Objective To study the method that could be used to identify aspergilli within *** 124 aspergillus isolates were collected in Medical University Affiliated Beijing Tongren *** were identified by morphology and molecul...
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Objective To study the method that could be used to identify aspergilli within *** 124 aspergillus isolates were collected in Medical University Affiliated Beijing Tongren *** were identified by morphology and molecular *** first one included traditional culture, spring and stain,and *** second one was that identified these isolates using the part of ITS(the internal transcribed spacer region of the rRNA gene) andβ-tubulin gene,by thenamplification and sequencing,and analyzing all the sequences in the GenBank(http://***), European Molecular Biology Laboratory nucleotide sequence
Protein tyrosine phosphatases(PTPs) consist of a large family of signaling enzymes known to play important roles in controlling virtually all aspects of cellular processes. Deregulation of PTP activity results in aber...
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Protein tyrosine phosphatases(PTPs) consist of a large family of signaling enzymes known to play important roles in controlling virtually all aspects of cellular processes. Deregulation of PTP activity results in aberrant tyrosine phosphorylation,which has been linked to the etiology of several human ***,the PTP family provides an exciting array of validated but previously deemed undruggable infectious disease,diabetes,autoimmunity and oncology *** the contributing factors to the failure of drug discovery in the PTP field is the
Objective To study genotypic and biological character of MRSE isolates associated with catheter,providing information for the diagnosis and prevention of catheterrelated bloodstream *** To collect the MRSE isolates as...
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Objective To study genotypic and biological character of MRSE isolates associated with catheter,providing information for the diagnosis and prevention of catheterrelated bloodstream *** To collect the MRSE isolates associated with catheter from January 2006 to December 2009 in Beijing Tongren Hospital.A total of 30 isolates underwent MLST,PCR for icaA gene(encoding the polysaccharide intercellular adhesion associated with pathogenicity) and agar diffusion method for drug sensitivity
Enzymatic catalysis of biochemical reactions is essential to all living *** "lock and key" and "induced fit" models were early contributions to our understanding of the mechanisms involved in the r...
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Enzymatic catalysis of biochemical reactions is essential to all living *** "lock and key" and "induced fit" models were early contributions to our understanding of the mechanisms involved in the reaction between an enzyme and its ***,whether a given substrateinduced conformation is rigid or remains flexible has not yet been *** measuring the enzyme activity and intrinsic fluorescence of a nonspecific Eisenia fetida protease-I with different chromogenic substrates,we show that in subsequent reactions of protease with substrates,both
The Hfq protein is reported to be an RNA chaperone,which is involved in stress response and virulence of several *** ***,Hfq can mediate the interaction between some sRNAs and their target *** it is controversial whet...
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The Hfq protein is reported to be an RNA chaperone,which is involved in stress response and virulence of several *** ***,Hfq can mediate the interaction between some sRNAs and their target *** it is controversial whether Hfq plays an important role in S. *** this study,it is found that the deletion of hfq gene in *** 8325-4 can induce the surface carotenoid pigments *** hfq mutant is more resistant to the oxidative stress,but the pathogenicity of the mutant is *** reveal that the Hfq protein can be detected
MiRNA activity was found suppressed in mouse oocytes,so we wanted to know whether it was so during porcine oocyte *** found that miRNA expression profiling was dynamic changed in porcine oocytes cultured in vitro (IVM...
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MiRNA activity was found suppressed in mouse oocytes,so we wanted to know whether it was so during porcine oocyte *** found that miRNA expression profiling was dynamic changed in porcine oocytes cultured in vitro (IVM) for different *** all the differently expressed miRNAs were upregulated when comparing mature oocytes with *** these miRNAs miR-21 expression was down regulated after GVBD,while up regulated
Gastric careinoma is one of the most serious malignant tumors threatening people's life and health in our *** is of great importantce to understand the molecular mechanism of gastric careinoma occurrence and *** o...
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Gastric careinoma is one of the most serious malignant tumors threatening people's life and health in our *** is of great importantce to understand the molecular mechanism of gastric careinoma occurrence and *** oxygenase-l(HO-l),also called heat shock protein 32(HSP32),is the rate-limiting enzyme that catalyzes the conversion of heme to biliverdin,carbon monoxide(CO) and *** has been demonstrated that HO-1 were related to the
In eukaryotic cells,autophagy is a highly conserved selfdigestion process to promote cell survival in response to nutrient starvation and other metabolic *** is regulated by cell signaling such as the mTOR pathway. Ho...
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In eukaryotic cells,autophagy is a highly conserved selfdigestion process to promote cell survival in response to nutrient starvation and other metabolic *** is regulated by cell signaling such as the mTOR pathway. However,the significance of autophagy in modulation of signal transduction is *** we show that autophagy negatively regulates Wnt signaling by promoting Dishevelled (Dv1) degradation,von Hippel-Lindau protein-mediated ubiquitination is critical for Dvl2 to bind to p62,which
Obesity has reached epidemic proportions,and complications related to obesity contribute substantially to health care costs and *** accumulation of fat is the net result of a prolonged state of imbalance between energ...
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Obesity has reached epidemic proportions,and complications related to obesity contribute substantially to health care costs and *** accumulation of fat is the net result of a prolonged state of imbalance between energy intake and energy *** adipose tissue represents a natural target for the modulation of energy expenditure. This tissue is far from being a fat *** activated,it requires the uptake of substrate from the circulation,mostly free fatty acids,but also *** brown adipose tissue,
Profilin-l(PFNl),a ubiquitously expressed regulator of actin dynamics,has been found to act as a tumor suppressive protein because of its downregulated expression level in various kinds of cancer cells and its impairi...
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Profilin-l(PFNl),a ubiquitously expressed regulator of actin dynamics,has been found to act as a tumor suppressive protein because of its downregulated expression level in various kinds of cancer cells and its impairing ability on tumorigenesis and carcinoma aggressiveness when overexpressing the ectopic *** until now the mechanisms for PFN1 exerting tumor inhibition remain *** objective of the present study was to explore the involvement of PFN1 in tumor suppressive *** years there is growing evidence revealing that,apart from actin binding,PFN1 also interacts with a plethora of proteins
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