检索结果-内蒙古大学图书馆

中国科技术语 2019年第1期21卷 75-75页

作者：高素婷不详

2018年10月25日至29日,“第二届生物化学与分子生物学名词编写委员会第二次全体委员扩大会议”与“中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议”在重庆召开。会议特邀中国生物化学与分子生物学会理事长... 详细信息

2018年10月25日至29日,“第二届生物化学与分子生物学名词编写委员会第二次全体委员扩大会议”与“中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议”在重庆召开。会议特邀中国生物化学与分子生物学会理事长李林院士出席会议并致辞,中国生物化学与分子生物学会专职副秘书长孙晓丽,山西大学生命科学院裴雁曦教授,重庆医科大学基础医学院雷云龙副教授,中山大学生命科学院屈良鹄教授,中国生物化学与分子生物学报编辑部贾竹青、陈苹,全国科技名词委高素婷编审、第二届生物化学与分子生物学名词编写委员会全体委员参会。会议由李刚教授主持。

关键词：中国生物化学与分子生物学会科技名词编写会员代表大会学报编辑部学术会议山西大学医科大学

来源：评论

学校读者我要写书评

暂无评论

一种软骨修复用水凝胶的制备及其用于软骨损伤修复的研究

一种软骨修复用水凝胶的制备及其用于软骨损伤修复的研究

引用

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者：李静静傅松涛山西医科大学山西省生物医药健康研究生教育创新中心

背景:由于无血管结构和无神经组织,关节软骨缺乏自我再生的内在能力,关节软骨损伤的修复仍然是一个重大挑战。目前,许多治疗方法用来解决软骨修复问题,如自体移植和同种异体移植,但仍存在供体不足,手术操作复杂,手术费用昂贵等显着缺点... 详细信息

背景:由于无血管结构和无神经组织,关节软骨缺乏自我再生的内在能力,关节软骨损伤的修复仍然是一个重大挑战。目前,许多治疗方法用来解决软骨修复问题,如自体移植和同种异体移植,但仍存在供体不足,手术操作复杂,手术费用昂贵等显着缺点。幸运的是,软骨组织工程提供了一种有前途的替代策略。方法:本研究中,我们制备了一种琼脂糖/明胶/透明质酸/DBM热敏性可注射生物活性水凝胶,并通过扫描电镜观察其三维结构,体外检测其溶胀率、生物力学强度和体外降解率等指标对其进行表征。通过活/死细胞荧光双染法评价该水凝胶的细胞相容性,然后将该水凝胶与软骨细胞-骨髓间充质干细胞(CHs-BMSCs)共培养系统复合培养,用于关节软骨损伤修复。并采用组织学方法和免疫组化染色法检测了CHs-BMSCs共培养系统在琼脂糖/明胶/透明质酸/DBM水凝胶支架中的体内软骨形成情况。结果:体外实验结果表明,该水凝胶具有良好的三维网络结构,孔径大小及孔隙率适合细胞粘附、增殖;其溶胀率适中,表明其具有良好的保水能力;其力学强度与人正常软骨生物力学强度接近;体外降解率与人的软骨基质形成速率相差不多;且细胞在该水凝胶中的存活率均在90%以上,表明其细胞毒性比较低。体内实验结果证实,与其他组相比,琼脂糖/明胶/透明质酸/DBM水凝胶支架复合细胞共培养系统组在大鼠软骨缺陷部位产生更成熟的组织,组织更整合并含有更高水平的COL II和Aggrecan,表明其更有利于软骨组织的产生。结论:我们制备的DBM颗粒官能化的琼脂糖/明胶/透明质酸水凝胶是用于软骨组织工程的良好候选医用生物材料。琼脂糖/明胶/透明质酸/DBM水凝胶支架复合细胞共培养系统为软骨缺损修复提供了一种有希望的途径。

关键词：水凝胶软骨细胞间充质干细胞脱钙骨基质颗粒软骨修复

来源：评论

学校读者我要写书评

暂无评论

Quantitative Analysis of Interactive Behavior of Mitochondria and Lysosomes Using Structured Illumination Microscopy

Quantitative Analysis of Interactive Behavior of Mitochondri...

