Amino acids are key metabolites that contain sources of carbon, hydrogen, oxygen and nitrogen. We found that each aminoacyl tRNA-synthetase (ARS) senses its cognate amino acid sufficiency through catalyzing the format...
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Amino acids are key metabolites that contain sources of carbon, hydrogen, oxygen and nitrogen. We found that each aminoacyl tRNA-synthetase (ARS) senses its cognate amino acid sufficiency through catalyzing the formation of lysine aminoacylation (K-AA) on its specific substrate proteins. These non-canonical functions of ARSs sense amino acids and transmit their signals to signaling network of ***
Hepatic energy metabolism is tightly regulated by hormonal and nutritional signals. Dysfunction of both regulatory signals and energy metabolism is linked to metabolic diseases. Here we show that mTOR phosphorylates t...
详细信息
Hepatic energy metabolism is tightly regulated by hormonal and nutritional signals. Dysfunction of both regulatory signals and energy metabolism is linked to metabolic diseases. Here we show that mTOR phosphorylates tight junction protein and thereby orchestrates hepatic energy metabolism.
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