Integrin-mediated cell-extracellular matrix(ECM)adhesion is a fundamental process that controls a variety of processes including cell migration,proliferation and *** of cell-extracellular matrix adhesion and signaling...
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Integrin-mediated cell-extracellular matrix(ECM)adhesion is a fundamental process that controls a variety of processes including cell migration,proliferation and *** of cell-extracellular matrix adhesion and signaling are intimately associated with the pathogenesis and progression of human ***,elucidating the molecular basis underlying integrin-mediated
Inflammatory processes in the body can be triggered not only in response to external signals,but also in response to the release of endogenous molecules called damage-associated molecular *** such molecule,the small l...
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Inflammatory processes in the body can be triggered not only in response to external signals,but also in response to the release of endogenous molecules called damage-associated molecular *** such molecule,the small leucine-rich proteoglycan biglycan,is ubiquitously distributed in the body and can be proteolytically released from the extracellular matrix following tissue *** its solubleform,biglycan acts as a ligand of
Bone formation is a complex process in which osteogenic differentiation of MSCs is a major *** osteogenesis MSCs confront multiple energy consuming metabolic processes such as new protein synthesis for matrix formatio...
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Bone formation is a complex process in which osteogenic differentiation of MSCs is a major *** osteogenesis MSCs confront multiple energy consuming metabolic processes such as new protein synthesis for matrix formation and *** found an important nexus where protein synthesis master regulator mTOR affects ERRa transcriptional activity inducing the expression of a novel target Glutaminase to ramp up
Epidemiology studies have identified aging as is a predominant risk factor that accelerates the pathogenesis of cardiovascular diseases,the leading cause of mortality and mobility in the United States and *** aging,th...
Epidemiology studies have identified aging as is a predominant risk factor that accelerates the pathogenesis of cardiovascular diseases,the leading cause of mortality and mobility in the United States and *** aging,the age-related structural changes in the blood vessels,not only impair normal vascular contraction and compliance but also increase the incidence of cardiovascular disease,including hypertension,atherosclerosis and
Osteoarthritis(OA)is the most prevalent and debilitating joint disease,and there are currently no effective disease-modifying treatments *** risk factors for OA,such as aging,result in progressive damage and loss of a...
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Osteoarthritis(OA)is the most prevalent and debilitating joint disease,and there are currently no effective disease-modifying treatments *** risk factors for OA,such as aging,result in progressive damage and loss of articular *** circadian clocks have been identified in mouse cartilage,and environmental disruption of circadian rhythms in mice predisposes to OA-like ***,the contribution of the cartilage clock mechanisms to the maintenance of tissue homeostasis is still ***,we have shown
Basement membranes(BMs)are polymers of ECM proteins underlying epithelia and surrounding organs in all *** my laboratory,we are working to understand the biology of BMs using the fruitfly Drosophila melanogaster as a ...
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Basement membranes(BMs)are polymers of ECM proteins underlying epithelia and surrounding organs in all *** my laboratory,we are working to understand the biology of BMs using the fruitfly Drosophila melanogaster as a model organism,mostly through genetics and cell biology *** my talk,I will present our findings regarding the secretion of Collagen IV,the hierarchy of assembly of BM components and the
The longitudinal growth of long bone requires proximal-distal elongation of the cartilaginous ***,the mechanism underlying directional elongation of the long bone cartilage is *** cell polarity(PCP)is an evolutionaril...
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The longitudinal growth of long bone requires proximal-distal elongation of the cartilaginous ***,the mechanism underlying directional elongation of the long bone cartilage is *** cell polarity(PCP)is an evolutionarily conserved essential mechanism that provides directional information to control and coordinate polarized cellular and tissue behaviors during embryonic *** of PCP leads to
Appropriate interactions of T cells and extracellular matrix and/or antigen presenting cells initiate adaptive immune responses to prevent biological system from pathogenic *** membrane receptors on T cells,including ...
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Appropriate interactions of T cells and extracellular matrix and/or antigen presenting cells initiate adaptive immune responses to prevent biological system from pathogenic *** membrane receptors on T cells,including integrins and T cell receptor(TCR),mediateT-cell adhesion,antigen recognition and T-cell *** force is known to regulate receptors'biological *** this talk,I will introduce our progress on
Tumor necrosis factor(TNF)superfamily member 11(TNFSF11,also known as RANKL)regulates multiple physiological or pathological functions,including osteoclast differentiation and ***11A(also called RANK)is considered to ...
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Tumor necrosis factor(TNF)superfamily member 11(TNFSF11,also known as RANKL)regulates multiple physiological or pathological functions,including osteoclast differentiation and ***11A(also called RANK)is considered to be the sole receptor for *** we report that leucine-rich repeat-containing G-protein-coupled receptor 4(LGR4,also called GPR48)is another receptor
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