Mu-opioid receptors(MORs) are crucial for analgesia by both exogenous and endogenous ***, the neuronal population mediating the effects of these two types of opioid analgesia remains largely ***, we demonstrate that d...
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Mu-opioid receptors(MORs) are crucial for analgesia by both exogenous and endogenous ***, the neuronal population mediating the effects of these two types of opioid analgesia remains largely ***, we demonstrate that distinct neuronal populations mediate analgesic effects of exogenous and endogenous opioids on chronic *** found that the exogenous morphine-induced analgesia of chronic inflammatory pain is mediated by MORs in glutamatergic but not GABAergic *** contrast, analgesia due to endogenous opioids is mediated by MORs in GABAergic rather than glutamatergic ***,MORs expressed in glutamatergic neurons of parabrachial nucleus contribute significantly to analgesia due to exogenous but not endogenous ***, our study demonstrates that the MORs expressed in excitatory and inhibitory neurons in different brain regions play differential roles in opioid analgesia, indicating distinct circuits underlying pain modulation by exogenous *** opioids.
脓毒症(Sepsis)是感染诱发的以多脏器衰竭为特征的危急重症,具有起病急和病情重的特点,死亡率高达40%。学术界过去认为造成脓毒症多脏器衰竭和死亡的主要原因是感染诱发的"炎症因子风暴",因此开展了大量临床试验尝试通过抑制全身炎症反应来控制脓毒症,然而这些临床试验结果均显示:抑制经典炎症反应的治疗方案并不能改善脓毒症症状和降低患者的死亡率——表明"炎症因子风暴"理论在解释脓毒症的发病机制方面存在一定的局限性。近年来国际顶级杂志发表一系列论文,揭示了脓毒症发病机制研究的新突破:半胱氨酸天冬氨酸特异性蛋白水解酶-11 (cysteinyl aspartate specific proteinase-11,Caspase-11)介导的细胞焦
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