Osteoarthritis(OA)is the most prevalent and debilitating joint disease,and there are currently no effective disease-modifying treatments *** risk factors for OA,such as aging,result in progressive damage and loss of a...
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Osteoarthritis(OA)is the most prevalent and debilitating joint disease,and there are currently no effective disease-modifying treatments *** risk factors for OA,such as aging,result in progressive damage and loss of articular *** circadian clocks have been identified in mouse cartilage,and environmental disruption of circadian rhythms in mice predisposes to OA-like ***,the contribution of the cartilage clock mechanisms to the maintenance of tissue homeostasis is still ***,we have shown
Inflammatory processes in the body can be triggered not only in response to external signals,but also in response to the release of endogenous molecules called damage-associated molecular *** such molecule,the small l...
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Inflammatory processes in the body can be triggered not only in response to external signals,but also in response to the release of endogenous molecules called damage-associated molecular *** such molecule,the small leucine-rich proteoglycan biglycan,is ubiquitously distributed in the body and can be proteolytically released from the extracellular matrix following tissue *** its solubleform,biglycan acts as a ligand of
Integrin activation is an indispensable step for various integrin-mediated biological ***-2 is known to co-activate integrins with Talin,however,molecules that restrict integrin activation are ***,we demonstrate that ...
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Integrin activation is an indispensable step for various integrin-mediated biological ***-2 is known to co-activate integrins with Talin,however,molecules that restrict integrin activation are ***,we demonstrate that the E3 ubiquitin ligase Smurf1 controls the amount of Kindlin-2 protein in cells and hinders integrin ***1 interacts with and promotes Kindlin-2 ubiquitination and ***
Epidemiology studies have identified aging as is a predominant risk factor that accelerates the pathogenesis of cardiovascular diseases,the leading cause of mortality and mobility in the United States and *** aging,th...
Epidemiology studies have identified aging as is a predominant risk factor that accelerates the pathogenesis of cardiovascular diseases,the leading cause of mortality and mobility in the United States and *** aging,the age-related structural changes in the blood vessels,not only impair normal vascular contraction and compliance but also increase the incidence of cardiovascular disease,including hypertension,atherosclerosis and
Integrin-mediated cell-extracellular matrix(ECM)adhesion is a fundamental process that controls a variety of processes including cell migration,proliferation and *** of cell-extracellular matrix adhesion and signaling...
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Integrin-mediated cell-extracellular matrix(ECM)adhesion is a fundamental process that controls a variety of processes including cell migration,proliferation and *** of cell-extracellular matrix adhesion and signaling are intimately associated with the pathogenesis and progression of human ***,elucidating the molecular basis underlying integrin-mediated
Tumor necrosis factor(TNF)superfamily member 11(TNFSF11,also known as RANKL)regulates multiple physiological or pathological functions,including osteoclast differentiation and ***11A(also called RANK)is considered to ...
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Tumor necrosis factor(TNF)superfamily member 11(TNFSF11,also known as RANKL)regulates multiple physiological or pathological functions,including osteoclast differentiation and ***11A(also called RANK)is considered to be the sole receptor for *** we report that leucine-rich repeat-containing G-protein-coupled receptor 4(LGR4,also called GPR48)is another receptor
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