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检索条件"任意字段=中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议"

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Transformation of coccolithophorid Emiliania huxleyi harboring a marine virus(Coccolithoviruses) serine palmitoyltransferase(SPT) gene by electroporation

Transformation of coccolithophorid Emiliania huxleyi harbori...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Cai Weicong Wang Xueting Guo Qiangqiang Li Guiling Zeng Jun Liu Jingwen College of Food and Bioengineering JiMei University

Emiliania huxleyi is the most prominent modern coccolithophore,a group of photosynthetic marine unicellular eukaryotes that play a critical role in ocean *** are large double stranded DNA viruses,which is responsible for the demise of large oceanic blooms formed *** virus acquired a series of enzyme-coding genes predicted to be involved in the sphingolipid biosynthesis by gene transfers between ***,there is limited experimental validation indentifying the functions of these *** palmitoyltransferase(spt) catalyzes the first committed step in de novo sphingolipid biosynthetic *** transformation of eukaryotic cells is a powerful tool to get an insight into gene functions of the studied ***,a novel vector system for the transformation of *** was *** contained larger fragments of promoter and terminator sequences of *** endogenic fucoxanthin chlorophyll a/c-binding protein gene "fcp" and harbored *** virus(EhV99 B1) spt *** resultant recombinant transformation vectors pEhux-I-spt and pEhux-II were co-transferred into *** BOF92 by *** were obtained upon glufosinate-ammonium selection,and confirmed by genome PCR,qRT-PCR and Western blot screening of spt gene,which indicated that spt gene was integrated into the nuclear genome and was expressed at the mRNA and protein *** expression of the viral spt gene led to the accumulation of lipid droplets in the transformed cells stained with Nile Red.

关键词： Emiliania huxleyi Coccllithovirus genetic transformation serine palmitoyltransferase

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Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production

Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Bin...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Zhizhang Wang Weijie Yin Lizhen Zhu Jia Li Yikun Yao Feifei Chen Mengmeng Sun Jiayuan Zhang Nan Shen Yan Song Xing Chang Shanghai Institute of Nutrition and Health Chinese Academy of Sciences Department of Cellular and Molecular Medicine University of California at San Diego

Iron deposition is frequently observed in human autoinflammatory diseases,but its functional significance is largely *** we showed that iron promoted proinflammatory cytokine expression in T cells,including GM-CSF and IL-2,via regulating the stability of an RNA-binding protein *** depletion or Pcbp1 deficiency in T cells inhibited GMCSF production by attenuating Csf2 30 untranslated region(UTR) activity and messenger RNA ***1 deficiency or iron uptake blockade in autoreactive T cells abolished their capacity to induce experimental autoimmune encephalomyelitis,an animal model for multiple ***,intracellular iron protected PCBP1 protein from caspase-mediated proteolysis,and PCBP1 promoted messenger RNA stability of Csf2 and Il2 by recognizing UC-rich elements in the 30 *** study suggests that iron accumulation can precipitate autoimmune diseases by promoting proinflammatory cytokine ***-binding protein-mediated iron sensing may represent a simple yet effective means to adjust the inflammatory response to tissue homeostatic alterations.

关键词： Autoimmune disease Iron GM-CSF PCBP1 Post-transcriptional regulation

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亚麻胰蛋白酶抑制剂降糖作用的分子机理研究

亚麻胰蛋白酶抑制剂降糖作用的分子机理研究

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者：王蕾吴莎莎吴峰石亚伟山西大学生物技术研究所教育部化学生物学与分子工程重点实验室

植物蛋白类的胰蛋白酶抑制剂(TI)具有抗癌、抗炎、抗病、抗虫、以及治疗心血管疾病、人类获得性免疫缺陷症等恶性疾病的潜在应用价值,然而对于其降糖活性的研究,虽有零星的动物实验,但因缺乏对应分子靶标以及相关构效关系研究,国内外对T... 详细信息

