Under different physiological and pathological conditions,platelets can dynamically interact with subendothehalextracellular matrix proteins such as von Willebrand factor(vWF),collagen,fibrinogen,fibronectin and *** m...
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Under different physiological and pathological conditions,platelets can dynamically interact with subendothehalextracellular matrix proteins such as von Willebrand factor(vWF),collagen,fibrinogen,fibronectin and *** major adhesion receptors such as integrin αⅢbβ3,α2β1 and αVβ3,GPVI and GPⅠb-Ⅸ-Ⅴcomplex have been identified to highly express at the surface of *** these receptors can be activated by
Vascular graft has proven to be an effective strategy for the treatment of cardiovascular *** grafts made solely from synthetic polymers cannot satisfy the clinic requirements in terms of low long-term patency,because...
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Vascular graft has proven to be an effective strategy for the treatment of cardiovascular *** grafts made solely from synthetic polymers cannot satisfy the clinic requirements in terms of low long-term patency,because they only provide a simple structural or physical replacement without the biological *** order to resolve this problem,we aim to fabricate vascular grafts which could mimic native extracellular
Periostin,a novel matricellular protein,plays an important role in the inflammatory microenvironment in various disorders such as tissue injure,skin inflammation,atherosclerosis,asthma and lung *** has also been repor...
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Periostin,a novel matricellular protein,plays an important role in the inflammatory microenvironment in various disorders such as tissue injure,skin inflammation,atherosclerosis,asthma and lung *** has also been reported to be a critical contributor in several tumor microenvironments including cancer stem cell niche,perivascular niche and fibrotic metastatic *** recent work demonstrates that periostin contributes to hepatic
Several studies have implicated the angiotensin Ⅱtype 1 receptor（AT1r）in the development of thoracic aortic aneurysm（TAA）in murine models of the disease,including those afflicted with Marfan syndrome（MFS）.We re...
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Several studies have implicated the angiotensin Ⅱtype 1 receptor（AT1r）in the development of thoracic aortic aneurysm（TAA）in murine models of the disease,including those afflicted with Marfan syndrome（MFS）.We recently investigated how AT1r expressed on either endothelial cells（ECs）or smooth muscle cells（SMCs）influence TAA formation in Fbn1mice,a validated animal model of early onset progressively severe
Acute kidney injury(AKI)is defined as an abrupt deterioration in kidney *** effects of AKI on cerebrovascular function is poorly *** we tested the hypothesis that AKI may promote strokes by cerebrovascular sensitizati...
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Acute kidney injury(AKI)is defined as an abrupt deterioration in kidney *** effects of AKI on cerebrovascular function is poorly *** we tested the hypothesis that AKI may promote strokes by cerebrovascular sensitization to angiotensinⅡ(AngⅡ)in conjunction with FGF2(fibroblast growth factor 2)plus the secreted FGF binding protein *** ischemia-reperflision mice served as the AKI model and
Matrix-integrin activation triggers cell *** development at integrins can differentially regulate signal transduction at the cell-matrix interface,and viscous RGD membrane provides a unique substrate to study force-de...
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Matrix-integrin activation triggers cell *** development at integrins can differentially regulate signal transduction at the cell-matrix interface,and viscous RGD membrane provides a unique substrate to study force-dependentadhesion *** previously revealed that clustering of integrin-beta3 recruited endocytic proteins Dab2 and clathrin,and developed podosomes in the absence of matrix traction ***,the functional link between podosome and integrin endocytosis remains ***,we use labeled RGD peptides as
Hepatic fibrosis is caused by chronic liver injury and may progress toward liver cirrhosis,and even hepatocellular ***,current treatment is not ***,there is a mandate to find novel therapeutic targets to improve thera...
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Hepatic fibrosis is caused by chronic liver injury and may progress toward liver cirrhosis,and even hepatocellular ***,current treatment is not ***,there is a mandate to find novel therapeutic targets to improve therapy,and biomarkers to monitor therapeutic ***,we reported that collagen triple helix repeat containing 1(CTHRC1),a secreted protein derived from hepatic stellate cells(HSCs),
Genetic screening identifies the atypical tetraspanin TM4SF1 as a strong mediator of metastatic reactivation of breast ***,TM4SF1 couples the collagen receptor tyrosine kinase DDR1 to the cortical adaptor syntenin 2 a...
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Genetic screening identifies the atypical tetraspanin TM4SF1 as a strong mediator of metastatic reactivation of breast ***,TM4SF1 couples the collagen receptor tyrosine kinase DDR1 to the cortical adaptor syntenin 2 and,hence,to PKCα.The latter kinase phosphorylates and activates JAK2,leading to the activation of *** non-canonical mechanism of signaling induces the expression of SOX2 and NANOG;sustains the
Based on literatures and our previous study we hypothesize that the epigenetic mechanisms such as DNA methylation and miRNAs are involved in the regulation of bone formation during cellular stress response and homeost...
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Based on literatures and our previous study we hypothesize that the epigenetic mechanisms such as DNA methylation and miRNAs are involved in the regulation of bone formation during cellular stress response and homeostasis in the early phase of bone repair materials *** the early stage of implantation of different materials in the porcine spinal fusion model and the chondrogenic differentiation of hBMSCs,we used gene chip
High coverage and quantitative proteomics has been becoming one of powerful tool in life *** dissected the extracellular matrix(ECM)during the development of liver cirrhosis,and found that the collagens upregulated in...
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High coverage and quantitative proteomics has been becoming one of powerful tool in life *** dissected the extracellular matrix(ECM)during the development of liver cirrhosis,and found that the collagens upregulated in cirrhosis ***,a series of fragments derived from collagens were identified with high coverage proteomics *** biological function of these fragments was also explored.
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