Transforming growth factor-β(TGF-β) signaling inhibits cell proliferation to block cancer initiation,while enhancing metastasis to promote malignancy during breast cancer *** addition,HER2/EGFR signaling has been sh...
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Transforming growth factor-β(TGF-β) signaling inhibits cell proliferation to block cancer initiation,while enhancing metastasis to promote malignancy during breast cancer *** addition,HER2/EGFR signaling has been shown to collaborate with TGF-β to promote cancer ***,the underlying mechanisms are still *** this talk,I will discuss how HER2/EGFR signaling may switch TGF-β function in breast cancer cells from anti-proliferation to cancer *** found that inhibition of HER2/EGFR activity attenuates TGF-β-induced epithelial-mesenchymal transition and migration,but enhances the anti-proliferative activity of TGF-β.Activation of HER2/EGFR signaling promotes the nuclear accumulation of Smad3 and then activates the expression of the genes related to EMT and cell migration.
Brown and beige fat generate heat by expending chemical energy and are important in controlling body temperature and body *** of development and function of brown and beige fat contribute to the development of ***,we ...
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Brown and beige fat generate heat by expending chemical energy and are important in controlling body temperature and body *** of development and function of brown and beige fat contribute to the development of ***,we show that fat PNPLA7,a Patatin-Like Phospholipase Domain-Containing protein 7,expression is markedly increased in ob/ob mice and reduced by cold *** of PNPLA7 in adipose tissue impairs the thermogenic function of brown adipocytes,decreased core body temperature,and cold ***,overexpression of PNPLA7 inhibites the browning of white adipose tissue(WAT) following cold exposure or β3-agonist ***,knockdown of PNPLA7 in primary fat cells stimulates the thermogenic *** present study reveals a critical role of PNPLA7 in the regulation of thermogenesis of fat which may provide novel pharmaceutical target for prevention and treatment of obesity and metabolic diseases.
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