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检索条件"任意字段=中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议"

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RPS3A positively regulates the mitochondrial function of human periaortic adipose tissue and is associated with coronary artery diseases

RPS3A positively regulates the mitochondrial function of hum...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Yan Tang Yi He Chen Li Wenjuan Mu Ying Zou Conghui Liu Shuwen Qian Ju Mei Rong Zeng Qi-qun Tang Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences Fudan University Department of Cardiothoracic Surgery Xinhua HospitalShanghai Jiaotong University of Medicine College Key Laboratory of Systems Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of Sciences

Pericardial adipose tissue,which comprises both epicardial adipose tissue(EAT) and paracardial adipose tissue(PAT),has recently been recognized as a novel factor in the pathophysiology of cardiovascular diseases,especially coronary artery disease(CAD).The goal of this study was to evaluate differences in the brown-like characteristic and proteome among human EAT,PAT and subcutaneous adipose tissue(SAT) to identify candidate molecules causing *** protein 1(UCP-1) and other brown-related proteins were highly expressed in pericardial adipose tissue but was weakly expressed in SAT from the same non-CAD ***,pericardial adipose tissues displayed a higher thermogenesis than ***,brown-related genes were lower in CAD pericardial ***,there were lower levels of metabolic enzymes involved in glycolysis,tricarboxylic acid cycle and fatty acid metabolism in pericardial adipose tissues of *** is an organ adjacent to aortic root without anatomy barriers,which differs from *** found that the expression of ribosomal protein S3 A(RPS3 A) was decreased in human EAT as well as in mouse perivascular adipose tissue(PVAT).Knockdown of RPS3 A significantly inhibited adipocyte differentiation in preadipocytes and impaired the function of mitochondria in mature ***,RPS3 A knockdown in mouse periaortic adipose tissue impaired browning of PVAT,accelerated vascular inflammation and atherosclerosis ***,RPS3 A can migrate to the mitochondria to maintain the function of brown *** findings provide compelling evidence that RPS3 A was a key factor for modulating the brown fat specific gene UCP-1 and carbon metabolic enzymes in EAT for preventing CAD.

关键词： pericardial adipose tissue coronary artery disease RPS3A mitochondria

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Molecular Mechanism for Phosphorylated c-MET Recognition of SHIP2 SH2 Domain Revealed by NMR Spectroscopy

Molecular Mechanism for Phosphorylated c-MET Recognition of ...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Zi Wang Jiang Zhu Yao Nie Rui Hu Maili Liu Yunhuang Yang State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Center for Magnetic ResonanceWuhan Institute of Physics and Mathematicsthe Chinese Academy of Sciences University of Chinese Academy of Sciences

The SH2 domain-containing inositol 5-phosphatase 2(SHIP2) hydrolyzes the 5-phosphate of PtdIns(3,4,5)P3 to produce Ptd Ins(3,4)P2,playing an essential role in hepatocyte growth factor(HGF) induced cell scattering and cell *** role of SHIP2 in cell spreading was suggested to be associated with the binding of SHIP2 with the HGF receptor,c-MET,which is mediated by the SH2 domain of SHIP2 and required the phosphorylation of c-MET at ***,the experimental structure basis and the molecular mechanism for the binding of SHIP2-SH2 with Tyr1356-phosphorylated c-MET had not been *** this study,we determined the solution NMR structure of SHIP2-SH2(PDB ID: 2 MK2) which adopt a typical SH2 domain fold containing a poitively charged ***,the specific interaction between SHIP2-SH2 and a peptide derived from c-MET with phosphorylation at the residue corresponding to Tyr1356 was verified through NMR *** binding affinity was revealed which is in the micromolar level and the interface of binding suggests that the mainly effective region of SH2 is ***,site-directed mutagenes compared with FP assays were performed and the key residues R28,S49 and R70 were identified which may bind to phosphorylated c-MET *** present findings provide a structural explanation for SHIP2-SH2/c-MET interaction and lay a foundation for the possible design of inhibitors to compete for binding to SHIP2-SH2.

