Aim and Method:To study the charactertistic brain abnormalities at the early stage of epilepsy,we applied chronic(n=19)or acute(n=9)electrogenic epilepsy model by delivering repetitivetetani into the right dorsal ...
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Aim and Method:To study the charactertistic brain abnormalities at the early stage of epilepsy,we applied chronic(n=19)or acute(n=9)electrogenic epilepsy model by delivering repetitivetetani into the right dorsal hippocampus(DHPC)in *** chronic epilepsy models,rats receivedtetanization once a day for 2,4,6,8 or 10 days and were observed both by T weighted magneticresonance image(T-WI)and by histologic *** acute experiments,ten trains were repeat-
Arterial vessels express one or more HO isoenzymes which catalyze the metabolism of heme toCO and *** promotes vasorelaxation via mechanisms that,depending on the vessels,in-volve activation of soluble guanylate cycla...
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Arterial vessels express one or more HO isoenzymes which catalyze the metabolism of heme toCO and *** promotes vasorelaxation via mechanisms that,depending on the vessels,in-volve activation of soluble guanylate cyclase,stimulation of calcium-activated potassium channels,ordiminished synthesis of constrictor mediators,viz.,endothelin and *** of HO elic-it vasoconstriction in vivo and in isolated pressurized *** of HO also enhance myo-
Increasing Ca inhibited the apical 70 pS K channel in the medullary thick ascending limb(mTAL).We have now used the patch-clamp technique to study the effect of raising Ca on the70 pS K channel in the mTAL from rats...
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Increasing Ca inhibited the apical 70 pS K channel in the medullary thick ascending limb(mTAL).We have now used the patch-clamp technique to study the effect of raising Ca on the70 pS K channel in the mTAL from rats either on a high K(HK)diet or on a K deficient(KD)*** Ca from 10uM to 0.5 mM;1mM,and 1.5mM in the mTAL from rats on a KD dietinhibited the channel activity by 30%,65% and 90%,*** contrast,raising Ca to1.5 mM had nO significant effect on channel activity in the mTAL from rats on a HK diet and further
Aim and Method:In order to find some evidence of biological neural network behavors in epi-leptogenesis EEG,depth electrographs,primary wet dog shakes(WEDS),T-weighted megnaticresonance image(T-WI),histological se...
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Aim and Method:In order to find some evidence of biological neural network behavors in epi-leptogenesis EEG,depth electrographs,primary wet dog shakes(WEDS),T-weighted megnaticresonance image(T-WI),histological sections,single unit discharges were observed in in vivo ratexperiments after tetanization of the dorsal hippocampus(DHPC).Results:①Obvious T-WI brainabnormalities,electrographic kindling,enlarged lateral ventricle and pathological ventricularchorodea plexus hyperplasia at the early stage of epilepsy,which were characterized by interaction
The modulatory effect of oxytocin(OT)on ATP-activated currents(IATP)was studied infreshly isolated dorsal root ganglion(DRG)neurons of rats using whole cell clamp *** of the neurons examined(50/70,71.4%)extrac...
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The modulatory effect of oxytocin(OT)on ATP-activated currents(IATP)was studied infreshly isolated dorsal root ganglion(DRG)neurons of rats using whole cell clamp *** of the neurons examined(50/70,71.4%)extracellular application of OT(10~10mol/L)suppressed IATP while in the rest(20/70,28.6%)no modulatory effect was *** the ATP concentration-response curve downwards with adecrease of 39.8±4.2%in themaximal current response and with no significant change of Kd *** OT-induced inhibition of
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