引用

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Qixin Chen Xintian Shao Mingang Hao Zhiqi Tian Chenran Wang Fei Liu Fengshan Wang Peixue Ling Jun-Lin Guan Jiajie Diao School of Pharmaceutical Sciences Shandong University Department of Cancer Biology University of Cincinnati College of Medicine Shandong Academy of Pharmaceutical Science Key Laboratory of BiopharmaceuticalsEngineering Laboratory of Polysaccharide DrugsNational–Local Joint Engineering Laboratory of Polysaccharide Drugs

Super-resolution optical microscopy has extended the scope of cell biology from the cellular level to the nanoscale,giving researchers the ability to observe the interactive behavior of single mitochondria and ***,we are still without an applicable quantitative analysis system to assist us in understanding interactive behavior of mitochondria and lysosomes under super-resolution optical ***,we introduce an M-value to quantitatively investigate mitochondria and lysosome contact(MLC) and mitophagy under structured illumination *** found that the M-value for an MLC is typically less than 0.4,whereas in mitophagy it ranges from 0.5 to *** system permits further investigation of the detailed molecular mechanism governing the interactive behavior of mitochondria and lysosomes.

关键词： mitochondria lysosome mitophagy membrane fusion,super-resolution imaging

来源：评论

学校读者我要写书评

暂无评论

Medical Nanorobots for Tumor Microenvironment Targeting and Regulation

Medical Nanorobots for Tumor Microenvironment Targeting and ...

引用

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Guangjun Nie National Center for Nanoscience and Technology

It has witnessed that the rapid development on precision design and fabrication of intelligent next generation nanomedicine-medical nanorobots hold the great potential to revolutionize the current landscape of drug *** is also clear that tumor microenvironment plays critical roles on either promotion or restriction on primary tumor rapid growth and *** achievements have made targeting and regulation of tumor microenvironment via nanobiomaterials a feasible and fruitful strategy,to improve the therapeutic outcomes for cancer *** presentation will feature our recent development on using DNA and protein based nanorobots as intelligent nanomedicines to regulate tumor microenvironment to block tumor microvessels or re-store the homeostasis of tumor *** molecular systems have great potential as intelligent vehicles to enable the delivery of various potent molecules,which otherwise never could be used as therapeutics due to numerous ***,achieving in vivo,precise molecular-level,and on-demand targeting and delivery has proven extremely *** developed an autonomous nanorobotic system for targeted cancer therapy,programmed to transport molecular payloads and cause on-site tumor *** the robust self-assembly behavior,exceptional designability,potent antitumor activity and minimal in vivo adversity,the nanorobot represents a promising strategy for precise drug design for cancer therapeutics.

关键词： Nanorobots Tumor therapy Tumor vessels Tumor microenvironment Nanomedicine

来源：评论

学校读者我要写书评

暂无评论

Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria

Pyruvate cycle increases aminoglycoside efficacy and provide...

引用

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Yu-bin Su Xuan-xian Peng State Key Laboratory of Biocontrol School of Life SciencesSun Yat-sen University

The emergence and ongoing spread of multidrug-resistant bacteria puts humans and other species at risk for potentially lethal ***,novel antibiotics or alternative approaches are needed to target drug-resistant bacteria,and metabolic modulation has been documented to improve antibiotic efficacy,but the relevant metabolic mechanisms require more ***,we show that glutamate potentiates aminoglycoside antibiotics,resulting in improved elimination of antibiotic-resistant *** exploring the metabolic flux of glutamate,it was found that the enzymes that link the phosphoenolpyruvate(PEP)-pyruvate-AcCoA pathway to the TCA cycle were key players in this increased ***,the PEP-pyruvate-AcCoA pathway and TCA cycle can be considered the pyruvate cycle(P cycle).Our results show that inhibition or gene depletion of the enzymes in the P cycle shut down the TCA cycle even in the presence of excess carbon sources,and that the P cycle operates routinely as a general mechanism for energy production and regulation in Escherichia coli and Edwardsiella *** findings address metabolic mechanisms of metabolite-induced potentiation and fundamental questions about bacterial biochemistry and energy metabolism.