植物蛋白类的胰蛋白酶抑制剂(TI)具有抗癌、抗炎、抗病、抗虫、以及治疗心血管疾病、人类获得性免疫缺陷症等恶性疾病的潜在应用价值,然而对于其降糖活性的研究,虽有零星的动物实验,但因缺乏对应分子靶标以及相关构效关系研究,国内外对TI的降糖作用机理以及抑制α-葡萄糖苷酶活性的分子机制研究目前还处于空白阶段。近期,本课题组以抑制α-葡萄糖苷酶活性为评价指标,从对胡麻籽粕中分离到一个分子量为8kD的小分子多肽——亚麻胰蛋白酶抑制剂LUTI,该多肽具有抑制α-葡萄糖苷酶活性。随后,我们对该多肽进行了体外重组表达与纯化,获得了相同分子量的重组LUTI(rLUTI)。经抑制活性测定分析,相比天然LUTI,rLUTI对胰蛋白酶和α-葡萄糖苷酶的抑制作用明显升高。进一步我们利用基因定点突变技术分别获得rLUTI的C4/A,C49/A、D45/A、K46/A单突变体以及C4、49/A双突变体。圆二色谱分析显示, rLUTI第4位半胱氨酸是维持其二级结构稳定的关键位点。双酶抑制活性测定发现rLUTI的C4/A、C49/A及C4、49/A突变对胰蛋白酶抑制活性影响尤为明显,而对α-葡萄糖苷酶的抑制活性影响较小,其中rLUTI的C49/A及C4、49/A突变完全丧失了对胰蛋白酶的抑制活性;D45/A和K46/A突变体对α-葡萄糖苷酶抑制活性影响尤为明显,而对胰蛋白酶抑制活性影响较小。这一结果说明LUTI对胰蛋白酶和对α-葡萄糖苷酶活性的抑制机理存在明显不同。为了进一步分析LUTI抑制α-葡萄糖苷酶活性的构效关系,我们运用分子对接技术对LUTI与α-葡萄糖苷酶的结合位点进行了分析。结果显示,LUTI主要通过其N端与α-葡萄糖苷酶结合, Ser1、Arg2、Arg3和Pro5这4个氨基酸可能是二者结合的关键位点。

关键词：重组LUTI 胰蛋白酶 α-葡萄糖苷酶定点突变分子对接

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肿瘤抑制因子p53/p21信号通路的新调控因子XBP1-u

肿瘤抑制因子p53/p21信号通路的新调控因子XBP1-u

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者：黄灿吴寿荣江启慧重庆大学生物工程学院生物流变科学与技术教育部重点实验室国家“111计划”生物力学与组织修复工程学科创新引智基地

细胞周期是一个受到严密调控、有序的细胞重要活动过程。细胞周期调控异常会导致细胞增殖失控等细胞正常功能异常发生,与肿瘤等疾病密切相关。研究表明肿瘤抑制基因p53能显著促进细胞周期总调控因子p21转录活性,p53/p21信号通路是控制... 详细信息

细胞周期是一个受到严密调控、有序的细胞重要活动过程。细胞周期调控异常会导致细胞增殖失控等细胞正常功能异常发生,与肿瘤等疾病密切相关。研究表明肿瘤抑制基因p53能显著促进细胞周期总调控因子p21转录活性,p53/p21信号通路是控制细胞周期进程的核心调控途径。然而,目前有关该信号通路的分子调控机制仍尚未完全阐明清楚。为了系统阐明p53/p21信号通路的调控机制,我们构建了shRNA表达载体文库筛选体系,并对影响p21转录活性的因子展开了高通量筛选。通过该筛选系统,我们发现非剪接X-盒结合蛋白1(XBP1-u)是p53/p21信号通路的新型重要调控因子,并揭示了其对p53/p21信号通络的分子调控机制。研究结果表明XBP1-u能显著增强p53泛素化,抑制p53/p21信号通路。研究结果表明XBP1-u的缺失可显著诱导细胞周期G0/G1期阻滞并抑制肿瘤细胞增殖,XBP1-u缺失的细胞形成肿瘤的能力也显著降低。我们利用分子生物学和生物化学方法进一步阐明了XBP1-u对p53的调控机制,研究发现XBP1-u能结合鼠双微基因2(MDM2)。MDM2蛋白质是促进p53泛素化和蛋白酶降解从而抑制p53蛋白质积累的p53关键负调控因子。我们的研究结果显示,XBP1-u可抑制MDM2的自我泛素化,稳定MDM2蛋白质,从而促进p53泛素化和蛋白酶降解。另外,研究结果表明,XBP1-u上述调控功能的关键区域是其蛋白质的碳末端,而其碳末端与其剪切体XBP1-s的完全不同的。这些研究结果也解释了XBP1-u,而非其剪切体XBP1-s,对p53发挥重要调控功能。总之,本项目研究结果表明,非剪接型XBP1-u不仅仅是XBP1-s简单的前驱体,而是可以参与到细胞周期基础功能调控的重要因子。同时,本项目研究也为MDM2/p53/p21信号通路相关的调控机制提供了的新见解。

关键词： XBP1-u p21 p53 MDM2 细胞周期

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Cancer associated alteration of Human Serum IgG galactosylation and its potential as a pan-cancer diagnosis biomarker

Cancer associated alteration of Human Serum IgG galactosylat...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Shifang Ren Zejian Zhang Wenjun Qin Ruihuan Qin Jin Han Jianxin Gu Key Laboratory of Glycoconjugate Research Ministry of Public Health Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesFudan University

