Objeetive:Recurrent stroke is common with no *** systemic interleukin-10(IL-10)has cytoprotective effects for stroke,it has significant side effect of suppressing systemic immune *** term forced increase in systemic I...
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Objeetive:Recurrent stroke is common with no *** systemic interleukin-10(IL-10)has cytoprotective effects for stroke,it has significant side effect of suppressing systemic immune *** term forced increase in systemic IL-10 is not an applicable strategy for unexpected future insults including recurrent stroke.
Aim:Intermedin iS known as adrenomedullin 2,a novel member of the calcitonin gene-related peptide family,can cause different cardiovascular effects by systemical or brain *** present study is designed to determine the...
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Aim:Intermedin iS known as adrenomedullin 2,a novel member of the calcitonin gene-related peptide family,can cause different cardiovascular effects by systemical or brain *** present study is designed to determine the effects of intermedin on sympathetic nerve activity and its related molecular mechanism in the nucleus tractus solitarii(NTS).
Aim:The rostral ventrolateral medulla(RVLM)plays a critical role in control of cardiovascular *** increased glutamatergic synaptic transmission in the RVLM contributes to high levels of blood pressure and sympathetic ...
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Aim:The rostral ventrolateral medulla(RVLM)plays a critical role in control of cardiovascular *** increased glutamatergic synaptic transmission in the RVLM contributes to high levels of blood pressure and sympathetic outflow in hypertensive ***,it has been suggested that angiotensin-converting enzyme 2 (ACE2)is beneficial to cardiovascular dysfunction in the spontaneously hypertensive rat (SHR).Thus,the aim of this study Was to determine the effect of ACE2 9ene transfer to
Objecfive:Increase of 20-HETE in blood has been reported to be attributable to shortened bleeding time and platelet aggregation,but the involvement of relevant factors is largely *** present study is aiming to investi...
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Objecfive:Increase of 20-HETE in blood has been reported to be attributable to shortened bleeding time and platelet aggregation,but the involvement of relevant factors is largely *** present study is aiming to investigate whether administration of 20-HETE causes endothelial dysfunction and subsequently increases blood coagulation. Methods:We treated human umbilical vein endothelial cells(HUVECs)with
Adenosine。triphosphate(ATP)is composed of the nucleobase adenine.L-type Ca channel(LTCC)is a type of voltage-dependent calcium *** plays a vital role in regulmion of *** is generally accepted that ATP in regulati...
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Adenosine。triphosphate(ATP)is composed of the nucleobase adenine.L-type Ca channel(LTCC)is a type of voltage-dependent calcium *** plays a vital role in regulmion of *** is generally accepted that ATP in regulation of cardiac L-type Ca channel(Cav l.2)activities involves protein ***,several studies demonstrate that the protein phosphorylation-independent pathway also involves in the
objective:Current study determined whether thioredoxin reductase(TrxR)was altered in the aging heart in a way that may involved in increased susceptibility to myocardial ischemia/reperfusion injury(M1/R)and investigat...
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objective:Current study determined whether thioredoxin reductase(TrxR)was altered in the aging heart in a way that may involved in increased susceptibility to myocardial ischemia/reperfusion injury(M1/R)and investigated the potential mechanisms. Method and results:Male aged or adult rats were subjected t0 30 min of myocardial ischemia followed by reperfusion 3 hours and treated with vehicle or
Objective:Severe vascular hyporesponsiveness in septic shock is a critical factor that causes refractory hypotension and interferes with the treatment of theses patients. Our previous study found that arginine vasopre...
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Objective:Severe vascular hyporesponsiveness in septic shock is a critical factor that causes refractory hypotension and interferes with the treatment of theses patients. Our previous study found that arginine vasopressin(AVP)could improve the vascular reactivity in hemorrhagic *** present study was aimed to investigate if AVP and
Aims:Rhynchophylline(Rhy),indole alkaloids from Uncaria hooks,reportedly exert hypotensive and vasodilatory effects,but the mechanism of action is *** therefore investigated the relaxant effects of Rhy in rat mesent...
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Aims:Rhynchophylline(Rhy),indole alkaloids from Uncaria hooks,reportedly exert hypotensive and vasodilatory effects,but the mechanism of action is *** therefore investigated the relaxant effects of Rhy in rat mesenteric arteries in vitro,in particular in respect of its effect on intracellular Cachanges in single smooth muscle cells(SMCs). Methods:We examined the effect of Rhy on the precontracted artery by tension
Objecfive:Local injection of induced pluripotent stem cells(iPS)ameliorates stroke along with teratoma formation and mechanic *** hypothesize that intravenously administration may disseminate iPS in the tissues of tar...
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Objecfive:Local injection of induced pluripotent stem cells(iPS)ameliorates stroke along with teratoma formation and mechanic *** hypothesize that intravenously administration may disseminate iPS in the tissues of target and therefore avoid teratoma formation while retaining therapeutic ***-221 and miR-320 involves in cell adhesion,migration and *** may regulate iPS *** present study observes the effect of intravenous injected iPS on brain ischemia/reperfusion injury and
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