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Regulation of LDL cholesterol by LIMA1/SREBP3

Regulation of LDL cholesterol by LIMA1/SREBP3

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Bao-Liang Song College of Life Sciences Wuhan University

High levels of low-density-lipoprotein cholesterol(LDL-C) is a major risk factor for cardiovascular *** LDL-C levels vary among humans and are heritable,the genetic factors affecting LDL-C are not fully ***,we identified a rare frameshift variant in the LIMA1(EPLIN or SREBP3) gene from a Chinese Kazakh ethnic family with inherited low LDL-C and reduced cholesterol ***1 was mainly expressed in the small intestine and localized on the brush border ***1 bridged NPC1 L1,an essential protein for cholesterol absorption,to a transportation complex containing myosin Vb and facilitated cholesterol ***1-deficient mice displayed reduced cholesterol absorption and were resistant to diet-induced hypercholesterolemia similar to the human ***,this study identifies LIMA1 as a key protein regulating intestinal cholesterol absorption.

关键词： cholesterol LIMA1 LDL NPC1L1

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Function of TXNIP on lipid accumulation in LO2 cell

Function of TXNIP on lipid accumulation in LO2 cell

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： GaoWenchao Lu Kang Li Ye Medical Faculty Kunming University of Science and Technology

Thioredoxin interacting protein(TXNIP) plays an important role in glucose-lipid *** acid synthase(FASN) catalyzes the last step in fatty acid biosynthesis,and thus,it is believed to be a major determinant of the maximal hepatic capacity to generate free fatty acid by de novo *** studies found that TXNIP protein level decreased(P<0.05) and FASN level increased(P<0.05) in the LO2 nonalcoholic fatty liver cell *** prompt TXNIP involved in lipid *** we knockdown TXNIP by siRNA(P<0.01) in LO2 *** then we detected the expression of TXNIP and FASN by western *** found knockdown TXNIP(P<0.05) caused the FASN protein increased(P<0.05),and induced the lipid accumulation by oil red staining in LO2 ***,TXNIP could play an important role via in hepatocellular lipid accumulation through *** TXNIP would cause lipid accumulation in hepatic cells.

关键词： Thioredoxin interacting protein lipid accumulation hepatic cells

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Changes in prothrombin time and platelet parameters of mice treated with vitamins C and E

Changes in prothrombin time and platelet parameters of mice ...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Hongwei Li Xiangcui Chen Yujun Zhang Qinglu Wang Key Laboratory of Biomedical Engineering & Technology Qilu Medical University

This study aimed to elucidate the effects of supplementation with different doses of vitamin C(VC) and vitamin E(VE) on prothrombin time(PT) in mice;Forty-eight mice were randomly divided into six treatment groups that were fed different dose VC and VE except for control check(CK) for eight *** eight weeks,blood samples were obtained from the mouse canthus for the analysis of PT and platelet *** PT and platelet parameters results show that VC group,different doses of VE and VC&VE group was effective in PT,Platelet count(PLT) and Platelet hematocrit(PCT).F-test There is no significant difference between the platelet distribution width(PDW) and mean platelet volume(MPV) of different groups revealed an F-value of 0.547(p>0.05).The combined use of VC and VE decreased coagulation function in mice.

关键词： Vitamin C Vitamin E Prothrombin time Platelet parameters

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Rational Design of a Broad-spectrum Vaccine by Compromising Viral-Type Specificity——a Type-Cross Human Papillomavirus Vaccine

Rational Design of a Broad-spectrum Vaccine by Compromising ...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者：李少伟 State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Life SciencesXiamen University National Institute of Diagnostics and Vaccine Development in Infectious Disease School of Public HealthXiamen University

Persistent,high-risk human papillomavirus(HPV)infection is the primary cause of cervical *** antibodies elicited by L1-only virus-like particles(VLPs)can block HPV infection;however,the lack of high-resolution structures has limited our understanding of the mode of virus infection and the requirement for type specificity at the molecular ***,we describe two antibodies,A12A3 and28F10,that specifically bind to and neutralize HPV58 and HPV59,respectively,through two distinct binding *** show that the epitopes of A12A3 are clustered in the DE loops of two

