Membrane lipids are extremely diverse and have heterogeneous distributions in the lipid bilayer, which enable sophisticated spatiotemporal regulations of T cell signaling. We previously show that acidic phospholipids ...
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Membrane lipids are extremely diverse and have heterogeneous distributions in the lipid bilayer, which enable sophisticated spatiotemporal regulations of T cell signaling. We previously show that acidic phospholipids can ionically interact with juxtamembrane polybasic sequences to sequester T-cell receptor and CD28 phosphorylation sites within the membrane, thus providing gatekeeper regulation on the receptor
It is challenging to assess protein-membrane interactions because of the lack of appropriate tools to detect position changes of single proteins in～4 nm space of biological membranes. We recently developed two method...
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It is challenging to assess protein-membrane interactions because of the lack of appropriate tools to detect position changes of single proteins in～4 nm space of biological membranes. We recently developed two methods which we termed SIFA and LipoFRET, respectively, to track both vertical and lateral dynamic motionofsingly-labele*** and LipoFRET are capable of monitoring three-dimensional movements of the fluorophore-labeled
Bile acids have long been known to facilitate digestion and absorption of lipids in the small intestine as well as regulate cholesterol homeostasis. Desregulation of bile acid metabolism will lead to cholestatic cirrh...
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Bile acids have long been known to facilitate digestion and absorption of lipids in the small intestine as well as regulate cholesterol homeostasis. Desregulation of bile acid metabolism will lead to cholestatic cirrhosis ***,themolecularmechanismofregulatingbileacidmetabolism remains obscure. Previous studies showed that bile acid feeding significantly promotes liver *** found that loss of Hippo signals induces a significant increase in bile acids levels while depletion of
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