关键词： INPPL1 c-MET SH2 domain NMR structure tyrosine phosphorylation

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HDAC2 augments DNA damage-mediated cell death of human osteosarcoma cells through the stimulation of ATM/p53 pathway

HDAC2 augments DNA damage-mediated cell death of human osteo...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Dan Sun Meng Yu Haotian Xing Yuanyuan Li Toshinori Ozaki Yuyan Zhu Department of Urology First Affiliated Hospital of China Medical University Department of Reproductive Biology and Transgenic Animal China Medical University Life Science Institute Saga Medical Center KOSEIKAN Division of Innovative Cancer Therapeutics Chiba Cancer Center Research Institute

To overcome the serious chemo-resistant phenotype of the advanced cancers,it is urgently required to precisely understand the molecular mechanisms behind this *** the present study,we have found that histone deacetylase 2(HDAC2) acts as a co-activator of tumor suppressor p53,and participates in the early molecular events following DNA *** drug adriamycin(ADR) treatment induced cell death in p53-wild-type human osteosarcoma U2 OS cells accompanied by a remarkable accumulation of p53 and γH2 ***2 gene silencing significantly decreased the sensitivity of U2 OS cells to ADR,and obviously attenuated p53-dependent proper DNA damage response such as ADR-mediated phosphorylation of ATM and p53 as well as accumulation of γH2 AX and cleaved ***,HDAC2 knockdown had a marginal effect on p53-null human lung cancer H1299 cells following ADR *** contrast,forced expression of HA-HDAC2 promoted cell death and stimulated the transcriptional activity of ***,p53 and HDAC2 were co-precipitated with ***,our present results strongly suggest that p53/HDAC2 axis plays a vital role in the regulation of proper DNA damage response,and also contributes to chemo-sensitivity of cancer cells.

关键词： Adriamycin Cell death ATM DNA damage HDAC2 p53

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Candida albicans secrete a small cysteine-rich protein Sel1 to trigger TLR2/4-dependent inflammatory response during invasive infection

Candida albicans secrete a small cysteine-rich protein Sel1 ...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Wenjuan Wang Zihou Deng Hongyu Wu Qun Zhao Tiantian Li Wencheng Zhu Xiongjun Wang Chengshu Wang Hui Xiao Jiangye Chen State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell BiologyUniversity of Chinese Academy of SciencesChinese Academy of Sciences CAS Key Laboratory of Molecular Virology & Immunology Institut Pasteur of ShanghaiCAS Center for Excellence in Molecular Cell ScienceUniversity of Chinese Academy of SciencesChinese Academy of Sciences CAS Key Laboratory of Insect Developmental and Evolutionary Biology Shanghai Institute of Plant Physiology and EcologyChinese Academy of Sciences

In spite of being a commensal for healthy individuals,Candida albicans can rapidly switch to pathogenic mode featured with hyphal development,altered cell wall composition and secreted virulence factors,thereby causing mucosal or disseminated candidiasis in immunocompromised *** host relies on a diversity of pattern-recognition receptors,in particular Toll-like receptors(TLRs) and C-type lectin receptors(CLRs) to sense invading fungal pathogens and launch immune defense ***,the complex interplay between fungus and host innate immune system remains incompletely *** we report that Candida albicans upregulate the expression of a small secreted cysteine-rich protein Sel1 upon encountering nitrogen limitation and serum,two hallmarks of human blood,leading to marked proinflammatory ***,Sel1 was able to trigger the activation of signaling pathways NF-B and MAP kinases in macrophages,leading to the expression of a myriad of proinflammatory cytokines and *** genetic analyses revealed that both TLR2 and TLR4 are required for the recognition of Sel1,and TLR2/4-deficient macrophages were blunt in response to Sel1 ***,SEL1-deficient mutant of *** was less efficient in eliciting immune response in vivo,thus causing severer morbidity and mortality in bloodstream infection ***,our results reveal a previous unsuspected mechanism underlying TLRs-mediated immune recognition of ***,hence open a new avenue to tackle candida infection and inflammation.