Analysis of blood-based glycans represents a new strategy for cancer *** G(IgG),a highly abundant glycoprotein in serum,is known to mediate a variety of blood immune *** has been an increasing interest in the analysis of the N-glycan profile of human IgG in healthy and disease states,such as auto-immune diseases and *** altered glycosylation of total serum IgG has been profiled individually in ovarian,prostate,gastric cancers,no studies have systematically investigated the alteration of IgG glycosylation in multiple cancers *** addition,the sample sizes in previous studies were *** high throughput analytical method based on mass spectrometry for relative quantitative analysis of IgG glycans we previously developed,we designed for the first time a large-scale(n=5600),multi-institute study to assess the quantitative changes of IgG glycosylation in 12 types of cancers,inflammatory diseases,benign conditions as well as healthy individuals *** demonstrated that the distribution patterns of serum IgG galactosylation have similar alterations in multiple types of *** thus we provided evidences for the first time that serum IgG galactosylation has great potential to be used as a non-invasive pan-cancer biomarker for early-stage cancer detection and cancer *** studies are underway to investigate the role and mechanism of IgG galactosylation in readout of immunological status.

关键词： IgG galactosylation cancer diagnosis pan-cancer biomarker

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10-Hydroxycamptothecin Mediates Antiproliferative Effects and Induces Autophagy in H1299 Cells

10-Hydroxycamptothecin Mediates Antiproliferative Effects an...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Li Jian Hong Tao Zhou Yang Yan Li-jun School of Pharmacy Harbin University of Commerce Institute of Cell and Molecular Biology Harbin University of Commerce Research Center on Life Sciences and Environmental Sciences Harbin University of Commerce

10-Hydroxycamptothecin(HCPT),a natural camptothecin(CPT) analog that is more potent anti-cancer activity,was widely used in recent clinical *** is becoming recognized as an important biological mechanism in human ***,the involvement of autophagy in the antiproliferative effects of HCPT on lung cancer remains *** we found that HCPT was able to reduce the cell viability on non-small cell lung cancer(NSCLC) H1299 cells after 24-h treatment as determined by MTT *** cytometry was used to distinguish between cells in different phases of the cell *** results showed that HCPT induced S phase and G2/M phase arrest,suggested that HCPT induced H1299 cell death by altering the cell cycle ***,HCPT remarkably induced the formation of autophagosomes with fluorescence microscopy after monodansylcadaverine(MDC) ***,HCPT obviously enhanced the expression of microtubule-associated protein 1 A/1 B-light chain 3-II(LC3-II) and down-regulated the expression of P62 in timedependent manners in H1299 ***,autophagy inhibitor 3-methyladenine(3-MA) and chloroquine(CQ) could inhibit HCPT mediated *** results demonstrated that HCPT was able to suppress proliferation and induce autophagy in H1299 cells,providing new mechanistic insights into the anticancer functions of HCPT.

关键词： HCPT autophagy H1299 non-small cell lung carcinoma

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CXXC5 suppresses hepatocellular carcinoma by promoting TGF-β-induced cell cycle arrest and apoptosis

CXXC5 suppresses hepatocellular carcinoma by promoting TGF-...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Xiaohua Yan Department of Biochemistry and Molecular Biology School of Basic Medical SciencesNanchang University

Evading TGF-β-mediated growth inhibition is often associated with tumorigenesis in liver,including hepatocellular carcinoma(HCC).To better understand the functions and the underlying molecular mechanisms of TGF-β in HCC initiation and progression,we carried out transcriptome sequencing(RNA-Seq) to identify the target genes of TGF-β.CXXC5,a member of the CXXC-type zinc finger domain-containing protein family,was identified as a novel TGF-β target gene in Hep3 B HCC *** of CXXC5 attenuated the expression of a substantial portion of TGF-β target genes and ameliorated TGF-β-induced growth inhibition or apoptosis of Hep3 B cells,suggesting that CXXC5 is required for TGF-β-mediated inhibition of HCC *** of the TCGA database indicated that CXXC5 expression is reduced in the majority of HCC tissue samples in comparison to that in normal ***,CXXC5 associates with the histone deacetylase HDAC1 and competes its interaction with Smad2/3,thereby abolishing the inhibitory effect of HDAC1 on TGF-β *** observations together suggest that CXXC5 may act as a tumor suppressor by promoting TGF-β signaling via a positive feedback loop,and reveal a strategy for HCC to bypass TGF-β-mediated cytostasis by disrupting the positive feedback *** findings shed new light on TGF-β signaling regulation and demonstrate the function of CXXC5 in HCC development.