关键词： HPV Rational Design of a Broad-spectrum Vaccine by Compromising Viral-Type Specificity a Type-Cross Human Papillomavirus Vaccine

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Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue

Stimulation of histamine H4 receptor participates in cold-in...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Ya-Xin Zhao Jia-Bao Pan Shu-Wen Qian Qi-Qun Tang The Key Laboratory of Metabolism and Molecular Medicine Ministry of EducationInstitutes of Biomedical SciencesDepartment of Biochemistry and Molecular BiologyDepartment of Endocrinology and Metabolism of Zhongshan HospitalFudan University

While many studies have shown that histamine and its signaling regulate energy homeostasis through the central nervous system (CNS), their roles in adipose tissues remain poorly understood. We found the HrH4expression was significantly induced in subcutaneous adipose tissue in response to cold exposure by both quantitative PCR and Western blot. Functions of HrH4 in the browning process of white adipose tissue(WAT) and energy expenditure were explored after subcutaneous injection of HrH4 knockdown adenovirus

关键词： ERK Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue

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Bromodomain-containing protein 2 induces lipolysis in white adipose tissue via ERK/HSL signalling

Bromodomain-containing protein 2 induces lipolysis in white ...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Jiuyu Zong Shuting Li Yuxiong Wang Wei Mo Ruixin Sun Min Yu The Key Laboratory of Metabolism and Molecular Medicine the Ministry of EducationDepartment of Biochemistry and Molecular BiologySchool of Basic Medical ScienceFudan University State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of Medicine

White adipose tissue(WAT)dysfunction is prevalent among patients with type 2 diabetes mellitus(T2DM).Uncontrolled free fatty acid(FFA)release from WAT stores has detrimental effects on lipid metabolism,leading to insulin ***-containing protein 2(Brd2)has emerged as a central transcriptional regulator of adipocyte differentiation and pancreaticβ-cell ***,Brd2 overexpression leads to insulin resistance in ***,the mechanisms

关键词： HSL ERK Bromodomain-containing protein 2 induces lipolysis in white adipose tissue via ERK/HSL signalling FFA

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LSD1 ablation stimulates anti-tumor immunity and enables checkpoint blockade

LSD1 ablation stimulates anti-tumor immunity and enables che...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Sheng WQ LeFleur MW Sharpe AH Y.Shi Boston Children's Hospital and Department of Cell Biology Harvard Medical School Department of Microbiology and Immunobiology Harvard Medical School

Chromatin regulators play a broad role in regulating gene expression,and when gone awry,can lead to *** we demonstrate that ablation of the histone demethylase LSD1 in cancer cells leads to dsRNA stress and activation of type 1 interferon,which stimulates anti-tumor T cell immunity and restrains tumor ***,LSD1 depletion enhances tumor immunogenicity and T cell infiltration in poorly immunogenic tumors,and elicits significant responses of checkpoint blockade-refractory mouse melanoma to anti-PD-1 *** study identifies LSD1 as a potent inhibitor of anti-tumor immunity

关键词： LSD1 ablation stimulates anti-tumor immunity and enables checkpoint blockade

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Control of lipid homeostasis by CIDE proteins

Control of lipid homeostasis by CIDE proteins

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Peng Li School of Life Sciences Tsinghua University

Lipid homeostasis is crucial in maintaining normal physiological function and its dysregulation results in the development of obesity,diabetes,cardiovascular disease and *** droplets(LDs) are responsible for lipid storage and intracellular lipid *** have shown that CIDE family proteins,a class of LD-and ER-associated proteins,are important regulatory factors for LD growth and lipid storage by promoting atypical form of LD ***,we show that CIDEB is a novel component of COPII vesicles that selectively promotes the loading of SREBP/*** deprivation,while freeing SCAP from INSIG,induces the interaction between SCAP and CIDEB to enhance ER export of SREBP/SCAP,thereby modulating sterol ***,CIDEB binds to the guanine nucleotide exchange factor SEC12 to enrich SCAP/SREBP at ER exit sites,where assembling of COPII complex *** of CIDEB inhibits the cargo loading of SREBP/SCAP,reduces SREBP activation,and alleviates diet-induced hepatic steatosis and *** data point to a linchpin role of CIDEB in regulated ER export of SREBP and lipid homeostasis.