关键词： Candida albicans secrete a small cysteine-rich protein Sel1 to trigger TLR2/4-dependent inflammatory response during invasive infection

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Effect of Astragalus Polysaccharides on Migration of NSCLC Cells

Effect of Astragalus Polysaccharides on Migration of NSCLC C...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Zhou Yang Lv Xin-yu Zou Shao-jun Gao Yuan Yan Li-jun School of Pharmacy Harbin University of Commerce Institute of Cell and Molecular Biology Harbin University of Commerce

Lung cancer is one of the most common aggressive malignancies and non-small cell lung carcinoma(NSCLC) accounts for 85% of lung cancer-associated *** is common in patients with NSCLC and early metastasis is responsible for a majority that succumb to the *** is a traditional Chinese herbal medicine,with Invigorating qi and consolidating the lungs,tonifying the lung and strengthening the spleen and other *** polysaccharide(APS) is the main component of Astragalus,and its pharmacological effects have enhanced immunity,anti-tumor and so *** studies have shown that APS can inhibit the growth of tumor ***-activated protein kinase kinase kinase kinase 3(MAP4 K3),is a regulator of cell growth,there is evidence that MAP4 K3 is involved in tumor metastasis,viability and ***4 K3 is overexpressed in pulmonary tissues of patients with NSCLC and its overexpression is correlated with high recurrence risk and poor recurrence-free survival *** this study,NSCLC cell line H1299 and H460 was used to investigate the effect of APS on migration and invasion of H1299 and *** treatment of the cells of H1299 and H460 with APS resulted in significant inhibition of this *** cells of H1299 and H460 were transfected with wild-type MAP4 K3 and KD MAP4 K3,and the results were demonstrated that cells transfected with wild-type MAP4 K3 led to more rapid closure of the wounded area compared with the cells transfected with KD MAP4 K3 or the vector ***,overexpression of MAP4 K3 increases the migration and invasion of H1299 and H460 cells,and these effects are reversed by APS ***4 K3 kinase activity was markedly inhibited by ***,MAP4 K3 may be a potential therapeutic target for the treatment of NSCLC.

关键词： APS MAP4K3 migration H1299 cells H460 cells

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PES1 promotes the occurrence and development of papillary thyroid cancer by upregulating the ERα/ERβ protein ratio

PES1 promotes the occurrence and development of papillary th...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Yi-Bo Qiu Ling-Yao Liao Rong Jiang Man Xu Lin-Wan Xu George G.Chen Zhi-Min Liu Department of Biochemistry and Molecular Biology Chongqing Medical University Department of Pathology Molecular Medicine and Cancer Research CenterChongqing Medical University Department of Surgery Chinese University of Hong KongPrince of Wales Hospital

Estrogen has been suggested to play a role in the occurrence and development of papillary thyroid cancer(PTC).The balance and the ratio between ERα and ERβ protein are crucial in determining the effect of estrogen on target tissues and ***1,a BRCT domain-containing protein,has been shown to play a role in modulating the balance and the ratio between ERα and ERβ protein,which is associated with the occurrence and development of breast and ovarian ***,the role of PES1 in connection with the balance and the ratio between ERα and ERβ protein in the occurrence and development of PTC remains *** this study,PES1 protein level in human PTC tissues and cells was examined using immunohistochemistry and Western blotting,*** correlations of PES1 protein level with ERα and ERβ protein levels,with various clinicopathological features of PTC patients,with the ERα/ERβ protein ratio and the proliferation,invasion and migration of PTC cells were assessed using statistical *** results showed that ERα and ERβ were co-expressed in human PTC tissues and ***α promoted and ERβ inhibited the proliferation,invasion and migration of PTC cells and a Yin-Yang balance existed between ERα and ERβ.PES1 modulated this Yin-Yang balance by elevating ERα and reducing ERβ protein level,then upregulating the ERα/ERβ protein ratio and promoting the proliferation,invasion and migration of PTC *** PTC tissues,PES1 protein level positively correlated with ERα(rs = 0.549,P < 0.001) and negatively correlated with ERβ protein level(rs =-0.353,P < 0.001).PES1 and ERα protein levels were gradually increased and ERβ protein level was decreased by degree in the occurrence and development of *** PES1 and ERα and decreased ERβ protein levels correlated with aggressive PTC behaviors such as large tumor size,extrathyroidal extension(ETE),lymph node metastasis(LNM) and high TNM *** was suggested that PES1 promotes the occurrence and development of P

