Glucose is not only the main source for energy, but also a precursor for the synthesis of many *** entering glycolysis, glucose is converted in three steps to fructose-1,6-bisphosphate (FBP), which is then split into ...
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Glucose is not only the main source for energy, but also a precursor for the synthesis of many *** entering glycolysis, glucose is converted in three steps to fructose-1,6-bisphosphate (FBP), which is then split into triose phosphates by FBP aldolases. Glucose deprivation activates AMP-activated protein kinase (AMPK), a sensor known to play a pivotal role in adaptive responses to energy stress, but it had been unclear how glucose deprivation is sensed and signals to activate AMPK and inactivate mTORC1.
Synapses are semi-membraneless, protein-dense, sub-micron chemical reaction compartments responsible for signal processing in each and every neuron. Proper formation and dynamic responses to stimulations of synapses b...
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Synapses are semi-membraneless, protein-dense, sub-micron chemical reaction compartments responsible for signal processing in each and every neuron. Proper formation and dynamic responses to stimulations of synapses both during development and in adult are fundamental to functions of mammalian brains. There are not any identical ones among trillions of synapses in a human brain. Using a biochemical reconstitution approach, it was shown that, both in solution and on supported membrane bilayers, multivalent interaction
Single-molecule techniques have become an indispensable tool for studying the dynamics of bio-molecules and ***,we survey important recent development in this field of research and provide an outlook on future *** be ...
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Single-molecule techniques have become an indispensable tool for studying the dynamics of bio-molecules and ***,we survey important recent development in this field of research and provide an outlook on future *** be concrete,we describe how to use magnetic tweezers(MT)and FRET techniques to catch the transient intermediates in the homologous recombination(HR)process,proving a deeper insight into molecular mechanism of HR.
Mammalian development begins with a zygote resulted from the fertilization of a sperm and an *** zygotic genome undergoes profound epigenetic reprogramming to prepare for *** biological significance and mechanisms of ...
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Mammalian development begins with a zygote resulted from the fertilization of a sperm and an *** zygotic genome undergoes profound epigenetic reprogramming to prepare for *** biological significance and mechanisms of reprogramming are poorly *** and others found that5-methylcytosine(5mC),a prominent base modification present in genomic DNA,is selectively oxidized and demethylated in mouse zygotes by the Ten-Eleven-Translocation(Tet)family of dioxygenases.
Seipin, the gene that causes Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), is important for adipocyte differentiation and lipid homeostasis. Our previous studies in Drosophila revealed that Seipin promote...
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Seipin, the gene that causes Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), is important for adipocyte differentiation and lipid homeostasis. Our previous studies in Drosophila revealed that Seipin promotes ER calcium homeostasis through the Ca2+-ATPase SERCA, but little is known about the events downstream of perturbed ER calcium homeostasis that lead to decreased lipid storage in Drosophila dSeipin
The construction of metal-binding sites into designed protein scaffolds is an ultimate test of our understanding of structurefunction relationships and it will eventually allow us to construct new proteins for biochem...
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The construction of metal-binding sites into designed protein scaffolds is an ultimate test of our understanding of structurefunction relationships and it will eventually allow us to construct new proteins for biochemistry and biotechnology applications and biological *** negative effects of cadmium ion(Cd)exposure on human health have been recognized for many ***,new technologies that can sequester and remediate cadmium efficiently from dilute
O-GlcNAc(O-linked N-acetylglucosamine)modification is a non-canonical form of protein glycosylation,which occurs intracellular and is dynamically *** mammalian cells,more than a thousand cytoplasmic,nuclear,and mitoch...
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O-GlcNAc(O-linked N-acetylglucosamine)modification is a non-canonical form of protein glycosylation,which occurs intracellular and is dynamically *** mammalian cells,more than a thousand cytoplasmic,nuclear,and mitochontrial proteins are post-translationally modified with O-GlcNAc,which regulates many important biological *** and OGA are two enzymes responsible for dynamically cycling O-GlcNAc on and off the modified *** O-GlcNAc affects protein
Relapse is the leading cause of mortality in children with acute lymphoblastic leukemia (ALL).We identified relapse-specific mutations in PRPS1 and elucidated a novel drug resistance mechanism involving deregulated fe...
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Relapse is the leading cause of mortality in children with acute lymphoblastic leukemia (ALL).We identified relapse-specific mutations in PRPS1 and elucidated a novel drug resistance mechanism involving deregulated feedback modulation of purine biosynthesis and competitive inhibition of thiopurine activation in childhood *** also noticed that RAS mutation in founder cell proceeds PRPS1 mutation in clonal
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