Drug discovery,from its traditional area of lead discovery and optimization,has extended toward two directions: upstream for target identification and validation,and downstream for preclinical *** directions are assoc...
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Drug discovery,from its traditional area of lead discovery and optimization,has extended toward two directions: upstream for target identification and validation,and downstream for preclinical *** directions are associated with discovering new pathogenic pathways or re-evaluating existing *** biology is a new discipline to fulfill such kind of *** will demonstrate how to identify potential drug targets and related pathwaysusing active natural compounds as *** the discovered acting pathway we optimized the natural products to obtained drug candidates.
Linker histone H1 has a key role in maintaining higher order chromatin structure and genome stability,however, studies on H1 are relatively rare. We recently focused on exploring H1's new function especially in ca...
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Linker histone H1 has a key role in maintaining higher order chromatin structure and genome stability,however, studies on H1 are relatively rare. We recently focused on exploring H1's new function especially in cancer cells underwent stress conditions. For example, we identified that acetylation of lysine 85(K85) within the H1 globular domain is a critical post-translational modification that regulates chromatin
The assembly of phase-separated structures is thought to play an important role in development and disease,but little is known about the regulation and function of phase separation under physiological conditions. We s...
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The assembly of phase-separated structures is thought to play an important role in development and disease,but little is known about the regulation and function of phase separation under physiological conditions. We showed that during C. elegans embryogenesis, PGL granules assemble via liquid-liquid phase separation(LLPS), and their size and biophysical properties determine their susceptibility to autophagic *** receptor SEPA-1 promotes LLPS of PGL-1/-3, while the scaffold protein EPG-2 controls the size
The microtubule cytoskeleton network orchestrates cellular dynamics and chromosome stability during *** recent studies identify a mechanism by which the TIP150-EB1 interaction governs kinetochore microtubule plus-end ...
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The microtubule cytoskeleton network orchestrates cellular dynamics and chromosome stability during *** recent studies identify a mechanism by which the TIP150-EB1 interaction governs kinetochore microtubule plus-end plasticity and establish that the temporal control of the TIP150-EB1 interaction by PCAF acetylation ensures chromosome stability in *** biochemical characterization revealed that PCAF acetylates EB1 on K220 and disrupts the stability of a hydrophobic cavity on the dimerized EB1 C
Growth signals, such as extracellular nutrients and growth factors, have substantial effects on genome integrity;however, the direct underlying link remains unclear. Here, we show that the mechanistic target of rapamy...
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Growth signals, such as extracellular nutrients and growth factors, have substantial effects on genome integrity;however, the direct underlying link remains unclear. Here, we show that the mechanistic target of rapamycin (mTOR)–ribosomal S6 kinase (S6K) pathway, a central regulator of growth signalling,phosphorylates RNF168 at Ser60 to inhibit its E3 ligase activity, accelerate its proteolysis function and impair its function in the DNA damage response, leading to accumulated unrepaired DNA and genome
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