关键词： P cycle TCA cycle energy metabolism metabolites antibiotic resistance

来源：评论

学校读者我要写书评

暂无评论

PAQR9 promotes HFD-induced fatty liver by impairing thermogenesis

PAQR9 promotes HFD-induced fatty liver by impairing thermoge...

引用

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Xue You Yan Chen CAS Key Laboratory of Nutrition and Metabolism Institute for Nutritional SciencesShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of Sciences

PAQR9 is a member of the PAQR(progestin and adipoQ receptor) family,however,the investigation of obesity by PAQR9 has not been ***9 knockout(KO) mice are resistant to high fat diet(HFD)-induced obesity,due to PAQR9-KO mice have lower body weight and fat mass than wild type(WT) when they are fed a *** course,oxygen consumption was significantly higher in PAQR9-KO ***,PAQR9-KO mice reduces HFD-induced fatty *** mice shows more severe liver steatosis,higher levels of triglycerides(TG) and Total cholesterol(TC) than PAQR9-KO ***,PAQR9-KO mice have increased browning in BAT,because PAQR9-KO mice have decreased brown adipose tissue(BAT) lipid-droplet levels and higher expression levels of thermogenic ***,PAQR9-KO mice decreases obesity and metabolic syndrome through increasing browning in BAT.

关键词： PAQR9 Obesity

来源：评论

学校读者我要写书评

暂无评论

Endophytic fungi JXP25 extracts from Dalbergia odorifera T. Chen inhibits the growth of Staphylococcus aureus by damaging the cell membrane

Endophytic fungi JXP25 extracts from Dalbergia odorifera T. ...

引用

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Yuan Gao Xiaomeng Zhang Xue liu Junhan Guo Lijun Yan School of Pharmacy Harbin University Of Commerce Institute of Cell and Molecular Biology Harbin University of Commerce

This study investigated the antibacterial effects of the endophytic fungi from Dalbergia odorifera *** and the mechanism on Staphylococcus ***25 were isolated from bark of Dalbergia odorifera *** and identified by amplification of ITS rRNA gene *** antibacterial activity was determined by measuring the minimum inhibitory concentration(MIC),minimum bactericidal concentration(MBC),and the time-kill *** showed that endophytic fungi products can inhibit the growth of 5 pathogenic bacteria and the most susceptive strain was *** with the lowest MIC and MBC values of 0.13 and 0.50 mg/mL,*** membrane permeability study was determined by DNA leakage assay and electric conductivity *** the whole-cell protein lysates and DNA fragmentation assay were *** results indicated the DNA and protein of *** was decreased gradually with the increase of endophytic fungi products' *** probable antibacterial mechanism of endophytic gungi products was the change in permeability and integrity of the disrupted cell membranes,resulting in leakage of nucleic acids and *** study provides new insights for understanding the antibacterial actions of endophytic fungi products for biomedical applications.