关键词： PES1 ERα ERβ papillary thyroid cancer

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Phosphatase and Actin Regulator 1 Deficiency Decreases Plasma Cholesterol through Endothelial Peroxisome Proliferator-activated Receptor γ Signaling

Phosphatase and Actin Regulator 1 Deficiency Decreases Plasm...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Dongyang Jiang Guofu Zhu Hao Liu Linlin Fan Ze Yu Xu Xu Xiankai Li Shumin Wang Jordan Rhen Xiangbin Xu Yawei Xu Junbo Ge Jinjiang Pang Department of Cardiology Pan-vascular Research InstituteShanghai Tenth People's HospitalTongji University School of Medicine Aab Cardiovascular Research Institute and Department of Medicine University of Rochester School of Medicine and Dentistry

Coronary artery diseases are the leading cause of death,of which abnormal cholesterol level is one of the major risk *** large-scale GWASs(genome-wide association studies) revealed that phosphatase and actin regulator 1(PHACTR1) is highly correlated with coronary artery ***,physiological functions of PHACTR1 in vivo have not been *** generated PHACTR1 knockout mice using CRISPR/Cas9 *** embryo lethal or developmental defects were ***,PHACTR1 deficiency in Apoe-/-mice given a high-fat diet showed significantly decreased plasma cholesterol and low density lipoprotein cholesterol(LDL-C) levels by 23.4% and 40.1%,*** blot demonstrated that PHACTR1 was highly expressed in endothelial cells(ECs) but not detected in liver,adipose tissues,macrophages and vascular smooth muscle *** face staining of aortic artery of Phactr1+/+ mice and immunostaining of HCAECs(human coronary artery endothelial cells) displayed that PHACTR1 localized in endothelial *** investigate the mechanism of endothelial PHACTR1 in cholesterol regulation,RNAseq of aortic ECs was *** enrichment analysis showed that PHACTR1 affected transcription-related biological *** the nuclear location of PHACTR1,transcription factor binding sites analysis were performed,and peroxisome proliferator-activated receptorgamma(PPARγ)/retinoid X receptor(RXRα) was the most relative transcription *** genes of PPARγ involved in cholesterol metabolism were detected by ***36 and Pparg were remarkably increased in Phactr1-/-mouse aortic *** mass spectrometry displayed the interaction of PHACTR1 with HSP90,a modulator of PPARγ *** conclusion,endothelial PHACTR1 is crucial for cholesterol metabolism *** a novel repressor of PPARγ,targeting PHACTR1-PPARγ interaction will be a promising therapeutic strategy for coronary artery diseases.