关键词： hepatocellular carcinoma(HCC) TGF-β CXXC5 HDAC signaling regulation

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Antioxidant Peptide Purified from Enzymatic Hydrolysates of Isochrysis Zhanjiangensis and its Protective Effect against Ethanol Induced Oxidative Stress of HepG2 Cells

Antioxidant Peptide Purified from Enzymatic Hydrolysates of ...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Mei-Fang Chen Yuanyuan Zhang Mei-Di He Cheng-Yong Li Chun-Xia Zhou Peng-Zhi Hong Zhong-Ji Qian College of Food Science and Technology Guangdong Ocean University College of Chemistry and Environment Guangdong Ocean University Shenzhen Institute of Guangdong Ocean University

Marine microalgae have been widely applied in cosmaceuticals,nutraceuticals,and functional *** the present study,we first investigated the hepatoprotective effects of peptide purified from microalgae,Isochrysis zhanjiangensis on HepG2 cells alcoholic *** was hydrolyzed utilizing chymotrypsin,trypsin,pepsin,and by in vitro gastrointestinal *** hydrolysates,the gastrointestinal hydrolysate showed relatively high free radical scavenging ability preliminarily and was purified with following sequential chromatography *** amino acid sequence and molecular mass of the purified peptide from ***(PIZ) was identified as Asn-Asp-Ala-Glu-Tyr-Gly-Ile-Cys-Gly-Phe(NDAEYGICGF;MW,1088.16 Da) via Q-TOF ESI/***,PIZ attenuated ethanol-induced cytotoxicity and inhibited the production of intracellular reactive oxygen species(ROS) by DFCH-DA *** blot results showed that superoxide dismutase(SOD) and glutathione(GSH) levels up-regulated with PIZ treatment before alcohol exposure while gamma-glutamyltransferase(GGT) protein expression *** results provide an opportunity to discover new highly active peptide(PIZ) against alcohol toxicity in HepG2 cells.

关键词： Isochrysis zhanjiangensis Peptide Enzymatic hydrolysates Free radical scavenging Oxidative stress

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SAE1 promotes human glioma progression through activating AKT SUMOylation and AKT signaling pathways

SAE1 promotes human glioma progression through activating AK...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Yanfang Yang Ziwei Liang Xixi Wang Zenghua Sheng Shufang Liang State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center for Biotherapy

The SUMO-activating enzyme SAE1 involves in progression of several human ***,its biological roles of SAE1 in glioma are unknown in previous *** this study,we systematically investigate SAE1 associations with glioma progression in vitro and in ***1 is identified to increase in glioma tissues by a quantitative proteomic dissection,and SAE1 upregulation indicates a high level of tumor malignancy grade and a poor overall survival for glioma ***1 overexpression induces increase of the SUMOylation and Ser473 phosphorylation of AKT and promotes glioma cell growth in vitro and in nude mouse tumor *** the contrary,SAE1 silence induces an obvious suppression of the SUMOylation and Ser473 phosphorylation of Akt,which finally inhibit glioma cell proliferation and the nude mouse tumor growth through inducing cell cycle arrest at G2 phase and cell apoptosis due to serial biochemical molecular events,including CDK2,Cyclin D1,Bcl-2 significantly decreased,and p21,active Caspase-3,Bax ***,SAE1 promotes glioma cancer progression via enhancing Akt SUMOylation-mediated signaling pathways,and SAE1 is a promising prognostic marker and therapeutic target for human glioma.

关键词： Glioma SAE1 SUMOylation Phosphorylation Akt signaling pathway

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Modeling and predicting the activities of trans-acting splicing factors with machining learning

Modeling and predicting the activities of trans-acting splic...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Miaowei Mao Yue Hu Yun Yang Yajie Qian Huanhuan Wei Wei Fan Yi Yang Xiaoling Li Zefeng Wang CAS Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesCAS Center for Excellence in Molecular Cell ScienceChinese Academy of Sciences Synthetic Biology and Biotechnology Laboratory State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science and Technology Signal Transduction Laboratory National Institute of Environmental Health Sciences

Alternative splicing(AS) is generally regulated by trans-splicing factors that specifically bind to cis-elements in *** genome encodes ～1500 RNA binding proteins(RBPs) that potentially regulate AS,yet their function remain largely *** explore their potential activities,we fused the putative functional domains of RBPs to a sequence-specific RNAbinding domain,and systemically analyzed how these engineered factors affect *** discovered that ～80% of low complexity domains in endogenous RBPs displayed distinct context-dependent activities in regulating splicing,indicating that AS is under more extensive regulation than previously *** developed a machine learning approach classify and predict the activities of RBPs based on their sequence compositions,and further validated this model using endogenous RBPs and synthetic *** results represent a systematic inspection,modeling,prediction and validation of how RBP sequences affect their activities in controlling splicing,paving the way for de novo engineering of artificial splicing factors.

关键词： Alternative splicing Splicing factors Machine learning RNA binding domains Protein engineering Protein activity prediction

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