Lysine acetylation is among the first post-translational modifications of histones to be discovered. Most acetylation occurs on lysine residues located at flexible N-terminal tails of histones, and they play important...
详细信息
Lysine acetylation is among the first post-translational modifications of histones to be discovered. Most acetylation occurs on lysine residues located at flexible N-terminal tails of histones, and they play important roles in chromatin-based regulation of gene expression. Rtt109 is a unique histone acetyltransferase acetylating histone H3 lysine 56 (H3K56) located in the globular domain of histone H3, and the
Autophagy is a protein degradation process by which intracellular materials are recycled for energy ***,the metabolic status and energy source of autophagy-defective tumor cells are poorly ***,our data show that amino...
详细信息
Autophagy is a protein degradation process by which intracellular materials are recycled for energy ***,the metabolic status and energy source of autophagy-defective tumor cells are poorly ***,our data show that amino acid uptake from the extracellular environment is increased in autophagy-deficient cells upon glutamine *** elevated amino acid uptake results from activating transcription factor 4(ATF4)-dependent upregulation of AAT(amino acid transporter)gene
Protein function originates from a cooperation of structural rigidity,dynamics at different timescales and ***,how these three pillars of protein function are integrated is still only poorly *** we show how these pill...
详细信息
Protein function originates from a cooperation of structural rigidity,dynamics at different timescales and ***,how these three pillars of protein function are integrated is still only poorly *** we show how these pillars are connected in phosphorylation enzymes,specifically the protein tyrosine phosphatase PTP1 B and the serine/threonine kinase p38.A broad array of molecular tools are necessary to unravel these functions,but NMR spectroscopy plays the key role in analyzing the dynamics that drive the enzymatic cycle as well as allostery that controls enzymatic activity.
Viral nucleic acids are major signatures of invading viruses,and their recognition by various cellular pattern recognition receptors(PRRs) represents the first step towards efficient innate immune response to clear th...
详细信息
Viral nucleic acids are major signatures of invading viruses,and their recognition by various cellular pattern recognition receptors(PRRs) represents the first step towards efficient innate immune response to clear the *** of viral nucleic acids and signaling by the PRRs not only involves recruitment of distinct signaling components,but are also intensively regulated by cellular organelle trafficking and posttranslational *** this talk,I will focus on our recent findings on recognition of viral nucleic acids by a novel co-sensor,and regulation of innate antiviral response by organelle trafficking and posttranslational modifications.
心脏是胚胎发育过程中第一个形成并发挥功能的器官,也是与人类健康关系最密切的器官之一。作者于上世纪九十年代初利用果蝇模型首次发现并证明Wnt信号控制胚胎心脏的发育,该发现被国际同行通过脊椎动物如非洲爪蟾、斑马鱼和小鼠模型予以印证。然而,美国国家科学院院士Eric N Olson教授在Science杂志发表评论指出,吴等证明Wnt信号在果蝇中激活心脏发育,而该信号在脊椎动物中却抑制心脏的发育。这种有关经典Wnt信号控制心脏发育的矛盾结果直到2007年才得以解决。但同年又出现经典Wnt信号是促进还是抑制衰老的新矛盾。作者进行了果蝇全基因组P转座子插入基因突变,获得了如Pygo,Nulp1和SMRH等一批经典Wnt信号的候选因子。Pygo随后被国际上4个实验室在Cell等杂志分别发表论文证明其是经典Wnt信号的新成员,但出乎意料的是,作者发现Pygo并不通过经典Wnt信号控制心脏瓣膜的形成与心脏衰老的发生。作者曾报道Nulp1是一种新型的b HLH转录因子,最近证明该基因是经典Wnt信号的新辅助激活子,能拯救经典Wnt信号抑制子GSK-3β导致的突变表型,与经典Wnt信号具有相同的调控该信号靶基因表达的作用模式。作者也惊奇地发现,SMRH1如同超级主控基因对经典Wnt信号的表达起负调控作用,其突变导致"无心"胚胎。本报告将介绍作者对这些经典Wnt信号新候选因子控制心脏发育与衰老的研究进展。
The increase in fructose consumption has been of particular concern to our *** exhibits distinct metabolic features and biological effects in vivo compared with *** and chronic consumption of dietary fructose is highl...
详细信息
The increase in fructose consumption has been of particular concern to our *** exhibits distinct metabolic features and biological effects in vivo compared with *** and chronic consumption of dietary fructose is highly linked to the pathogenesis of metabolic ***,the mechanism about the regulation of fructose metabolism remains *** identified that the transcription factor ChREBP(carbohydrate response element binding protein)controls fructose absorption in intestine through regulating the expression of fructose transporter Glut5 and some critical gluconeogenic
暂无评论