The tail-specific PDZ-protease Prc is involved in periplasmic protein quality control and cell regulation in Gram-negative *** associates with NlpI,an outer membrane substrate adaptor with tetratricopeptide repeats,fo...
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The tail-specific PDZ-protease Prc is involved in periplasmic protein quality control and cell regulation in Gram-negative *** associates with NlpI,an outer membrane substrate adaptor with tetratricopeptide repeats,for efficient degradation of peptidoglycan hydrolase involved in cell wall *** have recently determined the crystal structures of the Prc in unliganded resting and liganded activating states,alone or in complex with *** series of structures reveal not only how Prc
Obesity is characterized by accumulation of adipocytes loaded with lipid droplets (LDs). By genetic screening in yeast, we demonstrated that the deletion of a previously uncharacterized gene, FLD1, results in the form...
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Obesity is characterized by accumulation of adipocytes loaded with lipid droplets (LDs). By genetic screening in yeast, we demonstrated that the deletion of a previously uncharacterized gene, FLD1, results in the formation of "super-sized" LDs (>50 times the volume of normal ones). Interestingly, null mutations of the mammalian orthologue of FLD1, SEIPIN, are associated with human Berardinelli-Seip Congenital
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