关键词： Dalbergia odorifera T.Chen endophytic fungi antibacterial activity cell membrane

来源：评论

学校读者我要写书评

暂无评论

Mitochondrial ATP-Dependent Lon Protease and Cancer

Mitochondrial ATP-Dependent Lon Protease and Cancer

引用

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： LinhuaLan Kate Huang Ningning Zhou Yongzhang Liu Bin Lu Protein Quality Control and Diseases Laboratory School of Life SciencesWenzhou Medical University Department of Pathology The First Affiliated Hospital of Wenzhou Medical University

ATP-dependent Lon protease is a nuclear DNA-encoded mitochondrial enzyme highly conserved throughout evolution,contributed to the degradation of abnormal proteins within mitochondrial matrix,in the correct folding of proteins imported in mitochondria,as well as in the maintenance of mitochondrial *** expression of Lon is induced by various stimuli,including hypoxia and reactive oxygen species,which provides protection against cell *** up-regulation contributes to metabolic reprogramming in cancer cells,favors the switch from a respiratory to a glycolytic metabolism,helping cancer cell survival in the tumor microenvironment,and contributes to epithelial to mesenchymal transition(EMT).Knock-down of Lon expression,or pharmacological inhibition of its protease activity,leads to cell death in various cancer ***,Lon could be an independent prognostic factor for overall survival of bladder cancer and colon cancer *** together,Lon protease may be included in the growing class of proteins that are not responsible for oncogenic transformation,but that are important for survival and proliferation of cancer cells,and that could serve as a potential diagnostic biomarker and therapeutic target for treatment of various cancer,as well as for prediction of the effectiveness of chemotherapy.

关键词： Mitochondria Protease Lon Cancer

来源：评论

学校读者我要写书评

暂无评论

NMR Characterizations of a molecular chaperon: from order to disorder

NMR Characterizations of a molecular chaperon: from order to...

引用

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Xin-Chi Yu Yunfei Hu Jienv Ding Changwen Jin Beijing Nuclear Magnetic Resonance Center Peking University

In order to survive through the high acidity of their hosts' gastro environment before infecting the intestinal mucosa,all enteric bacteria are in need of an acid resistance system that could protect the bacterial proteins from being *** bacterial acid-resistant chaperone HdeA is a "conditionally disordered" protein that is activated via an order-to-disorder *** forms a well-folded dimer under neutral condition,and undergoes dimer dissociation and unfolding processes at low pH,which results in exposure of hydrophobic ***,the mechanism for unfolding-induced activation remains unclear due to the lack of experimental information on the unfolded state conformation and the chaperone-client *** using a number of state-of-the-art solution NMR methods,we characterized the activated state conformation of HdeA under acidic condition and investigated the interaction between HdeA and its native client *** data suggests that the activated HdeA becomes largely disordered and exposes two essential hydrophobic patches of residues for client *** pH-dependent chemical exchange saturation transfer(CEST) result identifies three acid-sensitive regions that act as structural locks during the activation process,revealing a multi-step activation mechanism of HdeA chaperone function at atomic level.

关键词： chaperon NMR order disorder interaction

来源：评论

学校读者我要写书评

暂无评论

Ribosylation induces cognitive impairment and neural cell death

Ribosylation induces cognitive impairment and neural cell de...

引用

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Yan WEI Rongqiao HE State Key laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of Sciences

D-ribose in cells and human serum participates in the glycation of proteins resulting in advanced glycation end products(AGEs) that affect cell metabolism and induce cell *** have been shown to be implicated in the senile plaques and neurofibrillary tangles in the brain of Alzheimer's *** high levels of ribose,along with glucose were found in the urine of patients with type 2 diabetic ***,the effects of D-ribose and ribosylation on protein,cell and animal were investigated by biochemical,cellular and animal *** with D-ribose induced protein to misfold rapidly and form globular amyloid-like aggregations which play an important role in cytotoxicity to neural cells.D-ribose also decreased cell viability and induced more AGE accumulation in *** injection,oral administration and tail intravenous injection of D-ribose caused impairment of spatial learning and memory ability in animals,along with A deposition,tau hyperphosphorylation and glia activation,which were the key pathological features in Alzheimer's *** may be some mechanistic link between ribosylation and cognitive *** ribosylation could be a promising therapeutic strategy to prevent Alzheimer's disease and diabetic encephalopathies.

关键词： ribosylation Alzheimer's disease tau hyperphosphorylation cognitive impairment

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：