyl endopeptidase(AEP)is an endo/lysosomal cysteine endopeptidase with a preference for asparagine in the P1 site and plays an important role in the maturation of Toll-like receptor(TLR)3/7/*** is known to undergo autoproteolytic maturation at acidic pH for catalytic ***,we describe the crystal structures of the AEP proenzyme and the mature forms of AEP determined at 2.00 and
Lipid droplets(LDs)are a cellular organelle that consists of a neutral lipid core,monolayer phospholipid membrane and *** studies present that LDs are involved in lipid synthesis,storage,transportation,modification an...
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Lipid droplets(LDs)are a cellular organelle that consists of a neutral lipid core,monolayer phospholipid membrane and *** studies present that LDs are involved in lipid synthesis,storage,transportation,modification and hydrolysis,as well as in protein storage and ***,LD research plays important roles in understanding of metabolic diseases and development of *** structure-like proteins differ from other membrane proteins in that 1)they are barely detected in other cellular structures with bilayer phospholipid membrane,2)they do not have any sequence similarity among their membrane targeting *** mammals and Drosophila perilipin family proteins(PLINs)are the
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