关键词： PHACTR1 cholesterol metabolism endothelial cell PPARγ

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脐带间充质干细胞分泌因子脂质体囊泡制备及对损伤组织修复作用的研究

脐带间充质干细胞分泌因子脂质体囊泡制备及对损伤组织修复作用的...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者：刘美林傅松涛常冰梅山西医科大学生物化学与分子生物学教研室山西省生物医药健康研究生教育创新中心

背景:研究人脐带间充质干细胞条件培养基制备的脂质体对大鼠皮肤烫伤创面愈合的影响。分离纯化和增殖培养脐带间充质干细胞,收集无动物源性干细胞分泌因子制备成脂质体囊泡,观察脂质体的形态与粒径分布,通过细胞学和动物实验观察其对皮... 详细信息

背景:研究人脐带间充质干细胞条件培养基制备的脂质体对大鼠皮肤烫伤创面愈合的影响。分离纯化和增殖培养脐带间充质干细胞,收集无动物源性干细胞分泌因子制备成脂质体囊泡,观察脂质体的形态与粒径分布,通过细胞学和动物实验观察其对皮肤创伤的修复作用和生物安全性,为创伤治疗提供新型干细胞基质制剂并对其作用机理和安全性进行初步的探讨和评估。方法:1.脐带组织贴壁法分离纯化和传代培养hUC-MSC,观察其形态,并对其表面标记物和成脂肪细胞、成骨细胞分化能力进行检测。2.收集无动物源性hUC-MSC分泌因子(条件培养液),通过ELISA法对收集的条件培养基进行VEGF、IL-8、MCP-1因子的定量测定。3.用薄膜分散法制备hUC-MSC因子脂质体囊泡,对其进行电镜下超微形态的观察和粒径分布特征的测定。4.通过动物实验观察hUC-MSC条件培养液及其脂质体对大鼠皮肤缺损模型的创伤修复作用,进一步对其有效性、作用机理和安全性进行探讨和评估。结果:1.光镜下,hUC-MSC呈大小形态均一的长梭型旋涡状,流式细胞仪检测hUC-MSC阳性标志物CD29、CD44、105的表达率均≥95%,阴性标志物CD34、CD45的表达率≤5%,且hUC-MSC可被诱导分化为脂肪细胞和骨细胞。***-MSC条件培养液中含有干细胞分泌因子,在P5代时,蛋白浓度为0.145mg/mL,经考马斯亮蓝染色有蛋白条带出现,经ELISA测定,条件培养液中VEGF、IL-8、MCP-1的浓度分别为558.60 pg/mL、5236.48pg/mL、2972.55pg/mL;而空白培养基中,蛋白含量为0.002 mg/mL,因子VEGF、IL-8、MCP-1的浓度分别为0.000 pg/mL、0.000pg/mL、0.000pg/mL。3.用薄膜分散法制备得到hUC-MSC分泌因子脂质体,其粒径呈拟正态分布,粒径范围在37.84nm～3580.00nm,平均粒径为262.3nm;电镜下,hUC-MSC分泌因子脂质体呈不规则的圆球状,大小不均一,但分散比较均匀。4.大鼠皮肤创口修复实验表明,hUC-MSC条件培养基液和其脂质体制剂均可以促进创伤的修复,创口及周边组织石蜡切片HE染色后,光镜下观察可见:空白对照组与空白脂质体对照组,创面修复缓慢,真皮层及创面深层未见腺体和毛囊生成,有组织水肿;干细胞分泌因子组,早期大鼠皮肤创面有肉芽组织生成,大鼠皮肤表皮层加厚,真皮层创面肉芽组织增加,有大量新生血管,创面下腺体与毛囊增多;hUC-MSC分泌因子脂质体组,早期大鼠皮肤创面有肉芽组织生成,表皮层加厚大鼠皮肤创面肉芽组织增加,有大量新生血管生成,创面下及皮肤深层的腺体与毛囊增多。结论:1.贴壁培养法可获得高纯度且形态均一的hUC-MSC。2.可用无血清的基础培养基获得无动物源性的干细胞分泌因子(条件培养基)。3.干细胞分泌因子及其脂质体囊泡均可促进大鼠皮肤缺损的创伤修复。

关键词：人脐带间充质干细胞干细胞分泌因子脂质体囊泡创伤修复

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GSK3 contributes to obesity-induced adipose tissue inflammation by regulating AIM/CD5L mediated macrophage migration

