Melanoma is the most aggressive form of skin cancer with notorious resistance to apoptosis,which is a major barrier to the successful melanoma *** 2011,FDA approved two new therapeutics for melanoma,vemurafenib and **...
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Melanoma is the most aggressive form of skin cancer with notorious resistance to apoptosis,which is a major barrier to the successful melanoma *** 2011,FDA approved two new therapeutics for melanoma,vemurafenib and *** vemurafenib is the most effective drug currently available for melanoma treatment,it is only of benefit to the late-stage melanoma patients with the BRAFV600E ***
The MLL family histone methyltransferases play an essential role in the maintenance of the histone H3 Lysine 4(H3K4)methylation status for gene expression during differentiation and *** histone methyltransferase(HKMT)...
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The MLL family histone methyltransferases play an essential role in the maintenance of the histone H3 Lysine 4(H3K4)methylation status for gene expression during differentiation and *** histone methyltransferase(HKMT)activity of MLL-family proteins is regulated by three conserved core subunits,WDR5,RbBP5 and *** we show that the RbBP5-Ash2L heterodimer is the minimum unit to interact with and activate MLL ***5 functions exclusively in the MLL1 complex as a
5-methylcytosine is a major epigenetic modification that is sometimes called"the fifth nucleotide."However,our knowledge of how offspring inherit the DNA methylome from parents is *** generated singlebase re...
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5-methylcytosine is a major epigenetic modification that is sometimes called"the fifth nucleotide."However,our knowledge of how offspring inherit the DNA methylome from parents is *** generated singlebase resolution DNA methylomes of gametes and early embryo in zebrafish and *** find that the sperm DNA methylome in zebrafish is inherited by early embryogenesis,while oocyte DNA methylome is ***,inheritance of the sperm methylome facilitates the epigenetic regulation of embryogenesis in *** mouse,we show that the existence of 5hmC and 5fC in both maternal and paternal genomes and find that
Brown adipose tissue is specialized to burn lipids for heat generation as a natural defense against cold and *** studies established microRNAs as essential regulators of brown adipocyte differentiation,but it remains ...
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Brown adipose tissue is specialized to burn lipids for heat generation as a natural defense against cold and *** studies established microRNAs as essential regulators of brown adipocyte differentiation,but it remains unknown whether microRNAs are required for the feature maintenance of mature brown *** address this question,we ablated Dgcr8,a key regulator of the microRNA biogenesis pathway,in mature brown as well as white *** adipose tissue-specific Dgcr8 knockout mice displayed enlarged but pale interscapular brown fat with decreased expression of genes characteristic of brown fat,and the mice were intolerant to cold *** vitro primary brown adipocyte cultures
Small RNAs are important components in the eukaryotic gene regulatory *** have evolved a complex system of small RNAs,among which the predominant species are microRNAs(miRNAs)and herterochromatic siRNAs(hc-siRNAs).miR...
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Small RNAs are important components in the eukaryotic gene regulatory *** have evolved a complex system of small RNAs,among which the predominant species are microRNAs(miRNAs)and herterochromatic siRNAs(hc-siRNAs).miRNAs mediate post-transcriptional gene regulation through target mRNA cleavage or translational repression,whereas hc-siRNAs direct de novo DNA methylation at homologous loci through a pathway known as RNA-directed DNA methylation(RdDM).We have recently discovered a novel class of small RNAs that are induced by DNA double-strand breaks(DSBs)in Arabidopsis and humans.
Previously we have identified SNX6 as cargo adaptor for the dynein-dynactin motor complex in retromermediated retrograde vesicular transport from endosomes to the trans-Golgi network(TGN).We then investigated the regu...
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Previously we have identified SNX6 as cargo adaptor for the dynein-dynactin motor complex in retromermediated retrograde vesicular transport from endosomes to the trans-Golgi network(TGN).We then investigated the regulatory mechanism underlying release of retromer-associated cargoes by the motor at the *** report that PI(4)P,a Golgi-enriched phosphoinositide,negatively regulates the protein–protein interaction between the
Mitochondrial inner membrane fusion depends on the dynamin-related GTPase OPA1 and the function of OPA1is regulated by proteolytic *** mitochondrial proteases Yme1L and OMA1 cleave OPA1 at S2 and S1sites,***,we show t...
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Mitochondrial inner membrane fusion depends on the dynamin-related GTPase OPA1 and the function of OPA1is regulated by proteolytic *** mitochondrial proteases Yme1L and OMA1 cleave OPA1 at S2 and S1sites,***,we show that OMA1 is cleaved to a short form(S-OMA1)by itself upon mitochondrial
The growth of solid tumors depends on *** therapies targeting tumor angiogenesis have been ***,poor response in some tumors and emerging resistance necessitate further investigations of new drug *** signal pathway pla...
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The growth of solid tumors depends on *** therapies targeting tumor angiogenesis have been ***,poor response in some tumors and emerging resistance necessitate further investigations of new drug *** signal pathway plays a pivotal role in vascular development and
Although food availability is a potent synchronizer of peripheral circadian clock in mammals,the underlying mechanism remains ***,we found that hepatic BMAL1,a core transcription activator of molecular clock,is regula...
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Although food availability is a potent synchronizer of peripheral circadian clock in mammals,the underlying mechanism remains ***,we found that hepatic BMAL1,a core transcription activator of molecular clock,is regulated by an oscillator consisting of the temporal signals of fasting and refeeding *** fasting,glucagon stimulates CREB/CRTC2-mediated transcription of ***,insulin suppresses such induction and BMAL1 activity by promoting its AKT-mediated Ser42-phosphorylation,nuclear export and ubiquitin-dependent *** insulin resistance
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