关键词： SREBP Control of lipid homeostasis by CIDE proteins

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Characterization of chondroitinase 1816 from Microbulbifer sp. ALW1

Characterization of chondroitinase 1816 from Microbulbifer s...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Liang Meifang Zhu Yanbing College of Food and Biological Engineering

The gene of chondroitinase 1816(ChSase1816) was overexpressed and purified from Escherichia coli BL21(DE3) with a molecular mass of 86 *** the chondroitin sulfate B(CS-B) as the substrate,the Km and Vmax values of ChSase1816 towards CS-B was 7.85 μg/mL and 1.21 U/*** optimum reaction temperature and pH for ChSase1816 were 30℃ and 8.0,*** ChSase1816 activity was stable at 30°C,but not stable at 50°C and 60°***,ChSase1816 retained more than 60% of its maximum activity at a broad pH range of pH 4.0 and *** the metal ions detected had inhibitory effects on the *** result of Circular dichroism(CD) indicated the enzyme contained many antiparallel structure and random *** antioxidant activity assay showed that hydroxyl radical scavenging activity of chondroitin enzymatic hydrolysates was higher than chondroitin sulfate.

关键词： Chondroitinase Enzymatic properties Enzymatic hydrolysate

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分子伴侣蛋白质二硫键异构酶对Tau蛋白错误折叠的调控

分子伴侣蛋白质二硫键异构酶对Tau蛋白错误折叠的调控

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者：王侃刘嘉琪刘晓灵高莹莹陈杰梁毅病毒学国家重点实验室武汉大学生命科学学院

蛋白质二硫键异构酶(PDI)具有折叠酶和分子伴侣等多种生物学功能。胞内的蛋白质发生错误折叠后会使内质网受到损害,此时细胞内的PDI的表达水平就会上调,发挥保护细胞的功能。我们发现PDI的a和a’结构域的CGHC的半胱氨酸在其与人Tau蛋白... 详细信息

蛋白质二硫键异构酶(PDI)具有折叠酶和分子伴侣等多种生物学功能。胞内的蛋白质发生错误折叠后会使内质网受到损害,此时细胞内的PDI的表达水平就会上调,发挥保护细胞的功能。我们发现PDI的a和a’结构域的CGHC的半胱氨酸在其与人Tau蛋白相互作用中起到关键作用:野生型PDI与Tau蛋白单体结合形成1:1复合物;PDI a结构域的C53/56A和a’结构域的C397/400A突变体与Tau蛋白单体结合形成2:1复合物;而a和a’结构域的四个半胱氨酸C53/56/397/400A突变体则丧失了与Tau蛋白单体相互作用的能力。野生型PDI与二硫键异构酶活性缺失突变体C4A都具有分子伴侣活性,能够抑制Tau蛋白在体外的积聚,且随PDI浓度升高抑制效果更加明显,具有浓度依赖性,在可诱导细胞模型中,我们使用confocal实验和双分子荧光互补实验(BiFC)证实神经细胞中过表达的野生型PDI、C4A突变体都与异常磷酸化修饰的Tau蛋白在内质网中存在相互作用,细胞实验表明C4A突变体和野生型PDI一样可以抑制细胞水平Tau蛋白的磷酸化修饰和积聚。这些结果说明PDI在抑制Tau蛋白磷酸化修饰和积聚过程中发挥的主要是分子伴侣的作用。此外,PDI可以显著降低由Tau蛋白寡聚体引发的细胞毒性。上述研究有益于阐释PDI抑制Tau蛋白的磷酸化修饰和积聚的分子机制及其在蛋白质质量控制中的作用,并为治疗阿尔茨海默病提供了一种新的策略。

关键词： Tau蛋白阿尔茨海默病蛋白质二硫键异构酶分子伴侣蛋白质错误折叠磷酸化修饰

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