GSK3 contributes to obesity-induced adipose tissue inflammat...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Li Wang Yuan Wang Chao Zhang Jingjing Li Yuan Meng Lijun Di Metabolomics Core Faculty of Health SciencesUniversity of Macau

Obesity-induced inflammation in white adipose tissue,characterized by increased macrophage infiltration and associated with macrophage population shift from anti-inflammatory M2 to proinflammatory M1 macrophages,largely contributes to obesity-induced insulin resistance and influences T2 DM ***3,a serine/threonine kinase,has been reported to participate in various cellular *** sought to examine the potential mechanism by which GSK3,a serine/threonine kinase implaicated in various cellular processes,modulates obesity-induced visceral adipose tissue(VAT) *** C57 BL/6 J mice were fed a high-fat diet for 10 weeks while being treated with control or GSK3 ***-Sequencing results using VAT demonstrated that GSK3 inhibitor treatment reversed obesity-specific expression of genes associated with ***,GSK3 inhibition reduced M1 macrophages and increased M2 macrophages in VAT,while decreasing inflammatory *** anti-inflammatory effects of GSK3 inhibition were found to be driven,at least in part,by inhibiting production of apoptosis inhibitor of macrophage(AIM) in macrophages via inactivating STAT3 to reduce free fatty acid and chemokine level produced from VAT to suppress circulatory monocyte *** findings suggest that GSK3 may act as an important regulator of obesity-induced inflammation and characterize the novel role of GSK3 in shifting macrophage polarization and reinforce its therapeutic potential for obesity-induced inflammation and its associated diabetes.

关键词： Obesity Inflammation Macrophage Insulin resistance GSK3/AIM

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DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation

DKK2 imparts tumor immunity evasion through β-catenin-indep...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Qian Xiao Jibo Wu Wei-Jia Wang Shiyang Chen Yingxia Zheng Xiaoqing Yu Katrina Meeth Mahnaz Sahraei Alfred L M Bothwell Lieping Chen Marcus Bosenberg Jianfeng Chen Veronika Sexl Le Sun Lin Li Wenwen Tang Dianqing Wu Vascular Biology and Therapeutic Program and Department of Pharmacology Yale School of Medicine State Key Laboratory of Molecular Biology CAS Center for Excellence in Molecular Cell ScienceInnovation Center for Cell Signaling NetworkInstitute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesUniversity of Chinese Academy of Sciences State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of Sciences Biostatistics Department Yale University Departments of Dermatology and Pathology Yale School of Medicine Department of Immunobiology Yale School of Medicine Yale Cancer Center Yale School of Medicine Institute of Pharmacology and Toxicology Department for Biomedical SciencesUniversity of Veterinary Medicine Vienna AbMax

Immunotherapy offers new options for cancer treatment,but efficacy varies across cancer *** cancers(CRCs) are largely refractory to immune-checkpoint blockade,which suggests the presence of yet uncharacterized immunesuppressive *** we report that the loss of adenomatosis polyposis coli(APC) in intestinal tumor cells or of the tumor suppressor PTEN in melanoma cells upregulates the expression of Dickkopf-related protein 2(DKK2),which,together with its receptor LRP5,provides an unconventional mechanism for tumor immune ***2 secreted by tumor cells acts on cytotoxic lymphocytes,inhibiting STAT5 signaling by impeding STAT5 nuclear localization via LRP5,but independently of LRP6 and the Wnt–b-catenin *** or antibody-mediated ablation of DKK2 activates natural killer(NK) cells and CD8+T cells in tumors,impedes tumor progression,and enhances the effects of PD-1 ***,we have identified a previously unknown tumor immune-suppressive mechanism and immunotherapeutic targets particularly relevant for CRCs and a subset of melanomas.

关键词： Immunotherapy DKK2 STAT5 LRP5(Times New Roman,12 points)

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